- Carrier cell-based delivery of replication-competent HSV-1 mutants enhances antitumor effect for ovarian cancer
[作者:Fujiwara, S; Nawa, A; Luo, C; Kamakura, M; Goshima, F; Kondo, C; Kiyono, T; Kikkawa, F; Nishiyama, Y,期刊:Cancer gene therapy, 页码:77-86 , 文章类型: Article,,卷期:2011年18-2]
- Oncolytic viruses capable of tumor-selective replication and cytolysis have shown early promise as cancer therapeutics. We have developed replication-competent attenuated herpes simplex virus type 1 (HSV-1) mutants, name...
- Lentiviral transfer of an inducible transgene expressing a soluble form of Gas1 causes glioma cell arrest, apoptosis and inhibits tumor growth
[作者:Lopez-Ornelas, A; Mejia-Castillo, T; Vergara, P; Segovia, J,期刊:Cancer gene therapy, 页码:87-99 , 文章类型: Article,,卷期:2011年18-2]
Gliomas are the most frequent primary tumors of the central nervous system, and their clinical prognosis remains very poor. Because of the characteristics of gliomas, gene therapy appears as a potentially relevant str...
- Cotargeting of VEGFR-1 and-3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice
[作者:Sallinen, H; Anttila, M; Grohn, O; Koponen, J; Hamalainen, K; Kholova, I; Kosma, VM; Heinonen, S; Alitalo, K; Yla-Herttuala, S,期刊:Cancer gene therapy, 页码:100-109 , 文章类型: Article,,卷期:2011年18-2]
- Despite optimal surgery and chemotherapy, the prognosis of ovarian cancer patients remains poor and new treatments are urgently needed. Solid tumors require the formation of new vessels for growth and metastasis. In the ...
- Gene therapy with interleukin-10 receptor and interleukin-12 induces a protective interferon-gamma-dependent response against B16F10-Nex2 melanoma
[作者:Marchi, LHL; Paschoalin, T; Travassos, LR; Rodrigues, EG,期刊:Cancer gene therapy, 页码:110-122 , 文章类型: Article,,卷期:2011年18-2]
Antitumor immune responses are associated with proinflammatory cytokines, whereas tumor-developing animals generally have increased the production of immunosuppressive cytokines. Here, we show that splenocytes from C5...
- Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer
[作者:Du, J; Liu, J; Smith, BJ; Tsao, MS; Cullen, JJ,期刊:Cancer gene therapy, 页码:135-143 , 文章类型: Article,,卷期:2011年18-2]
- K-ras mutations occur in as high as 95% of patients with pancreatic cancer. K-ras activates Rac1-dependent NADPH oxidase, a key source of superoxide. Superoxide has an important function in pancreatic cancer cell prolife...
- Targeting of tumor radioiodine therapy by expression of the sodium iodide symporter under control of the survivin promoter
[作者:Huang, R; Zhao, Z; Ma, X; Li, S; Gong, R; Kuang, A,期刊:Cancer gene therapy, 页码:144-152 , 文章类型: Article,,卷期:2011年18-2]
- To test the feasibility of using the survivin promoter to induce specific expression of sodium/iodide symporter (NIS) in cancer cell lines and tumors for targeted use of radionuclide therapy, a recombinant adenovirus, Ad...
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