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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Potassium Channel Modulators as Possible Treatment for Pain Patent Highlight [作者：ABDELMAGID AHMED F,期刊：ACS Medicinal Chemistry Letters, 页码：608-609 , 文章类型： Editorial Material，,卷期：2012年3-8] JAK Kinase Inhibitors as Possible Treatment for Myeloproliferative Disorders and Cancer Patent Highlight [作者：ABDELMAGID AHMED F,期刊：ACS Medicinal Chemistry Letters, 页码：610-611 , 文章类型： Editorial Material，,卷期：2012年3-8] Fatty Acid Synthase Inhibitors as Possible Treatment for Cancer Patent Highlight [作者：ABDELMAGID AHMED F,期刊：ACS Medicinal Chemistry Letters, 页码：612-613 , 文章类型： Editorial Material，,卷期：2012年3-8] Substituted Benzimidazole and Imidazopyridine Compounds Useful as Cyp17 Modulators Patent Highlight [作者：BLASS BENJAMIN,期刊：ACS Medicinal Chemistry Letters, 页码：614-615 , 文章类型： Editorial Material，,卷期：2012年3-8] Fused Heterocyclic Compounds as Ion Channel Modulators Patent Highlight [作者：BLASS BENJAMIN,期刊：ACS Medicinal Chemistry Letters, 页码：616-617 , 文章类型： Editorial Material，,卷期：2012年3-8] Derivatives of Heteroarylsulfonamides, Their Preparation, and Their Application in Human Therapy Patent Highlight [作者：BLASS BENJAMIN,期刊：ACS Medicinal Chemistry Letters, 页码：618-619 , 文章类型： Editorial Material，,卷期：2012年3-8] Binding Model for the Interaction of Anticancer Arylsulfonamides with the p300 Transcription Cofactor [作者：SHI QI; YIN SHAOMAN; KALUZ STEFAN; NI NANTING; DEVI NARRA SAROJINI; MUN JIYOUNG; WANG DANZHU; DAMERA KRISHNA; CHEN WEIXUAN; BURROUGHS SARAH; MOORING SUAZETTE REID; GOODMAN MARK M; VAN MEIR ERWIN G; WANG BINGHE; SNYDER JAMES P,期刊：ACS Medicinal Chemistry Letters, 页码：620-625 , 文章类型： Article，,卷期：2012年3-8] Hypoxia inducible factors (HIFs) are transcription factors that activate expression of multiple gene products and promote tumor adaptation to a hypoxic environment. To become transcriptionally active, HIFs associate with... Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus [作者：TOMASIC TIHOMIR; SINK ROMAN; ZIDAR NACE; FIC ANJA; CONTRERASMARTEL CARLOS; DESSEN ANDREA; PATIN DELPHINE; BLANOT DIDIER; MUELLERPREMRU MANICA; GOBEC STANISLAV; ZEGA ANAMARIJA; KIKELJ DANIJEL; MASIC LUCIJA PETERLIN,期刊：ACS Medicinal Chemistry Letters, 页码：626-630 , 文章类型： Article，,卷期：2012年3-8] MurD and MurE ligases, consecutive enzymes participating in the intracellular steps of bacterial peptidoglycan biosynthesis, are important targets for antibacterial drug discovery. We have designed, synthesized, and eval... Synthesis and Antitumor Activity of Ellagic Acid Peracetate [作者：REN YULIN; WEI MIN; STILL PATRICK C; YUAN SHUNZONG; DENG YOUCAI; CHEN XIAOZHUO; HIMMELDIRK KLAUS; KINGHORN A DOUGLAS; YU JIANHUA,期刊：ACS Medicinal Chemistry Letters, 页码：631-636 , 文章类型： Article，,卷期：2012年3-8] Ellagic acid (1) was synthesized for the first time from methyl gallate through a-pentagalloylglucose (alpha-PGG), and ellagic acid peracetate (3,4,3',4'-tetra-O-acetylellagic acid, 2) was derived from 1 by acetylation. ... Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects [作者：DVORAK CURT A; LIU CHANGLU; SHELTON JONATHAN; KUEI CHESTER; SUTTON STEVEN W; LOVENBERG TIMOTHY W; CARRUTHERS NICHOLAS I,期刊：ACS Medicinal Chemistry Letters, 页码：637-639 , 文章类型： Article，,卷期：2012年3-8] Following the characterization of the lactate receptor (GPR81), a focused screening effort afforded 3-hydroxybenzoic acid 1 as a weak agonist of both GPR81 and GPR109a (niacin receptor). An examination of structurally si... Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers [作者：HARVEY JESSICA H; LONG DARCIE H; ENGLAND PAMELA M; WHISTLER JENNIFER L,期刊：ACS Medicinal Chemistry Letters, 页码：640-644 , 文章类型： Article，,卷期：2012年3-8] Opioid receptors, including the mu- and delta-opioid receptors (MOR and DOR), are important targets for the treatment of pain. Although there is mounting evidence that these receptors form heteromers, the functional role... Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents [作者：ELELIMAT TAMAM; ZHANG XIAOLI; JARJOURA DAVID; MOY FRANKLIN J; ORJALA JIMMY; KINGHORN A DOUGLAS; PEARCE CEDRIC J; OBERLIES NICHOLAS H,期刊：ACS Medicinal Chemistry Letters, 页码：645-649 , 文章类型： Article，,卷期：2012年3-8] A collaborative project has been undertaken to explore filamentous fungi, cyanobacteria, and tropical plants for anticancer drug leads. Through principal component analysis, the chemical space covered by compounds isolat... Monitoring the Distribution of Warfarin in Blood Plasma [作者：ROSENGREN ANNIKA M; KARLSSON BJORN C G; NICHOLLS IAN A,期刊：ACS Medicinal Chemistry Letters, 页码：650-652 , 文章类型： Article，,卷期：2012年3-8] Warfarin is an anticoagulant drug extensively used in the treatment and prevention of thrombotic disorders. Previous studies have shown that warfarin binds extensively to blood plasma proteins and that only a small fract... Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12 [作者：COBOSCORREA AMANDA; STEIN FRANK; SCHULTZ CARSTEN,期刊：ACS Medicinal Chemistry Letters, 页码：653-657 , 文章类型： Article，,卷期：2012年3-8] We describe a prodrug concept in which the target enzyme MMP12 produces its own inhibitor in a two-step activation procedure. By using an MMP12-specific peptide sequence and a known sulfonamide drug integrated in the bac... Brain Penetrant LRRK2 Inhibitor [作者：CHOI HWAN GEUN; ZHANG JINWEI; DENG XIANMING; HATCHER JOHN M; PATRICELLI MATTHEW P; ZHAO ZHENG; ALESSI DARIO R; GRAY NATHANAEL S,期刊：ACS Medicinal Chemistry Letters, 页码：658-662 , 文章类型： Article，,卷期：2012年3-8] Activating mutations in leucine-rich repeat kinase 2 (LARK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target. Here, we report that a 2-anilino-4-methylamino... Antimicrobial Activity of Adenine-Based Inhibitors of NAD(+)-Dependent DNA Ligase [作者：BUURMAN ED T; LAGANAS VALERIE A; LIU CE FENG; MANCHESTER JOHN I,期刊：ACS Medicinal Chemistry Letters, 页码：663-667 , 文章类型： Article，,卷期：2012年3-8] The relationship between enzyme inhibition and antimicrobial potency of adenine-based NAD(+)-dependent DNA ligase (LigA) inhibitors was investigated using a strain of the Gram-negative pathogen Haemophilus influenzae lac...