- Structure of the PTEN-like Region of Auxilin, a Detector of Clathrin-Coated Vesicle Budding
[作者：Guan, R; Han, D; Harrison, SC; Kirchhausen, T,期刊：Structure, 页码：1191-1198 , 文章类型： Article，,卷期：2010年18-9]
- Auxilin, a J-domain containing protein, recruits the Hsc70 uncoating ATPase to newly budded clathrin-coated vesicles. The timing of auxilin arrival determines that uncoating will commence only after the clathrin lattice ...
- PagP Crystallized from SDS/Cosolvent Reveals the Route for Phospholipid Access to the Hydrocarbon Ruler
[作者：Cuesta-Seijo, JA; Neale, C; Khan, MA; Moktar, J; Tran, CD; Bishop, RE; Pomes, R; Prive, GG,期刊：Structure, 页码：1210-1219 , 文章类型： Article，,卷期：2010年18-9]
- Enzymatic reactions involving bilayer lipids occur in an environment with strict physical and topological constraints. The integral membrane enzyme PagP transfers a palmitoyl group from a phospholipid to lipid A in order...
- Systematic Bioinformatics and Experimental Validation of Yeast Complexes Reduces the Rate of Attrition during Structural Investigations
[作者：Brooks, MA; Gewartowski, K; Mitsiki, E; Letoquart, J; Pache, RA; Billier, Y; Bertero, M; Correa, M; Czarnocki-Cieciura, M; Dadlez, M; Henriot, V; Lazar, N; Delbos, L; Lebert, D; Piwowarski, J; Rochaix, P; Bottcher, B; Serrano, L; Seraphin, B; van Tilbeurgh, H; Aloy, P; Perrakis, A; Dziembowski, A,期刊：Structure, 页码：1075-1082 , 文章类型： Article，,卷期：2010年18-9]
- For high-throughput structural studies of protein complexes of composition inferred from proteomics data, it is crucial that candidate complexes are selected accurately. Herein, we exemplify a procedure that combines a b...
- Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism
[作者：ter Haar, E; Koth, CM; Abdul-Manan, N; Swenson, L; Coll, JT; Lippke, JA; Lepre, CA; Garcia-Guzman, M; Moore, JM,期刊：Structure, 页码：1083-1093 , 文章类型： Article，,卷期：2010年18-9]
Dysregulation of the calcitonin gene-related peptide (CGRP), a potent vasodilator, is directly implicated in the pathogenesis of migraine. CGRP binds to and signals through the CGRP receptor (CGRP-R), a heterodimer co...
- Structural Diversity in Free and Bound States of Intrinsically Disordered Protein Phosphatase 1 Regulators
[作者：Marsh, JA; Dancheck, B; Ragusa, MJ; Allaire, M; Forman-Kay, JD; Peti, W,期刊：Structure, 页码：1094-1103 , 文章类型： Article，,卷期：2010年18-9]
- Complete folding is not a prerequisite for protein function, as disordered and partially folded states of proteins frequently perform essential biological functions. In order to understand their functions at the molecula...
- Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity
[作者：Moulaei, T; Shenoy, SR; Giomarelli, B; Thomas, C; McMahon, JB; Dauter, Z; O'Keefe, BR; Wlodawer, A,期刊：Structure, 页码：1104-1115 , 文章类型： Article，,卷期：2010年18-9]
- Mutations were introduced to the domain-swapped homodimer of the antiviral lectin griffithsin (GRFT). Whereas several single and double mutants remained dimeric, insertion of either two or four amino acids at the dimeriz...
- Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope
[作者：Correia, BE; Ban, YEA; Holmes, MA; Xu, HY; Ellingson, K; Kraft, Z; Carrico, C; Boni, E; Sather, DN; Zenobia, C; Burke, KY; Bradley-Hewitt, T; Bruhn-Johannsen, JF; Kalyuzhniy, O; Baker, D; Strong, RK; Stamatatos, L; Schief, WR,期刊：Structure, 页码：1116-1126 , 文章类型： Article，,卷期：2010年18-9]
- Broadly cross-reactive monoclonal antibodies define epitopes for vaccine development against HIV and other highly mutable viruses. Crystal structures are available for several such antibody-epitope complexes, but methods...
- Structural Insight into the Zinc Finger CW Domain as a Histone Modification Reader
[作者：He, FH; Umehara, T; Saito, K; Harada, T; Watanabe, S; Yabuki, T; Kigawa, T; Takahashi, M; Kuwasako, K; Tsuda, K; Matsuda, T; Aoki, M; Seki, E; Kobayashi, N; Guntert, P; Yokoyama, S; Muto, Y,期刊：Structure, 页码：1127-1139 , 文章类型： Article，,卷期：2010年18-9]
- The zinc finger CW (zf-CW) domain is a motif of about 60 residues that is frequently found in proteins involved in epigenetic regulation. Here, we determined the NMR solution structure of the zf-CW domain of the human zf...
- Structure and Cellular Roles of the RMI Core Complex from the Bloom Syndrome Dissolvasome
[作者：Hoadley, KA; Xu, DY; Xue, YT; Satyshur, KA; Wang, WD; Keck, JL,期刊：Structure, 页码：1149-1158 , 文章类型： Article，,卷期：2010年18-9]
- BLM, the protein product of the gene mutated in Bloom syndrome, is one of five human RecQ helicases. It functions to separate double Holliday junction DNA without genetic exchange as a component of the "dissolvasome," wh...
- Crystal Structures of RMI1 and RMI2, Two OB-Fold Regulatory Subunits of the BLM Complex
[作者：Wang, F; Yang, YT; Singh, TR; Busygina, V; Guo, R; Wan, K; Wang, WD; Sung, P; Meetei, AR; Lei, M,期刊：Structure, 页码：1159-1170 , 文章类型： Article，,卷期：2010年18-9]
Mutations in BLM, a RecQ-like helicase, are linked to the autosomal recessive cancer-prone disorder Bloom's syndrome. BLM associates with topoisomerase (Topo) Ill alpha, RMI1, and RMI2 to form the BLM complex that is ...
- Quantitative Structural Analysis of Importin-beta Flexibility: Paradigm for Solenoid Protein Structures
[作者：Forwood, JK; Lange, A; Zachariae, U; Marfori, M; Preast, C; Grubmuller, H; Stewart, M; Corbett, AH; Kobe, B,期刊：Structure, 页码：1171-1183 , 文章类型： Article，,卷期：2010年18-9]
- The structure of solenoid proteins facilitates a higher degree of flexibility than most folded proteins. In importin-beta, a nuclear import factor built from 19 tandem HEAT repeats, flexibility plays a crucial role in al...
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