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Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity
[作者：Sarma, GN; Kinderman, FS; Kim, C; von Daake, S; Chen, LR; Wang, BC; Taylor, SS,期刊：Structure, 页码：155-166 , 文章类型： Article，,卷期：2010年18-2]
A-kinase anchoring proteins (AKAPs) regulate cyclic AMP-dependent protein kinase (PKA) signaling in space and time. Dual-specific AKAP 2 (D-AKAP2) binds to the dimerization/docking (D/D) domain of both RI and RII regulat...

Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
[作者：Campbell, SJ; Edwards, RA; Glover, JNM,期刊：Structure, 页码：167-176 , 文章类型： Article，,卷期：2010年18-2]
The tandem BRCT domains of BRCA1 and MDC1 facilitate protein signaling at DNA damage foci through specific interactions with serine-phosphorylated protein partners. The MDC1 BRCT binds pSer-Gln-Glu-Tyr-COO- at the C term...

Structural Basis for DNA Strand Separation by the Unconventional Winged-Helix Domain of RecQ Helicase WRN
[作者：Kitano, K; Kim, SY; Hakoshima, T,期刊：Structure, 页码：177-187 , 文章类型： Article，,卷期：2010年18-2]
The RecQ family of DNA helicases including WRN (Werner syndrome protein) and BLM (Bloom syndrome protein) protects the genome against deleterious changes. Here we report the cocrystal structure of the RecQ C-terminal (RQ...

The Structural Basis of Peptide-Protein Binding Strategies
[作者：London, N; Movshovitz-Attias, D; Schueler-Furman, O,期刊：Structure, 页码：188-199 , 文章类型： Article，,卷期：2010年18-2]
Peptide-protein interactions are very prevalent, mediating key processes such as signal transduction and protein trafficking. How can peptides overcome the entropic cost involved in switching from an unstructured, flexib...

SusG: A Unique Cell-Membrane-Associated alpha-Amylase from a Prominent Human Gut Symbiont Targets Complex Starch Molecules
[作者：Koropatkin, NM; Smith, TJ,期刊：Structure, 页码：200-215 , 文章类型： Article，,卷期：2010年18-2]
SusG is an alpha-amylase and part of a large protein complex on the outer surface of the bacterial cell and plays a major role in carbohydrate acquisition by the animal gut microbiota. Presented here, the atomic structur...

Structure of the Saccharomyces cerevisiae Cet1-Ceg1 mRNA Capping Apparatus
[作者：Gu, MG; Rajashankar, KR; Lima, CD,期刊：Structure, 页码：216-227 , 文章类型： Article，,卷期：2010年18-2]
The 5' guanine-N7 cap is the first cotranscriptional modification of messenger RNA. In Saccharomyces cerevisiae, the first two steps in capping are catalyzed by the RNA triphosphatase Cet1 and RNA guanylyltransferase Ceg...

Crystal Structure of a Legionella pneumophila Ecto-Triphosphate Diphosphohydrolase, A Structural and Functional Homolog of the Eukaryotic NTPDases
[作者：Vivian, JP; Riedmaier, P; Ge, HH; Le Nours, J; Sansom, FM; Wilce, MCJ; Byres, E; Dias, M; Schmidberger, JW; Cowan, PJ; d'Apice, AJF; Hartland, EL; Rossjohn, J; Beddoe, T,期刊：Structure, 页码：228-238 , 文章类型： Article，,卷期：2010年18-2]
Many pathogenic bacteria have sophisticated mechanisms to interfere with the mammalian immune response. These include the disruption of host extracellular ATP levels that, in humans, is tightly regulated by the nucleo...

Structural Interactions between Collagen and Proteoglycans Are Elucidated by Three-Dimensional Electron Tomography of Bovine Cornea
[作者：Lewis, PN; Pinali, C; Young, RD; Meek, KM; Quantock, AJ; Knupp, C,期刊：Structure, 页码：239-245 , 文章类型： Article，,卷期：2010年18-2]
Interactions between collagens and proteoglycans help define the structure and function of extracellular matrices. The cornea, which contains proteoglycans with keratan sulphate or chondroitin/dermatan sulphate glycosami...

Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer
[作者：Chen, YH; Dey, R; Chen, L,期刊：Structure, 页码：246-256 , 文章类型： Article，,卷期：2010年18-2]
Recent studies suggest that p53 binds predominantly to consensus sites composed of two decameric half-sites with zero spacing in vivo. Here we report the crystal structure of the p53 core domain bound to a full consen...

Direct Observation of Distinct A/P Hybrid-State tRNAs in Translocating Ribosomes
[作者：Flanagan, JF; Namy, O; Brierley, I; Gilbert, RJC,期刊：Structure, 页码：257-264 , 文章类型： Article，,卷期：2010年18-2]
Transfer RNAs (tRNAs) link the genetic code in the form of messenger RNA (mRNA) to protein sequence. Translocation of tRNAs through the ribosome from aminoacyl (A) site to peptidyl (P) site and from P site to exit site i...

AlgK Is a TPR-Containing Protein and the Periplasmic Component of a Novel Exopolysaccharide Secretin
[作者：Keiski, CL; Harwich, M; Jain, S; Neculai, AM; Yip, P; Robinson, H; Whitney, JC; Riley, L; Burrows, LL; Ohman, DE; Howell, PL,期刊：Structure, 页码：265-273 , 文章类型： Article，,卷期：2010年18-2]
The opportunistic pathogen Pseudomonas aeruginosa causes chronic biofilm infections in cystic fibrosis patients. During colonization of the lung, A aeruginosa converts to a mucoid phenotype characterized by overproductio...