- Genetic variants in major histocompatibility complex-linked genes associate with pediatric liver transplant rejection
[作者：Sindhi, R; Higgs, BW; Weeks, DE; Ashokkumar, C; Jaffe, R; Kim, C; Wilson, P; Chien, N; Glessner, J; Talukdar, A; Mazariegos, G; Barmada, MM; Frackleton, E; Petro, N; Eckert, A; Hakonarson, H; Ferrell, R,期刊：Gastroenterology, 页码：830-839 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: Limited access to large samples precludes genome-wide association studies of rare but complex traits. To localize candidate genes with family-based genome-wide association, a novel exploratory analysis...
- Acute liver cell damage in patients with anorexia nervosa: A possible role of starvation-induced hepatocyte autophagy
[作者：Rautou, PE; Cazals-Hatem, D; Moreau, R; Francoz, C; Feldmann, G; Lebrec, D; Ogier-Denis, E; Bedossa, P; Valla, D; Durand, F,期刊：Gastroenterology, 页码：840-848 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: Acute liver insufficiency is a rare complication of anorexia nervosa. The mechanisms for this complication are unclear. The aim of this study was to describe patient characteristics and clarify the mec...
- Intestinal deletion of Pofut1 in the mouse inactivates Notch signaling and causes enterocolitis
[作者：Guilmeau, S; Flandez, M; Bancroft, L; Sellers, RS; Tear, B; Stanley, P; Augenlicht, LH,期刊：Gastroenterology, 页码：849-860 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: Notch downstream targets are fundamental to intestinal cell lineage commitment and are suggested as therapeutic targets for colon cancer cells. However, the role of endogenous Notch signaling through r...
- A2B adenosine receptor gene deletion attenuates murine colitis
[作者：Kolachala, VL; Vijay-Kumar, M; Dalmasso, G; Yang, D; Linden, J; Wang, LX; Gewirtz, A; Ravid, K; Merlin, D; Sitaraman, SV,期刊：Gastroenterology, 页码：861-870 , 文章类型： Article，,卷期：2008年135-3]
- Background & Significance : The A(2B) adenosine receptor (A(2B)AR) is the predominant adenosine receptor expressed in the colonic epithelia. We have previously shown that A(2B)AR mRNA and protein levels are up-regulated ...
- Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms
[作者：Cenac, N; Altier, C; Chapman, K; Liedtke, W; Zampon, G; Vergnolle, N,期刊：Gastroenterology, 页码：937-946 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: The transient receptor potential vanilloid-4 (TRPV4) is an osmosensitive channel that responds to mechanical stimulation. We hypothesized that TRPV4 could be important in visceral nociception and in th...
- Myeloid-derived suppressor cells in inflammatory bowel disease: A new immunoregulatory pathway
[作者：Haile, LA; Von Wasielewski, R; Gamrekelashvili, J; Kruger, C; Bachmann, O; Westendorf, AM; Buer, J; Liblau, R; Manns, MP; Korangy, F; Greten, TF,期刊：Gastroenterology, 页码：871-881 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) have been shown to cause T-cell tolerance in tumor-bearing mice; however, little is known about the role of MDSCs in chronic inflammation. Here,...
- Role of the protein C pathway in the extraintestinal thrombosis associated with murine colitis
[作者：Yoshida, H; Russell, J; Stokes, KY; Yilmaz, CE; Esmon, CT; Granger, DN,期刊：Gastroenterology, 页码：882-888 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: Chronic inflammatory bowel diseases (IBD) are associated with an increased risk for thromboembolism. Although thrombosis is known to contribute to the morbidity and mortality of patients with IBD, the ...
- Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers
[作者：Endo, Y; Marusawa, H; Kou, T; Nakase, H; Fujii, S; Fujimori, T; Kinoshita, K; Honjo, T; Chiba, T,期刊：Gastroenterology, 页码：889-898 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: Activation-induced cytidine deaminase (AID) was originally identified as an inducer of somatic hypermutations in the immunoglobulin gene. We recently revealed that ectopic AID expression serves as a li...
- B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival
[作者：Matos, P; Oliveira, C; Velho, S; Goncalves, V; Da Costa, LT; Moyer, MP; Seruca, R; Jordan, P,期刊：Gastroenterology, 页码：899-906 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: In colorectal tumors, activating BRAF mutations occur alternative to KRAS oncogenic mutations, but in cell culture possess a much lower transforming capacity. Rac1b, a hyperactive Rac1 spliced variant,...
- Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth
[作者：Fujiki, K; Duerr, EM; Kikuchi, H; Ng, A; Xavier, RJ; Mizukami, Y; Imamura, T; Kulke, MH; Chung, DC,期刊：Gastroenterology, 页码：907-916 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aim: The molecular alterations that underlie carcinoid tumor pathogenesis remain poorly defined. The homeobox gene HOXC6 was highly upregulated in human gastrointestinal carcinoid tumors, and we sought to de...
- Ovalbumin-protein sigma 1 M-cell targeting facilitates oral tolerance with reduction of antigen-specific CD4(+) T cells
[作者：Suzuki, H; Sekine, S; Kataoka, K; Pascual, DW; Maddaloni, M; Kobayashi, R; Fujihashi, K; Kozono, H; McGhee, JR; Fujihashi, K,期刊：Gastroenterology, 页码：917-925 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: The follicle-associated epithelium (FAE) plays key roles in antigen uptake and subsequent induction of mucosal immunity. In this study, we examined whether M-cell targeting using a protein antigen (Ag)...
- Proinflammatory role of leukocyte-derived Egr-1 in the development of murine postoperative ileus
[作者：Schmidt, J; Stoffels, B; Moore, BA; Chanthaphavong, RS; Mazie, AR; Buchholz, BM; Bauer, AJ,期刊：Gastroenterology, 页码：926-936 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: Early growth response gene-1 (Egr-1) is an important inflammatory transcription factor. We hypothesize that leukocyte-derived Egr-1 plays a key inflammatory role in causing postoperative ileus. Methods...
- Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[F-18]fluoro-D-glucose and positron emission tomography
[作者：Brewer, S; McPherson, M; Fujiwara, D; Turovskaya, O; Ziring, D; Chen, L; Takedatsu, H; Targan, SR; Wei, B; Braun, J,期刊：Gastroenterology, 页码：744-755 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: 2-Deoxy-2-[F-18]fluoro-D-glucose (FDG) uptake by positron emission tomography (PET), a measure of glucose transporter activity, has been used to detect mucosal inflammation. However, there is limited u...
- Infectious gastroenteritis and risk of developing inflammatory bowel disease
[作者：Porter, CK; Tribble, DR; Aliaga, PA; Halvorson, HA; Riddle, MS,期刊：Gastroenterology, 页码：781-786 , 文章类型： Article，,卷期：2008年135-3]
- Background & Aims: Infectious gastroenteritis (IGE) is known to exacerbate previously diagnosed inflammatory bowel disease (IBD). However, limited data are available describing a causal link between IGE and incident IBD....
- Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: A Phase I study
[作者：Malfertheiner, P; Schultze, V; Rosenkranz, B; Kaufmann, SHE; Ulrichs, T; Novicki, D; Norelli, F; Contorni, M; Peppoloni, S; Berti, D; Tornese, D; Ganju, J; Palla, E; Rappuoli, R; Scharschmidt, BF; Del Giudice, G,期刊：Gastroenterology, 页码：787-795 , 文章类型： Article，,卷期：2008年135-3]
- Introduction: Helicobacter pylori infection is among the most common human infections and the major risk factor for peptic disease and gastric cancer. Immunization with vaccines containing the H pylori vacuolating cytoto...
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