- Sox9 Represses alpha-Sarcoglycan Gene Expression in Early Myogenic Differentiation
[作者:Hernandez-Hernandez, JM; Delgado-Olguin, P; Aguillon-Huerta, V; Furlan-Magaril, M; Recillas-Targa, F; Coral-Vazquez, RM,期刊:Journal of Molecular Biology, 页码:1-14 , 文章类型: Article,,卷期:2009年394-1]
- Alpha sarcoglycan (alpha-SG) is highly expressed in differentiated striated muscle, and its disruption causes limb-girdle muscular dystrophy. Accordingly, the myogenic master regulator MyoD finely modulates its expressio...
- Modeling of the Genetic Switch of Bacteriophage TP901-1: A Heteromer of CI and MOR Ensures Robust Bistability
[作者:Nakanishi, H; Pedersen, M; Alsing, AK; Sneppen, K,期刊:Journal of Molecular Biology, 页码:15-28 , 文章类型: Article,,卷期:2009年394-1]
- The lytic-lysogenic switch of the temperate lactococcal phage TP901-1 is fundamentally different from that of phage lambda. In phage TP901-1, the lytic promoter P-L is repressed by CI, whereas repression of the lysogenic...
- Regulated Expression of the alpha Isoform of the Human Thromboxane A(2) Receptor during Megakaryocyte Differentiation: A Coordinated Role for WT1, Egr1, and Sp1
[作者:Gannon, AM; Turner, EC; Reid, HM; Kinsella, BT,期刊:Journal of Molecular Biology, 页码:29-45 , 文章类型: Article,,卷期:2009年394-1]
- Thromboxane plays an essential role in hemostasis, regulating platelet aggregation and vessel tone. In humans, it signals through the TP alpha and TP beta isoforms that are transcriptionally regulated by distinct promote...
- Structural Evaluation of Potent NKT Cell Agonists: Implications for Design of Novel Stimulatory Ligands
[作者:Schiefner, A; Fujio, M; Wu, D; Wong, CH; Wilson, IA,期刊:Journal of Molecular Biology, 页码:71-82 , 文章类型: Article,,卷期:2009年394-1]
- Natural killer T (N-KT) cells are a subset of T cells that are activated by CD1d-glycolipid complexes through a semi-invariant alpha beta T cell receptor (NKT TCR). Upon activation, NKT cells secrete regulatory cytokines...
- Methionine Sulfoxide Reductase B Displays a High Level of Flexibility
[作者:Ranaivoson, FM; Neiers, F; Kauffmann, B; Boschi-Muller, S; Branlant, G; Favier, F,期刊:Journal of Molecular Biology, 页码:83-93 , 文章类型: Article,,卷期:2009年394-1]
- Methionine sulfoxide reductases (Msrs) are enzymes that catalyze the reduction of methionine sulfoxide back to methionine. In vivo, Msrs are essential in the protection of cells against oxidative damage to proteins and i...
- Molecular Insights into the Interaction between alpha-Synuclein and Docosahexaenoic Acid
[作者:De Franceschi, G; Frare, E; Bubacco, L; Mammi, S; Fontana, A; de Laureto, PP,期刊:Journal of Molecular Biology, 页码:94-107 , 文章类型: Article,,卷期:2009年394-1]
- alpha-Synuclein (alpha-syn) is a 140-residue protein of unknown function, involved in several neurodegenerative disorders, such as Parkinson's disease. Recently, the possible interaction between alpha-syn and polyunsatur...
- Prion Fibrils of Ure2p Assembled under Physiological Conditions Contain Highly Ordered, Natively Folded Modules
[作者:Loquet, A; Bousset, L; Gardiennet, C; Sourigues, Y; Wasmer, C; Habenstein, B; Schutz, A; Meier, BH; Melki, R; Bockmann, A,期刊:Journal of Molecular Biology, 页码:108-118 , 文章类型: Article,,卷期:2009年394-1]
- The difference between the prion and the non-prion form of a protein is given solely by its three-dimensional structure, according to the prion hypothesis. It has been shown that solid-state NMR can unravel the atomic-re...
- The Molecular Organization of the Fungal Prion HET-s in Its Amyloid Form
[作者:Wasmer, C; Schutz, A; Loquet, A; Buhtz, C; Greenwald, J; Riek, R; Bockmann, A; Meier, BH,期刊:Journal of Molecular Biology, 页码:119-127 , 文章类型: Article,,卷期:2009年394-1]
- The prion hypothesis states that it is solely the three-dimensional structure of the polypeptide chain that distinguishes the prion and nonprion forms of the protein. For HET-s, the atomic-resolution structure of the iso...
- PilM/N/O/P Proteins Form an Inner Membrane Complex That Affects the Stability of the Pseudomonas aeruginosa Type IV Pilus Secretin
[作者:Ayers, M; Sampaleanu, LM; Tammam, S; Koo, J; Harvey, H; Howell, PL; Burrows, LL,期刊:Journal of Molecular Biology, 页码:128-142 , 文章类型: Article,,卷期:2009年394-1]
- The highly conserved pil/M/N/O/P/Q gene cluster is among the core set of genes required for cell surface expression of type IV pili and associated twitching motility. With the exception of the outer membrane secretin, a ...
- Periplasmic Domains of Pseudomonas aeruginosa PilN and PilO Form a Stable Heterodimeric Complex
[作者:Sampaleanu, LM; Bonanno, JB; Ayers, M; Koo, J; Tammam, S; Burley, SK; Almo, SC; Burrows, LL; Howell, PL,期刊:Journal of Molecular Biology, 页码:143-159 , 文章类型: Article,,卷期:2009年394-1]
- Type IV pili (TV) are bacterial virulence factors responsible for attachment to surfaces and for twitching motility, a motion that involves a succession of pilus extension and retraction cycles. In the opportunistic path...
- Zipping and Unzipping of Adenylate Kinase: Atomistic Insights into the Ensemble of Open <-> Closed Transitions
[作者:Beckstein, O; Denning, EJ; Perilla, JR; Woolf, TB,期刊:Journal of Molecular Biology, 页码:160-176 , 文章类型: Article,,卷期:2009年394-1]
- Adenylate kinase (AdK), a phosphotransferase enzyme, plays an important role in cellular energy homeostasis. It undergoes a large conformational change between an open and a closed state, even in the absence of substrate...
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