- Metformin and cancer: licence to heal?
[作者:Papanas, N; Maltezos, E; Mikhailidis, DP,期刊:Expert opinion on investigational drugs, 页码:913-917 , 文章类型: Editorial Material,,卷期:2010年19-8]
- Type 2 diabetes mellitus is associated with increased risk of malignancy (mainly cancer of the pancreas, breast, colon, endometrium and bladder). In addition, there is evidence that antidiabetic medication may itself aff...
- New inhibitors of the mammalian target of rapamycin signaling pathway for cancer
[作者:Albert, S; Serova, M; Dreyer, C; Sablin, MP; Faivre, S; Raymond, E,期刊:Expert opinion on investigational drugs, 页码:919-930 , 文章类型: Review,,卷期:2010年19-8]
- Importance of the field: Contrasting with the broad activation of the PI3K/AKT/mammalian target of rapamycin (mTOR) survival pathway in most cancer, activity of rapalogues appears to be restricted to a few tumor types. A...
- Preclinical evidence of new opioid modulators for the treatment of addiction
[作者:Rodriguez-Arias, M; Aguilar, MA; Manzanedo, C; Minarro, J,期刊:Expert opinion on investigational drugs, 页码:977-994 , 文章类型: Review,,卷期:2010年19-8]
- Importance of the field: Addiction to opiates is one of the most severe forms of substance dependence, and despite a variety of pharmacological approaches to treat it, relapse is observed in a high percentage of subjects...
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