- Hydrolytic cleavage of DNA by urea-bridged macrocyclic polyamines
[作者:Li, J; Zhang, J; Lu, QS; Yue, Y; Huang, Y; Zhang, DW; Lin, HH; Chen, SY; Yu, XQ,期刊:European Journal of Medicinal Chemistry, 页码:5090-5093 , 文章类型: Article,,卷期:2009年44-12]
- Novel bis-cyclen derivative A with urea, mono-cyclen derivative B with urea and amino acid urea C were synthesized as DNA cleavage agents. The structures of these new compounds were identified by MS and H-1 NMR spectrosc...
- Cytotoxicity and effects of 1,10-phenanthroline and 5-amino-1,10-phenanthroline derivatives on some immunocompetent cells
[作者:Wesselinova, D; Kaloyanov, N; Dimitrov, G,期刊:European Journal of Medicinal Chemistry, 页码:5099-5102 , 文章类型: Article,,卷期:2009年44-12]
- The biological activity of previously synthesized compounds [(phen)(3)(H+)(2)(NO3-)(2) (1), Pd(5-NH2-phen)(2)(NO3)(2) (2) and Pd(phen)(2)(NO3)(2)(H2O) (3)] was investigated in vivo. The three compounds did not show any h...
- Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2
[作者:Groszek, G; Nowak-Krol, A; Wdowik, T; Swierczynski, D; Bednarski, M; Otto, M; Walczak, M; Filipek, B,期刊:European Journal of Medicinal Chemistry, 页码:5103-5111 , 文章类型: Article,,卷期:2009年44-12]
- The synthesis of (2RS)-1-(5-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan2-ol and (2RS)-1-(7-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-o1 and its enantiomers, analogs of 1-...
- Synthesis and antibacterial activity of some novel bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and bis-4-thiazolidinone derivatives from terephthalic dihydrazide
[作者:Palekar, VS; Damle, AJ; Shukla, SR,期刊:European Journal of Medicinal Chemistry, 页码:5112-5116 , 文章类型: Article,,卷期:2009年44-12]
- A novel series of 1,4-bis(6-(substituted phenyl)-[1,2,4]-triazolo[3,4-b]-1,3,4-thiadiazoles (5a-b) and 4-bis(substituted phenyl)-4-thiazolidinone derivatives (7a-c) have been synthesized from terephthalic dihydrazide (1)...
- Activity and molecular modeling of a new small molecule active against NNRTI-resistant HIV-1 mutants
[作者:Carta, A; Pricl, S; Piras, S; Fermeglia, M; La Colla, P; Loddo, R,期刊:European Journal of Medicinal Chemistry, 页码:5117-5122 , 文章类型: Article,,卷期:2009年44-12]
- In this preliminary study we report the antiviral screening of triazolo[4,5-g]quinoline derivatives (compounds 1-6). 4,9-Dihydrotriazolo[4,5-g]quinoline-1-oxide (1) stood out as a new, small molecule endowed with a selec...
- 2-Azetidinone derivatives: Design, synthesis, in vitro anti-microbial, cytotoxic activities and DNA cleavage study
[作者:Keri, RS; Hosamani, KM; Shingalapur, RV; Reddy, HRS,期刊:European Journal of Medicinal Chemistry, 页码:5123-5130 , 文章类型: Article,,卷期:2009年44-12]
- A novel series of 3-chloro-4-[4-(2-oxo-2H-chromen-4-ylmethoxy)-phenyl]-1-phenyl-azetidin-2-one derivatives (5a-j) have been synthesized from 4-aryloxymethylcoumarins (la-e) and 4-aryliminomethylphenols (3a-b). The title ...
- Analgesic, anticonvulsant and anti-inflammatory activities of some synthesized benzodiazipine, triazolopyrimidine and bis-imide derivatives
[作者:Said, SA; Amr, AEGE; Sabry, NM; Abdalla, MM,期刊:European Journal of Medicinal Chemistry, 页码:4787-4792 , 文章类型: Article,,卷期:2009年44-12]
- A series of diazipine, pyrimidine, fused triazolopyrimidine and imide derivatives were newly synthesized using 4-phenyl-but-3-en-2-one 1 as a starting material and compounds 2 and 9 are intermediates. Initially the acute...
- Discovery of potential ZAP-70 kinase inhibitors: Pharmacophore design, database screening and docking studies
[作者:Sanam, R; Vadivelan, S; Tajne, S; Narasu, L; Rambabu, G; Jagarlapudi, SARP,期刊:European Journal of Medicinal Chemistry, 页码:4793-4800 , 文章类型: Article,,卷期:2009年44-12]
- The best ZAP-70 inhibitor model consists of four-pharmacophore features, (1) one hydrogen bond acceptor, (2) one hydrogen bond donor (3) one hydrophobic aliphatic and (4) one hydrophobic aromatic features. This model was...
- Biological activity studies on metal complexes of novel tridentate Schiff base ligand. Spectroscopic and thermal characterization
[作者:Mohamed, GG; Omar, MM; Ibrahim, AA,期刊:European Journal of Medicinal Chemistry, 页码:4801-4812 , 文章类型: Article,,卷期:2009年44-12]
- Metal complexes of novel Schiff base (HL) ligand, prepared via condensation of 4-aminoantipyrine and 2-aminophenol, are prepared. The ligand is characterized based on elemental analysis, mass, IR and H-1 NMR spectra. Met...
- Enaminonitrile in heterocyclic synthesis: Synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety
[作者:Bondock, S; Fadaly, W; Metwally, MA,期刊:European Journal of Medicinal Chemistry, 页码:4813-4818 , 文章类型: Article,,卷期:2009年44-12]
- Enaminonitrile 2 was used as key intermediate for the synthesis of polyfunctionally substituted heterocycles (e.g. pyrazoles, isoxazole, pyrimidines, thiazolo[3,2-a]pyrimidine, tetrazolo[1,5-a]pyrimidine, pyrido[1,2-a]py...
- Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Design, chemistry and activity evaluation. Part I
[作者:Li, QB; Fang, H; Wang, XJ; Hu, LP; Xu, WF,期刊:European Journal of Medicinal Chemistry, 页码:4819-4825 , 文章类型: Article,,卷期:2009年44-12]
- A series of aminopeptidase inhibitors with cyclic-imide scaffold are described. The biological characterization for the piperidinedione analogues revealed that most compounds displayed high inhibitory activity against AP...
- Synthesis and pharmacological evaluation of novel N-alkyl/aryl substituted thiazolidinone arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia models
[作者:Sadashiva, CT; Chandra, JNNS; Kavitha, CV; Thimmegowda, A; Subhash, MN; Rangappa, KS,期刊:European Journal of Medicinal Chemistry, 页码:4848-4854 , 文章类型: Article,,卷期:2009年44-12]
- Earlier we have reported the effect of arecoline thiazolidinone and morpholino arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia models. To elucidate further our SAR study on the chemistry and ...
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