- A Transient Breach in the Epithelial Barrier Leads to Regulatory T-Cell Generation and Resistance to Experimental Colitis
[作者：Boirivant, M; Amendola, A; Butera, A; Sanchez, M; Xu, LL; Marinaro, M; Kitani, A; Di Giacinto, C; Strober, W; Fuss, IJ,期刊：Gastroenterology, 页码：1612-1623 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: Previous studies have indicated that a defective epithelial barrier leads to inflammation of the underlying lamina propria. Nevertheless, it is likely that physiologic breaks in the barrier must occur ...
- MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2 alpha
[作者：Wu, F; Zikusoka, M; Trindade, A; Dassopoulos, T; Harris, ML; Bayless, TM; Brant, SR; Chakravarti, S; Kwon, JH,期刊：Gastroenterology, 页码：1624-1635 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: Chronic inflammatory bowel diseases such as ulcerative colitis (UC) are associated with differential expression of genes involved in inflammation and tissue remodeling. MicroRNAs (miRNAs), which direct...
- Circadian Clock-Controlled Intestinal Expression of the Multidrug-Resistance Gene mdr1a in Mice
[作者：Murakami, Y; Higashi, Y; Matsunaga, N; Koyanagi, S; Ohdo, S,期刊：Gastroenterology, 页码：1636-1644 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: P-glycoprotein, the product of the multidrug resistance (mdr) gene, function as a xenobiotic transporter contributing to the intestinal barrier. Although intestinal expression of the mdr1a gene and its...
- Effects of Adalimumab Therapy on Incidence of Hospitalization and Surgery in Crohn's Disease: Results From the CHARM Study
[作者：Feagan, BG; Panaccione, R; Sandborn, WJ; D'Haens, GR; Schreiber, S; Rutgeerts, PJ; Loftus, EV; Lomax, KG; Yu, AP; Wu, EQ; Chao, JD; Mulani, P,期刊：Gastroenterology, 页码：1493-1499 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: We determined the effects of adalimumab maintenance treatment on the risks of hospitalization and surgery in Crohn's disease (CD). Methods: A total of 778 patients with CD were randomized to placebo, a...
- Down-regulated in Adenoma Cl/HCO3 Exchanger Couples With Na/H Exchanger 3 for NaCl Absorption in Murine Small Intestine
[作者：Walker, NM; Simpson, JE; Yen, PF; Gill, RK; Rigsby, EV; Brazill, JM; Dudeja, PK; Schweinfest, CW; Clarke, LL,期刊：Gastroenterology, 页码：1645-1653 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: Electroneutral NaCl absorption across small intestine contributes importantly to systemic fluid balance. Disturbances in this process occur in both obstructive and diarrheal. diseases, eg, cystic fibro...
- Meta-Analysis of the Placebo Rates of Clinical Relapse and Severe Endoscopic Recurrence in Postoperative Crohn's Disease
[作者：Renna, S; Camma, C; Modesto, I; Cabibbo, G; Scimega, D; Civitavecchia, G; Mocciaro, F; Orlando, A; Enea, M; Cottone, M,期刊：Gastroenterology, 页码：1500-1509 , 文章类型： Article，,卷期：2008年135-5]
- Backgrounds & Aims: The benefit of therapy for prevention of postoperative recurrence of Crohn's disease (CD) is limited. Clinical relapse and severe endoscopic recurrence are the main outcomes in the evaluation of trial...
- Intestinal Differentiation in Zebrafish Requires Cdx1b, a Functional Equivalent of Mammalian Cdx2
[作者：Flores, MVC; Hall, CJ; Davidson, AJ; Singh, PP; Mahagaonkar, AA; Zon, LI; Crosier, KE; Crosier, PS,期刊：Gastroenterology, 页码：1665-1675 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: The ParaHox transcription factor Cdx2 is an essential determinant of intestinal phenotype in mammals throughout development, influencing gut function, homeostasis, and epithelial barrier integrity. Cdx...
- Oral Budesonide for Maintenance Treatment of Collagenous Colitis: A Randomized, Double-Blind, Placebo-Controlled Trial
[作者：Miehlke, S; Madisch, A; Bethke, B; Morgner, A; Kuhlisch, E; Henker, C; Vogel, G; Andersen, M; Meier, E; Baretton, G; Stolte, M,期刊：Gastroenterology, 页码：1510-1516 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: Oral budesonide effectively induces clinical remission in patients with collagenous colitis, a debilitating illness characterized by chronic watery/loose diarrhea, but there is a high rate of relapse a...
- GATA4 Is Essential for Jejunal Function in Mice
[作者：Battle, MA; Bondow, BJ; Iverson, MA; Adams, SJ; Jandacek, RJ; Tso, P; Duncan, SA,期刊：Gastroenterology, 页码：1676-1686 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: Although the zinc-finger transcription factor GATA4 has been implicated in regulating jejunal gene expression, the contribution of GATA4 in controlling jejunal physiology has not been addressed. Method...
- Lower Gastrointestinal Events in a Double-Blind Trial of the Cyclo-Oxygenase-2 Selective Inhibitor Etoricoxib and the Traditional Nonsteroidal Anti-Inflammatory Drug Diclofenac
[作者：Laine, L; Curtis, SP; Langman, M; Jensen, DM; Cryer, B; Kaur, A; Cannon, CP,期刊：Gastroenterology, 页码：1517-1525 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: Nonsteroidal anti-inflammatory drugs (NSAIDs) cause lower gastrointestinal (GI) clinical events such as bleeding. Cyclo-oxygenase (COX)-2 selective inhibitors decrease upper GI events, but no prospecti...
- MEN1 Missense Mutations Impair Sensitization to Apoptosis Induced by Wild-Type Menin in Endocrine Pancreatic Tumor Cells
[作者：Bazzi, W; Renon, M; Vercherat, C; Hamze, Z; Lacheretz-Bernigaud, A; Wang, H; Blanc, M; Roche, C; Calender, A; Chayvialle, JA; Scoazec, JY; Cordier-Bussat, M,期刊：Gastroenterology, 页码：1698-1709 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: Missense mutations account for 30% of mutations identified in patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome. They raise several issues: the distinction between pathogenic mutati...
- Achalasia: A New Clinically Relevant Classification by High-Resolution Manometry
[作者：Pandolfino, JE; Kwiatek, MA; Nealis, T; Bulsiewicz, W; Post, J; Kahrilas, PJ,期刊：Gastroenterology, 页码：1526-1533 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: Although the diagnosis of achalasia. hinges on demonstrating impaired esophagogastric junction (EGJ) relaxation and aperistalsis, 3 distinct patterns of aperistalsis are discernable with high-resolutio...
- Antiviral Suppression vs Restoration of RIG-I Signaling by Hepatitis C Protease and Polymerase Inhibitors
[作者：Liang, YQ; Ishida, H; Lenz, O; Lin, TI; Nyanguile, O; Simmen, K; Pyles, RB; Bourne, N; Yi, MK; Li, K; Lemon, SM,期刊：Gastroenterology, 页码：1710-1718 , 文章类型： Article，,卷期：2008年135-5]
- Background & Aims: Expression of the nonstructural protein (NS)3/4A protease in cells infected with hepatitis C virus (HCV) results in cleavage of the mitochondrial antiviral-signaling protein (MAVS) and disruption of si...
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