- New drugs in advanced non-small-cell lung cancer: searching for the correct clinical development
[作者:Di Maio, M; Morabito, A; Piccirillo, MC; Daniele, G; Giordano, P; Costanzo, R; Riccardi, MG; Rocco, G; Normanno, N; Perrone, F,期刊:Expert opinion on investigational drugs, 页码:1503-1514 , 文章类型: Review,,卷期:2010年19-12]
- Importance of the field: Non-small-cell lung cancer (NSCLC) is one of the most active fields of research in oncology, with many drugs under clinical development. Most of these drugs offer novel mechanisms of action compa...
- Biological versatility of crotamine - a cationic peptide from the venom of a South American rattlesnake
[作者:Kerkis, I; Silva, FD; Pereira, A; Kerkis, A; Radis-Baptista, G,期刊:Expert opinion on investigational drugs, 页码:1515-1525 , 文章类型: Review,,卷期:2010年19-12]
- Importance of the field: Molecules isolated from animals, insects, plants or microorganisms can provide prototypes for design of biopharmaceutical products. Some venom toxins and their derivatives are used in medicine, w...
- Na+/H+ exchanger-1: a link with atherogenesis?
[作者:Sarigianni, M; Tsapas, A; Mikhailidis, DP; Kaloyianni, M; Koliakos, G; Fliegel, L; Paletas, K,期刊:Expert opinion on investigational drugs, 页码:1545-1556 , 文章类型: Review,,卷期:2010年19-12]
- Importance of the field: The sodium/hydrogen exchanger-1 (NHE-1/SLC9A1) is a ubiquitous plasma membrane protein whose main role is maintenance of intracellular pH and volume. NHE-1 plays a role in atherogenesis; however,...
- Inhibiting PAR-1 in the prevention and treatment of atherothrombotic events
[作者:Tomasello, SD; Angiolillo, DJ; Goto, S,期刊:Expert opinion on investigational drugs, 页码:1557-1567 , 文章类型: Review,,卷期:2010年19-12]
- Importance of the field: Aspirin, an irreversible inhibitor of thromboxane A(2) production, in combination with clopidogrel, an inhibitor of PY12 ADP platelet receptors, represents the current standard-of-care of antipla...
- Delayed release phosphatidylcholine as new therapeutic drug for ulcerative colitis - a review of three clinical trials
[作者:Stremmel, W; Hanemann, A; Braun, A; Stoffels, S; Karner, M; Fazeli, S; Ehehalt, R,期刊:Expert opinion on investigational drugs, 页码:1623-1630 , 文章类型: Article,,卷期:2010年19-12]
- Importance of the field: As the pathogenesis of ulcerative colitis (UC) is unknown, a causative therapy is lacking. Therefore, some UC patients suffer from disease activity despite symptomatic anti-inflammatory treatment...
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