- An in vitro characterization study of new near infrared dyes for molecular imaging
[作者:Pauli, J; Vag, T; Haag, R; Spieles, M; Wenzel, M; Kaiser, WA; Resch-Genger, U; Hilger, I,期刊:European Journal of Medicinal Chemistry, 页码:3496-3503 , 文章类型: Article,,卷期:2009年44-9]
- The spectroscopic properties, stability, and cytotoxicity of series of cyanine labels, the dyes DY-681, DY-731, DY-751, and DY-776, were studied to identify new tools for in vivo fluorescence imaging and to find substitu...
- Synthesis and anti-tumor activities of some new pyridines and pyrazolo [1,5-a]pyrimidines
[作者:Ahmed, OM; Mohamed, MA; Ahmed, RR; Ahmed, SA,期刊:European Journal of Medicinal Chemistry, 页码:3519-3523 , 文章类型: Article,,卷期:2009年44-9]
- Cyclocondensation of cyanoacetamide, cyanothioacetamide and 3-aminopyrazols with sodium salt of 3-hydroxy-1-(2-naphthyl)prop-2-en-1-one gives pyridin-2-one, pyridin-2(1H)-thione, and pyrazolo[1,5-a]pyrimidine derivatives...
- Discovering a new analogue of thalidomide which may be used as a potent modulator of TNF-alpha production
[作者:Brana, MF; Acero, N; Anorbe, L; Mingarro, DM; Llinares, F; Dominguez, G,期刊:European Journal of Medicinal Chemistry, 页码:3533-3542 , 文章类型: Article,,卷期:2009年44-9]
- A new series of imide derivatives related to thalidomide were synthesized and evaluated as modulators of TNF-alpha production. These derivatives enhance TNF-a production using human leukemia HL-60 cells induced with 12-O...
- Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes
[作者:Patrick, DA; Bakunov, SA; Bakunova, SM; Kumar, EVKS; Chen, H; Jones, SK; Wenzler, T; Barzczc, T; Werbovetz, KA; Brun, R; Tidwell, RR,期刊:European Journal of Medicinal Chemistry, 页码:3543-3551 , 文章类型: Article,,卷期:2009年44-9]
- A series of 37 dicationically substituted bis(phenoxymethyl)benzene bis(phenoxymethyl)naphthalene, and bis(benzyloxy)naphthalene analogues of pentamidine was prepared and evaluated for antiprotozoal activities and cytoto...
- Synthesis, spectral characterization, in-vitro microbiological evaluation and cytotoxic activities of novel macrocyclic bis hydrazone
[作者:Avaji, PG; Kumar, CHV; Patil, SA; Shivananda, KN; Nagaraju, C,期刊:European Journal of Medicinal Chemistry, 页码:3552-3559 , 文章类型: Article,,卷期:2009年44-9]
- A macrocyclic hydrazone Schiff base was synthesized by reacting 1,4-dicarbonyl phenyl dihydrazide with 2,6-diformyl-4-methyl phenol and a series of metal complexes with this new Schiff base were synthesized by reaction w...
- Phenethyl pyridines with non-polar internal substitutents as selective ligands for estrogen receptor beta
[作者:Waibel, M; Kieser, KJ; Carlson, KE; Stossi, F; Katzenellenbogen, BS; Katzenellenbogen, JA,期刊:European Journal of Medicinal Chemistry, 页码:3560-3570 , 文章类型: Article,,卷期:2009年44-9]
- To create estrogen receptor beta (ERO)-selective ligands with improved biological characteristics, we have extended our investigations of structurally simple bibenzyl-core ligands by preparing a series of compounds in wh...
- Synthesis and cytotoxic profile of glycosyl-triazole linked to 1,2,4-oxadiazole moiety at C-5 through a straight-chain carbon and oxygen atoms
[作者:dos Anjos, JV; Neves, RAW; do Nascimento, SC; Srivastava, RM; de Melo, SJ; Sinou, D,期刊:European Journal of Medicinal Chemistry, 页码:3571-3576 , 文章类型: Article,,卷期:2009年44-9]
- The convergent synthesis of an unusual (but simple) class of compounds 5a-g has been achieved by the copper-catalyzed [3 + 2] cycloaddition reaction of 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl azide 4 with propynyl 3...
- Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide
[作者:Karakus, S; Kucukguzel, SG; Kucukguzel, I; De Clercq, E; Pannecouque, C; Andrei, G; Snoeck, R; Sahin, F; Bayrak, OF,期刊:European Journal of Medicinal Chemistry, 页码:3591-3595 , 文章类型: Article,,卷期:2009年44-9]
- Due to a continuing effort to develop new antiviral agents, a series of 1-[4-(methanesulfonamido)-3-phenoxyphenyl]-3-alkyl/aryl thioureas 3a-i have been synthesized by the reaction of alkyl/aryl isothiocyanates with 4-am...
- Synthesis and evaluation of anti-tumor activities of N-4 fatty acyl amino acid derivatives of 1-beta-arabinofuranosylcytosine
[作者:Liu, BY; Cui, CY; Duan, W; Zhao, M; Peng, SQ; Wang, LL; Liu, H; Cui, GH,期刊:European Journal of Medicinal Chemistry, 页码:3596-3600 , 文章类型: Article,,卷期:2009年44-9]
- 1-beta-D-Arabinofuranosylcytosine (Ara-C, Cytarabine) is one of the drugs used for acute nonlympbocytic leukemia (ANLL). However, the bioavailability of Ara-C is relatively low due to its low lipophilicity. In order to i...
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