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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Local and Global Mobility in the ClpA AAA plus Chaperone Detected by Cryo-Electron Microscopy: Functional Connotations [作者：Effantin, G; Ishikawa, T; De Donatis, GM; Maurizi, MR; Steven, AC,期刊：Structure, 页码：553-562 , 文章类型： Article，,卷期：2010年18-5] The ClpA chaperone combines with the CIpP peptidase to perform targeted proteolysis in the bacterial cytoplasm. ClpA monomer has an N-terminal substrate-binding domain and two AAA+ ATPase domains (D1 and D2). ClpA hexame... A Single Mutation Promotes Amyloidogenicity through a Highly Promiscuous Dimer Interface [作者：Peterson, FC; Baden, EM; Owen, BAL; Volkman, BF; Ramirez-Alvaradoz, M,期刊：Structure, 页码：563-570 , 文章类型： Article，,卷期：2010年18-5] Light chain amyloidosis is a devastating protein misfolding disease characterized by the accumulation of amyloid fibrils that causes tissue damage and organ failure. These fibrils are composed of monoclonal light chain p... Structure of an Apoptosome-Procaspase-9 CARD Complex [作者：Yuan, SJ; Yu, XC; Topf, M; Ludtke, SJ; Wang, XD; Akey, CW,期刊：Structure, 页码：571-583 , 文章类型： Article，,卷期：2010年18-5] Apaf-1 coassembles with cytochrome c to form the apoptosome, which then binds and activates procaspase-9 (pc-9). We removed pc-9 catalytic domains from the holoapoptosome by site-directed thrombinolysis. A structure of t... The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for Its Function [作者：Vander Kooi, CW; Ren, LP; Xu, P; Ohi, MD; Gould, KL; Chazin, WJ,期刊：Structure, 页码：584-593 , 文章类型： Article，,卷期：2010年18-5] Prp19 is a member of the WD40 repeat family of E3 ubiquitin ligases and a conserved eukaryotic RNA splicing factor essential for activation and stabilization of the spliceosome. To understand the role of the WD40 repeat ... Structural Analysis of the RZZ Complex Reveals Common Ancestry with Multisubunit Vesicle Tethering Machinery [作者：Civril, F; Wehenkel, A; Giorgi, FM; Santaguida, S; Di Fonzo, A; Grigorean, G; Ciccarelli, FD; Musacchio, A,期刊：Structure, 页码：616-626 , 文章类型： Article，,卷期：2010年18-5] The RZZ complex recruits dynein to kinetochores. We investigated structure, topology, and interactions of the RZZ subunits (ROD, ZWILCH, and ZW10) in vitro, in vivo, and in silico. We identify neuroblastoma-amplified gen... Structure of Arabidopsis HYPONASTIC LEAVES1 and Its Molecular Implications for miRNA Processing [作者：Yang, SW; Chen, HY; Yang, J; Machida, S; Chua, NH; Yuan, YA,期刊：Structure, 页码：594-605 , 文章类型： Article，,卷期：2010年18-5] The Arabidopsis HYPONASTIC LEAVES1 (HYL1) is a double-stranded RNA-binding protein that forms a complex with DICER-LIKE1 (DCL1) and SERRATE to facilitate processing of primary miRNAs into microRNAs (miRNAs). However, the... The Structure of PknB Extracellular PASTA Domain from Mycobacterium tuberculosis Suggests a Ligand-Dependent Kinase Activation [作者：Barthe, P; Mukamolova, GV; Roumestand, C; Cohen-Gonsaud, M,期刊：Structure, 页码：606-615 , 文章类型： Article，,卷期：2010年18-5] PknB is a transmembrane Ser/Thr protein kinase that defines and belongs to an ultraconserved kinase subfamily found in Gram-positive bacteria. Essential for Mycobacterium tuberculosis growth, its close homolog in Bacillu... Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain [作者：Yoon, SI; Jones, BC; Logsdon, NJ; Harris, BD; Deshpande, A; Radaeva, S; Halloran, BA; Gao, B; Walter, MR,期刊：Structure, 页码：638-648 , 文章类型： Article，,卷期：2010年18-5] IL-10R2 is a shared cell surface receptor required for the activation of five class 2 cytokines (IL-10, IL-22, IL-26, IL-28, and IL-29) that play critical roles in host defense. To define the molecular mechanisms that re... Two-State Conformations in the Hyaluronan-Binding Domain Regulate CD44 Adhesiveness under Flow Condition [作者：Ogino, S; Nishida, N; Umemoto, R; Suzuki, M; Takeda, M; Terasawa, H; Kitayama, J; Matsumoto, M; Hayasaka, H; Miyasaka, M; Shimada, I,期刊：Structure, 页码：649-656 , 文章类型： Article，,卷期：2010年18-5] The hyaluronan (HA) receptor CD44 mediates cell adhesion in leukocyte trafficking and tumor metastasis. Our previous nuclear magnetic resonance (NMR) studies revealed that the CD44 hyaluronan-binding domain (HABD) alters... Recognition of the Regulatory Nascent Chain TnaC by the Ribosome [作者：Trabuco, LG; Harrison, CB; Schreiner, E; Schulten, K,期刊：Structure, 页码：627-637 , 文章类型： Article，,卷期：2010年18-5] Regulatory nascent chains interact with the ribosomal exit tunnel and modulate their own translation. To characterize nascent chain recognition by the ribosome at the atomic level, extensive molecular dynamics simulation...