- Structural Insights into Yeast DNA Polymerase delta by Small Angle X-ray Scattering
[作者:Jain, R; Hammel, M; Johnson, RE; Prakash, L; Prakash, S; Aggarwal, AK,期刊:Journal of Molecular Biology, 页码:377-382 , 文章类型: Article,,卷期:2009年394-3]
- DNA polymerase delta (Pol delta) is a multisubunit polymerase that plays an indispensable role in replication from yeast to humans. Pol delta from Saccharomyces cerevisiae is composed of three subunits: Pol3, Pol31, and ...
- Single-Molecule Force Spectroscopy Measures Structural Changes Induced by Light Activation and Transducer Binding in Sensory Rhodopsin II
[作者:Oberbarnscheidt, L; Janissen, R; Martell, S; Engelhard, M; Oesterhelt, F,期刊:Journal of Molecular Biology, 页码:383-390 , 文章类型: Article,,卷期:2009年394-3]
- Microbial rhodopsins are a family of seven-helical transmembrane proteins containing retinal as chromophore. Sensory rhodopsin II (SRII) triggers two very different responses upon light excitation, depending on the prese...
- Solution Structure of RCL, a Novel 2 '-Deoxyribonucleoside 5 '-Monophosphate N-glycosidase
[作者:Doddapaneni, K; Mahler, B; Pavlovicz, R; Haushalter, A; Yuan, CH; Wu, ZR,期刊:Journal of Molecular Biology, 页码:423-434 , 文章类型: Article,,卷期:2009年394-3]
- RCL is an enzyme that catalyzes the N-glycosidic bond cleavage of purine 2'-deoxyribonucleoside 5'-monophosphates, a novel enzymatic reaction reported only recently. In this work, we determined the solution structure by ...
- Structural Characterization of the Mammalian Deoxynucleotide N-Hydrolase Rcl and Its Stabilizing Interactions with Two Inhibitors
[作者:Yang, YS; Padilla, A; Zhang, C; Labesse, G; Kaminski, PA,期刊:Journal of Molecular Biology, 页码:435-447 , 文章类型: Article,,卷期:2009年394-3]
- The gene Rcl encodes a deoxynucleoside 5'-monophosphate N-glycosidase that catalyzes the hydrolysis of the N-glycosidic bond of the nucleotide to give deoxyribose 5-phosphate and a nucleobase, preferentially a purine. Th...
- Identification of a Function-Specific Mutation of Clathrin Heavy Chain (CHC) Required for p53 Transactivation
[作者:Ohata, H; Ota, N; Shirouzu, M; Yokoyama, S; Yokota, J; Taya, Y; Enari, M,期刊:Journal of Molecular Biology, 页码:460-471 , 文章类型: Article,,卷期:2009年394-3]
- The p53 pathway is activated in response to various cellular stresses to protect cells from malignant transformation. We have previously shown that clathrin heavy chain (CHC), which is a cytosolic protein regulating endo...
- The On-Off Switch in Regulated Myosins: Different Triggers but Related Mechanisms
[作者:Himmel, DM; Mui, S; O'Neall-Hennessey, E; Szent-Gyorgyi, AG; Cohen, C,期刊:Journal of Molecular Biology, 页码:496-505 , 文章类型: Article,,卷期:2009年394-3]
- In regulated myosin, motor and enzymatic activities are toggled between the on-state and off-state by a switch located on its lever arm domain, here called the regulatory domain (RD). This region consists of a long alpha...
- Coronavirus N Protein N-Terminal Domain (NTD) Specifically Binds the Transcriptional Regulatory Sequence (TRS) and Melts TRS-cTRS RNA Duplexes
[作者:Grossoehme, NE; Li, LC; Keane, SC; Liu, PH; Dann, CE; Leibowitz, JL; Giedroc, DP,期刊:Journal of Molecular Biology, 页码:544-557 , 文章类型: Article,,卷期:2009年394-3]
- All coronaviruses (CoVs), including the causative agent of severe acute respiratory syndrome (SARS), encode a nucleocapsid (N) protein that harbors two independent RNA binding domains of known structure, but poorly chara...
- Binding of Rabies Virus Polymerase Cofactor to Recombinant Circular Nucleoprotein-RNA Complexes
[作者:Ribeiro, ED; Leyrat, C; Gerard, FCA; Albertini, AAV; Falk, C; Ruigrok, RWH; Jamin, M,期刊:Journal of Molecular Biology, 页码:558-575 , 文章类型: Article,,卷期:2009年394-3]
- In rabies virus, the attachment of the L polymerase (L) to the viral nucleocapsids (NCs)-a nucleoprotein (N)-RNA complex that serves as template for RNA transcription and replication-is mediated by the polymerase cofacto...
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