- Identification of hydrolytically stable and selective P2Y(1) receptor agonists
[作者:Eliahu, SE; Camden, J; Lecka, J; Weisman, GA; Sevigny, J; Gelinas, S; Fischer, B,期刊:European Journal of Medicinal Chemistry, 页码:1525-1536 , 文章类型: Article,,卷期:2009年44-4]
- P2Y nucleotide receptors (P2YRs) are attractive pharmaceutical targets. Most P2YR agonists proposed as drugs consist of a nucleotide scaffold, but their use is limited due to their chemical and enzymatic instabilities. T...
- Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine
[作者:Mitic, D; Milenkovic, M; Milosavljevic, S; Godevac, D; Miodragovic, Z; Andelkovic, K; Miodragovic, D,期刊:European Journal of Medicinal Chemistry, 页码:1537-1544 , 文章类型: Article,,卷期:2009年44-4]
- In this paper the first complexes of M2+ ions (M2+ = Zn2+, Cd2+ and Co2+) with N-benzyloxycarbonyl-S-phenylalaninato ligand (1-3) are described. The new complexes were characterized by means of elemental analysis, IR and...
- Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: Electrochemical behaviour and ESR spectroscopic studies
[作者:Rodriguez, J; Gerpe, A; Aguirre, G; Kemmerling, U; Piro, OE; Aran, VJ; Maya, JD; Olea-Azar, C; Gonzalez, M; Cerecetto, H,期刊:European Journal of Medicinal Chemistry, 页码:1545-1553 , 文章类型: Article,,卷期:2009年44-4]
- New indazole derivatives have been developed to know about structural requirements for adequate anti-Trypanosoma cruzi activity. In relation to position 1 of indazole ring, we have observed that a butylaminopentyl substi...
- The porphyrin-fullerene nanoparticles to promote the ATP overproduction in myocardium: Mg-25(2+)-magnetic isotope effect
[作者:Rezayat, SM; Boushehri, SVS; Salmanian, B; Omidvari, AH; Tarighat, S; Esmaeili, S; Sarkar, S; Amirshahi, N; Alyautdin, RN; Orlova, MA; Trushkov, IV; Buchachenko, AL; Liu, KC; Kuznetsov, DA,期刊:European Journal of Medicinal Chemistry, 页码:1554-1569 , 文章类型: Article,,卷期:2009年44-4]
- This is a first case ever reported on the fullerene-based low toxic nanocationite particles (porphyrin adducts of cyclohexyl fullerene-C-60) designed for targeted delivery of the paramagnetic magnesium stable isotope to ...
- Design, synthesis, structure-activity relationship and antibacterial activity series of novel imidazo fused quinolone carboxamides
[作者:Reddy, GV; Kanth, SR; Maitraie, D; Narsaiah, B; Rao, PS; Kishore, KH; Murthy, USN; Ravi, B; Kumar, BA; Parthasarathy, T,期刊:European Journal of Medicinal Chemistry, 页码:1570-1578 , 文章类型: Article,,卷期:2009年44-4]
- A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated against antibacterial activity. 1,8 Imidazo fused quinolones exhibit moderate antibacterial activity. Molecular modeling st...
- Synthesis and in vitro antitumor activity of new quinoxaline derivatives
[作者:Corona, P; Carta, A; Loriga, M; Vitale, G; Paglietti, G,期刊:European Journal of Medicinal Chemistry, 页码:1579-1591 , 文章类型: Article,,卷期:2009年44-4]
- A series of novel 5,7-diamino-3-phenyl-2-benzylamino, 2-phenoxy, and 2-thiophenyl substituted quinoxalines has been designed, synthesized and evaluated for their in vitro antitumor activity towards cell lines of nine dif...
- Photodynamic inactivation of Candida albicans sensitized by tri- and tetra-cationic porphyrin derivatives
[作者:Cormick, MP; Alvarez, MG; Rovera, M; Durantini, EN,期刊:European Journal of Medicinal Chemistry, 页码:1592-1599 , 文章类型: Article,,卷期:2009年44-4]
- The photodynamic action of 5-(4-trifluorophenyl)-10,15,20-tris(4-trimethylammoniumphenyl)porphyrin iodide (TFAP(3+)) and 5,10,15,20-tetra(4-N,N,N-trimethylammonium phenyl)porphyrin p-tosylate (TMAP(4+)) has been studied ...
