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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Factor D Inhibitors for the Treatment of AMD Patent Highlight [作者：ABDELMAGID AHMED F,期刊：ACS Medicinal Chemistry Letters, 页码：781-782 , 文章类型： Editorial Material，,卷期：2012年3-10] Combatting Drug-Resistant Bacteria with Gyrase and Topoisomerase IV Inhibitors Patent Highlight [作者：ABDELMAGID AHMED F,期刊：ACS Medicinal Chemistry Letters, 页码：783-784 , 文章类型： Editorial Material，,卷期：2012年3-10] Novel Use of Leflunomide and Malononitrilamides Patent Highlight [作者：ROSSE GERARD,期刊：ACS Medicinal Chemistry Letters, 页码：785-785 , 文章类型： Editorial Material，,卷期：2012年3-10] Use of Bupropion in the Treatment of Sexual Dysfunction Patent Highlight [作者：ROSSE GERARD,期刊：ACS Medicinal Chemistry Letters, 页码：786-786 , 文章类型： Editorial Material，,卷期：2012年3-10] Imidazotriazinone Compounds Patent Highlight [作者：ROTELLA DAVID P,期刊：ACS Medicinal Chemistry Letters, 页码：787-787 , 文章类型： Editorial Material，,卷期：2012年3-10] Novel Compounds for the Treatment of Neurodegenerative Diseases Patent Highlight [作者：ROTELLA DAVID P,期刊：ACS Medicinal Chemistry Letters, 页码：788-788 , 文章类型： Editorial Material，,卷期：2012年3-10] Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47 [作者：WEINSTOCK JOSEPH; WU JIAN; CAO PING; KINGSBURY WILLIAM D; MCDERMOTT JEFFREY L; KODRASOV MATTHEW P; MCKELVEY DEVIN M; KUMAR K G SURESH; GOLDENBERG SETH J; MATTERN MICHAEL R; NICHOLSON BENJAMIN,期刊：ACS Medicinal Chemistry Letters, 页码：789-792 , 文章类型： Article，,卷期：2012年3-10] Inhibitors of the cancer-related cysteine isopeptidase human ubiquitin-specific proteases 7 (USP7) and 47 (USP47) are considered to have potential as cancer therapeutics, owing to their ability to stabilize the tumor sup... Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors [作者：YU JIANXIN; LIU HAIYAN; XIA GUANGXIN; LIU LIN; XU ZHENMIN; CHEN QIAN; MA CHEN; SUN XING; XU JIAJUN; LI HUA; LI PING; SHI YUFANG; XIONG BING; LIU XUEJUN; SHEN JINGKANG,期刊：ACS Medicinal Chemistry Letters, 页码：793-798 , 文章类型： Article，,卷期：2012年3-10] On the basis of scaffold hopping, a novel series of 2-alkyl-1-arylsulfonylprolinamides was discovered as 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1) inhibitors. A representative compound 4ek, obtained thr... Syntheses of Siderophore-Drug Conjugates Using a Convergent Thiol-Maleimide System [作者：JUAREZHERNANDEZ RAUL E; MILLER PATRICIA A; MILLER MARVIN J,期刊：ACS Medicinal Chemistry Letters, 页码：799-803 , 文章类型： Article，,卷期：2012年3-10] Three siderophore-drug conjugates (sideromycins) were synthesized by preparation of a maleimide linked derivative of the siderophore desferrioxamine B and reacting the corresponding Ga3+-complex with freshly prepared thi... Structure-Activity Relationships for Side Chain Oxysterol Agonists of the Hedgehog Signaling Pathway [作者：CORMAN AUDREY; DEBERARDINIS ALBERT M; HADDEN M KYLE,期刊：ACS Medicinal Chemistry Letters, 页码：828-833 , 文章类型： Article，,卷期：2012年3-10] Oxysterols (OHCs) are byproducts of cholesterol oxidation that are known to activate the Hedeghog (Hh) signaling pathway. While OHCs that incorporate hydroxyl groups throughout the scaffold are known, those that act as a... Synthesis of [C-11]Am80 via Novel Pd(0)-Mediated Rapid [C-11] Carbonylation Using Arylboronate and [C-11]Carbon Monoxide [作者：TAKASHIMAHIRANO MISATO; ISHII HIDEKI; SUZUKI MASAAKI,期刊：ACS Medicinal Chemistry Letters, 页码：804-807 , 文章类型： Article，,卷期：2012年3-10] C-11-labeled methylbenzoates [C-11]4a-d were synthesized using Pd(0)-mediated rapid cross-coupling reactions employing [C-11] carbon monoxide and arylboronic acid neopentyl glycol esters 3a-d under atmospheric pressure i... Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies [作者：DOCKENDORFF CHRIS; NAGIEC MAREK M; WEIWER MICHEL; BUHRLAGE SARA; TING AMAL; NAG PARTHA P; GERMAIN ANDREW; KIM HANJE; YOUNGSAYE WILLMEN; SCHERER CHRISTINA; BENNION MELISSA; XUE LINLONG; STANTON BENJAMIN Z; LEWIS TIMOTHY A; MACPHERSON LAWRENCE; PALMER MICHELLE; FOLEY MICHAEL A; PEREZ JOSE R; SCHREIBER STUART L,期刊：ACS Medicinal Chemistry Letters, 页码：808-813 , 文章类型： Article，,卷期：2012年3-10] Macrocyclic Hedgehog (Hh) pathway inhibitors have been discovered with improved potency and maximal inhibition relative to the previously reported macrocycle robotnikinin. Analogues were prepared using a modular and effi... Antifungal Spectrum, In Vivo Efficacy, and Structure-Activity Relationship of Ilicicolin H [作者：SINGH SHEO B; LIU WEIGUO; LI XIAOHUA; CHEN TOM; SHAFIEE ALI; CARD DEBORAH; ABRUZZO GEORGE; FLATTERY AMY; GILL CHARLES; THOMPSON JOHN R; ROSENBACH MARK; DREIKORN SARAH; HORNAK VIKTOR; MEINZ MARIA; KURTZ MYRA; KELLY ROSEMARIE; ONISHI JANET C,期刊：ACS Medicinal Chemistry Letters, 页码：814-817 , 文章类型： Article，,卷期：2012年3-10] Ilicicolin H is a polyketide-nonribosomal peptide synthase (NRPS)-natural product isolated from Gliocadium roseum, which exhibits potent and broad spectrum antifungal activity, with sub-mu g/mL MICs against Candida spp.,... The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol [作者：KIM MICHELLE B; OBRIEN TERRENCE E; MOORE JARED T; ANDERSON DAVID E; FOSS MARIE H; WEIBEL DOUGLAS B; AMES JAMES B; SHAW JARED T,期刊：ACS Medicinal Chemistry Letters, 页码：818-822 , 文章类型： Article，,卷期：2012年3-10] The synthesis and antimicrobial activity of heterocyclic analogues of the diterpenoid totarol are described. An advanced synthetic intermediate with a ketone on the A-ring is used to attach fused heterocycles, and a carb... Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate [作者：KEITH JOHN M; APODACA RICH; TICHENOR MARK; XIAO WEI; JONES WILLIAM; PIERCE JOAN; SEIERSTAD MARK; PALMER JAMES; WEBB MICHAEL; KARBARZ MARK; SCOTT BRIAN; WILSON SANDY; LUO LIN; WENNERHOLM MICHELLE; CHANG LEON; BROWN SEAN; RIZZOLIO MICHELE; RYNBERG RAYMOND; CHAPLAN SANDRA; BREITENBUCHER J GUY,期刊：ACS Medicinal Chemistry Letters, 页码：823-827 , 文章类型： Article，,卷期：2012年3-10] A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elev... Discovery of a Novel Chemotype of Tyrosine Kinase Inhibitors by Fragment-Based Docking and Molecular Dynamics [作者：ZHAO HONGTAO; DONG JING; LAFLEUR KARINE; NEVADO CRISTINA; CAFLISCH AMEDEO,期刊：ACS Medicinal Chemistry Letters, 页码：834-838 , 文章类型： Article，,卷期：2012年3-10] We have discovered a novel chemical class of inhibitors of the EphB4 tyrosine kinase by fragment-based high-throughput docking followed by explicit solvent molecular dynamics simulations for assessment of the binding mod...