- Determinants for Activation of the Atypical AGC Kinase Greatwall during M Phase Entry
[作者:Blake-Hodek, KA; Williams, BC; Zhao, Y; Castilho, PV; Chen, W; Mao, YX; Yamamoto, TM; Goldberg, ML,期刊:Molecular and Cellular Biology, 页码:1337-1353 , 文章类型: Article,,卷期:2012年32-8]
- The atypical AGC kinase Greatwall (Gwl) mediates a pathway that prevents the precocious removal of phosphorylations added to target proteins by M phase-promoting factor (MPF); Gwl is thus essential for M phase entry and ...
- Unmodified Histone H3K4 and DNA-Dependent Protein Kinase Recruit Autoimmune Regulator to Target Genes
[作者:Zumer, K; Low, AK; Jiang, HM; Saksela, K; Peterlin, BM,期刊:Molecular and Cellular Biology, 页码:1354-1362 , 文章类型: Article,,卷期:2012年32-8]
- Autoimmune regulator (AIRE) directs the expression of otherwise tissue-restricted antigens (TRAs) in medullary thymic epithelial cells, allowing their presentation to developing T cells, which leads to central tolerance....
- Rcf1 and Rcf2, Members of the Hypoxia-Induced Gene 1 Protein Family, Are Critical Components of the Mitochondrial Cytochrome bc(1)-Cytochrome c Oxidase Supercomplex
[作者:Strogolova, V; Furness, A; Robb-McGrath, M; Garlich, J; Stuart, RA,期刊:Molecular and Cellular Biology, 页码:1363-1373 , 文章类型: Article,,卷期:2012年32-8]
- We report that Rcf1 (formerly Aim31), a member of the conserved hypoxia-induced gene 1 (Hig1) protein family, represents a novel component of the yeast cytochrome bc(1)-cytochrome c oxidase (COX) supercomplex. Rcf1 (resp...
- The RalB Small GTPase Mediates Formation of Invadopodia through a GTPase-Activating Protein-Independent Function of the RalBP1/RLIP76 Effector
[作者:Neel, NF; Rossman, KL; Martin, TD; Hayes, TK; Yeh, JJ; Der, CJ,期刊:Molecular and Cellular Biology, 页码:1374-1386 , 文章类型: Article,,卷期:2012年32-8]
- Our recent studies implicated key and distinct roles for the highly related RalA and RalB small GTPases (82% sequence identity) in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and invasive and metastatic growth,...
- A Role for Sphingomyelin-Rich Lipid Domains in the Accumulation of Phosphatidylinositol-4,5-Bisphosphate to the Cleavage Furrow during Cytokinesis
[作者:Abe, M; Makino, A; Hullin-Matsuda, F; Kamijo, K; Ohno-Iwashita, Y; Hanada, K; Mizuno, H; Miyawaki, A; Kobayashi, T,期刊:Molecular and Cellular Biology, 页码:1396-1407 , 文章类型: Article,,卷期:2012年32-8]
- Cytokinesis is a crucial step in the creation of two daughter cells by the formation and ingression of the cleavage furrow. Here, we show that sphingomyelin (SM), one of the major sphingolipids in mammalian cells, is req...
- Activation of Myeloid Cell-Specific Adhesion Class G Protein-Coupled Receptor EMR2 via Ligation-Induced Translocation and Interaction of Receptor Subunits in Lipid Raft Microdomains
[作者:Huang, YS; Chiang, NY; Hu, CH; Hsiao, CC; Cheng, KF; Tsai, WP; Yona, S; Stacey, M; Gordon, S; Chang, GW; Lin, HH,期刊:Molecular and Cellular Biology, 页码:1408-1420 , 文章类型: Article,,卷期:2012年32-8]
- The adhesion class G protein-coupled receptors (adhesion-GPCRs) play important roles in diverse biological processes ranging from immunoregulation to tissue polarity, angiogenesis, and brain development. These receptors ...
- Twist-1 Induces Ezh2 Recruitment Regulating Histone Methylation along the Ink4A/Arf Locus in Mesenchymal Stem Cells
[作者:Cakouros, D; Isenmann, S; Cooper, L; Zannettino, A; Anderson, P; Glackin, C; Gronthos, S,期刊:Molecular and Cellular Biology, 页码:1433-1441 , 文章类型: Article,,卷期:2012年32-8]
- The main impairment to tissue maintenance during aging is the reduced capacity for stem cell self-renewal over time due to senescence, the irreversible block in proliferation. We have previously described that the basic ...
- MacroH2A1 Regulates the Balance between Self-Renewal and Differentiation Commitment in Embryonic and Adult Stem Cells
[作者:Creppe, C; Janich, P; Cantarino, N; Noguera, M; Valero, V; Musulen, E; Douet, J; Posavec, M; Martin-Caballero, J; Sumoy, L; Di Croce, L; Benitah, SA; Buschbeck, M,期刊:Molecular and Cellular Biology, 页码:1442-1452 , 文章类型: Article,,卷期:2012年32-8]
- One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight into the poorly recogni...
- Genome-Wide Determination of a Broad ESRP-Regulated Posttranscriptional Network by High-Throughput Sequencing
[作者:Dittmar, KA; Jiang, P; Park, JW; Amirikian, K; Wan, J; Shen, SH; Xing, Y; Carstens, RP,期刊:Molecular and Cellular Biology, 页码:1468-1482 , 文章类型: Article,,卷期:2012年32-8]
- Tissue-specific alternative splicing is achieved through the coordinated assembly of RNA binding proteins at specific sites to enhance or silence splicing at nearby splice sites. We used high-throughput sequencing (RNA-S...
- Mediator Subunits MED1 and MED24 Cooperatively Contribute to Pubertal Mammary Gland Development and Growth of Breast Carcinoma Cells
[作者:Hasegawa, N; Sumitomo, A; Fujita, A; Aritome, N; Mizuta, S; Matsui, K; Ishino, R; Inoue, K; Urahama, N; Nose, J; Mukohara, T; Kamoshida, S; Roeder, RG; Ito, M,期刊:Molecular and Cellular Biology, 页码:1483-1495 , 文章类型: Article,,卷期:2012年32-8]
- The Mediator subunit MED1 is essential for mammary gland development and lactation, whose contribution through direct interaction with estrogen receptors (ERs) is restricted to involvement in pubertal mammary gland devel...
- In Vitro and In Vivo Antiangiogenic Properties of the Serpin Protease Nexin-1
[作者:Selbonne, S; Azibani, F; Iatmanen, S; Boulaftali, Y; Richard, B; Jandrot-Perrus, M; Bouton, MC; Arocasa, V,期刊:Molecular and Cellular Biology, 页码:1496-1505 , 文章类型: Article,,卷期:2012年32-8]
- The serpin protease nexin-1 (PN-1) is expressed by vascular cells and secreted by platelets upon activation, and it is known to interact with several modulators of angiogenesis, such as proteases, matrix proteins, and gl...
- PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function
[作者:Ma, JL; Cai, H; Wu, TD; Sobhian, B; Huo, YY; Alcivar, A; Mehta, M; Cheung, KL; Ganesan, S; Kong, ANT; Zhang, DD; Xia, B,期刊:Molecular and Cellular Biology, 页码:1506-1517 , 文章类型: Article,,卷期:2012年32-8]
- PALB2/FANCN is mutated in breast and pancreatic cancers and Fanconi anemia (FA). It controls the intranuclear localization, stability, and DNA repair function of BRCA2 and links BRCA1 and BRCA2 in DNA homologous recombin...
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