- First-principle, structure-based prediction of hepatic metabolic clearance values in human
[作者:Li, HY; Sun, J; Sui, XF; Liu, JF; Yan, ZT; Liu, XH; Sun, YH; He, ZG,期刊:European Journal of Medicinal Chemistry, 页码:1600-1606 , 文章类型: Article,,卷期:2009年44-4]
- The first-principle, quantitative structure-hepatic clearance relationship for 50 drugs was constructed based on selected molecular descriptors calculated by TSAR software. The R-2 of the predicted and observed hepatic c...
- Synthesis, structure and biological activity of copper(II) complexes of 4-(2-pyridylmethyl)-1,7-dimethyl-1,4,7-triazonane-2,6-dione and 4-(2-pyridylethyl)-1,7-dimethyl-1,4,7-triazonane-2,6-dione
[作者:Singh, AP; Kaushik, NK; Verma, AK; Hundal, G; Gupta, R,期刊:European Journal of Medicinal Chemistry, 页码:1607-1614 , 文章类型: Article,,卷期:2009年44-4]
- Four mononuclear copper(II) complexes 1-4 have been synthesized with two new N-functionalized macrocyclic ligands L-1 and L-2. All complexes are well characterized by various spectroscopic techniques, elemental analyses ...
- Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones
[作者:Gligorijevic, N; Todorovic, T; Radulovic, S; Sladic, D; Filipovic, N; Godevac, D; Jeremic, D; Andelkovic, K,期刊:European Journal of Medicinal Chemistry, 页码:1623-1629 , 文章类型: Article,,卷期:2009年44-4]
- New complexes of Pt(II) and Pd(II) with 2-quinolinecarboxaldehyde selenosemicarbazone were synthesized and characterized by elemental analysis, NMR and IR spectroscopy and molar conductivity measurements. The assumed geo...
- Hydroxychalcones induce apoptosis in B16-F10 melanoma cells via GSH and ATP depletion
[作者:Navarini, ALF; Chiaradia, LD; Mascarello, A; Fritzen, M; Nunes, RJ; Yunes, RA; Creczynski-Pasa, TB,期刊:European Journal of Medicinal Chemistry, 页码:1630-1637 , 文章类型: Article,,卷期:2009年44-4]
- Searching for leading compounds of new drugs for cancer therapy, we studied the toxicity of 13 hydroxychalcones never tested before toward melanoma cell line (B16-F10). The compounds were obtained by aldolic condensation...
- 2-Azetidinone derivatives: Design, synthesis and evaluation of cholesterol absorption inhibitors
[作者:Wang, YB; Zhang, HB; Huang, WL; Kong, J; Zhou, JP; Zhang, BB,期刊:European Journal of Medicinal Chemistry, 页码:1638-1643 , 文章类型: Article,,卷期:2009年44-4]
- Fourteen new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been synthesized, and three of them were enantiomerically pure. All the new compounds were evaluated for their activity to inhibit chol...
- Novel modifications in the series of O-(2-phthalimidoethyl)-N-substituted thiocarbamates and their ring-opened congeners as non-nucleoside HIV-1 reverse transcriptase inhibitors
[作者:Spallarossa, A; Cesarini, S; Ranise, A; Bruno, O; Schenone, S; La Colla, P; Collu, G; Sanna, G; Secci, B; Loddo, R,期刊:European Journal of Medicinal Chemistry, 页码:1650-1663 , 文章类型: Article,,卷期:2009年44-4]
- The structure-activity relationships (SARs) of N-aryl-O-(2-phthalimidoethyl)thiocarbamates (C-TCs) and their imide ring-opened congeners (O-TCs) as non-nucleoside HIV-1 reverse transcriptase inhibitors were further inves...
|