- Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379
[作者：Lovly, CM; Yan, L; Ryan, CE; Takada, S; Piwnica-Worms, H,期刊：Molecular and Cellular Biology, 页码：5874-5885 , 文章类型： Article，,卷期：2008年28-19]
- The Chk2 protein kinase protects genome integrity by promoting cell cycle arrest or apoptosis in response to DNA double-strand breaks, and Chk2 mutations are found in both familial and sporadic cancers. Exposure of cells...
- The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression
[作者：Hui, RCY; Gomes, AR; Constantinidou, D; Costa, JR; Karadedou, CT; de Mattos, SF; Wymann, MP; Brosens, JJ; Schulze, A; Lam, EWF,期刊：Molecular and Cellular Biology, 页码：5886-5898 , 文章类型： Article，,卷期：2008年28-19]
- The phosphoinositide-3 kinase (PI3K)/Akt signal pathway plays a key role in the tumorigenesis of many cancers and in the subsequent development of drug resistance. Using the K562 chronic myelogenous leukemia (CML) cell l...
- Crystal structure of human Edc3 and its functional implications
[作者：Ling, SHM; Decker, CJ; Walsh, MA; She, MP; Parker, R; Song, HW,期刊：Molecular and Cellular Biology, 页码：5965-5976 , 文章类型： Article，,卷期：2008年28-19]
- Edc3 is an enhancer of decapping and serves as a scaffold that aggregates mRNA ribonucleoproteins together for P-body formation. Edc3 forms a network of interactions with the components of the mRNA decapping machinery an...
- The DNA replication checkpoint directly regulates MBF-dependent G(1)/S transcription
[作者：Dutta, C; Patel, PK; Rosebrock, A; Oliva, A; Leatherwood, J; Rhind, N,期刊：Molecular and Cellular Biology, 页码：5977-5985 , 文章类型： Article，,卷期：2008年28-19]
- The DNA replication checkpoint transcriptionally upregulates genes that allow cells to adapt to and survive replication stress. Our results show that, in the fission yeast Schizosaccharomyces pombe, the replication check...
- Multiple and specific mRNA processing targets for the major human hnRNP proteins
[作者：Venables, JP; Koh, CS; Froehlich, U; Lapointe, E; Couture, S; Inkel, L; Bramard, A; Paquet, ER; Watier, V; Durand, M; Lucier, JF; Gervais-Bird, J; Tremblay, K; Prinos, P; Klinck, R; Abou Elela, S; Chabot, B,期刊：Molecular and Cellular Biology, 页码：6033-6043 , 文章类型： Article，,卷期：2008年28-19]
- Alternative splicing is a key mechanism regulating gene expression, and it is often used to produce antagonistic activities particularly in apoptotic genes. Heterogeneous nuclear ribonucleoparticle (hnRNP) proteins form ...
- Apoptosis and autophagy induction in mammalian cells by small interfering RNA knockdown of mRNA capping enzymes
[作者：Chu, C; Shatkin, AJ,期刊：Molecular and Cellular Biology, 页码：5829-5836 , 文章类型： Article，,卷期：2008年28-19]
- Addition of a 5' cap to RNA polymerase II transcripts, the first step of pre-mRNA processing in eukaryotes from yeasts to mammals, is catalyzed by the sequential action of RNA triphosphatase, guanylyltransferase, and (gu...
- Regulation of acetylation at the major histocompatibility complex class II proximal promoter by the 19S proteasomal ATPase Sug1
[作者：Koues, OI; Dudley, RK; Truax, AD; Gerhardt, D; Bhat, KP; McNeal, S; Greer, SF,期刊：Molecular and Cellular Biology, 页码：5837-5850 , 文章类型： Article，,卷期：2008年28-19]
- Recent studies have made evident the fact that the 19S regulatory component of the proteasome has functions that extend beyond degradation, particularly in the regulation of transcription. Although 19S ATPases facilitate...
- MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks
[作者：Morey, L; Brenner, C; Fazi, F; Villa, R; Gutierrez, A; Buschbeck, M; Nervi, C; Minucci, S; Fuks, F; Di Croce, L,期刊：Molecular and Cellular Biology, 页码：5912-5923 , 文章类型： Article，,卷期：2008年28-19]
- In plants, as in mammals, mutations in SNF2-like DNA helicases/ATPases were shown to affect not only chromatin structure but also global methylation patterns, suggesting a potential functional link between chromatin stru...
- Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression
[作者：van den Berg, DLC; Zhang, WS; Yates, A; Engelen, E; Takacs, K; Bezstarosti, K; Demmers, J; Chambers, I; Poot, RA,期刊：Molecular and Cellular Biology, 页码：5986-5995 , 文章类型： Article，,卷期：2008年28-19]
- Embryonic stem (ES) cell self-renewal is regulated by transcription factors, including Oct4, Sox2, and Nanog. A number of additional transcriptional regulators of ES cell self-renewal have recently been identified, inclu...
- Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling
[作者：Nakamura, A; Naito, M; Tsuruo, T; Fujita, N,期刊：Molecular and Cellular Biology, 页码：5996-6009 , 文章类型： Article，,卷期：2008年28-19]
- The phosphoinositide 3-kinase (PI3K)/3-phosphoinositide-dependent protein kinase 1 (PDK1)/Akt pathway regulates various cellular functions, especially cell survival and cell cycle progression. In contrast to other surviv...
- Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex
[作者：Lee, J; Lee, Y; Lee, MJ; Park, E; Kang, SH; Chung, CH; Lee, KH; Kim, K,期刊：Molecular and Cellular Biology, 页码：6056-6065 , 文章类型： Article，,卷期：2008年28-19]
- Heterodimers of BMAL1 and CLOCK drive rhythmic expression of clock-controlled genes, thereby generating circadian physiology and behavior. Posttranslational modifications of BMAL1 play a key role in modulating the transc...
- Genome analysis identifies the p15(ink4b) tumor suppressor as a direct target of the ZNF217/CoREST complex
[作者：Thillainadesan, G; Isovic, M; Loney, E; Andrews, J; Tini, M; Torchia, J,期刊：Molecular and Cellular Biology, 页码：6066-6077 , 文章类型： Article，,卷期：2008年28-19]
- The ZNF217 oncoprotein is a constituent of a core transcriptional complex that includes CoREST, histone deacetylase 1/2, lysine demethylase 1, and the C-terminal binding protein 1/2. We have combined genome-wide expressi...
- Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability
[作者：Bochman, ML; Bell, SP; Schwacha, A,期刊：Molecular and Cellular Biology, 页码：5865-5873 , 文章类型： Article，,卷期：2008年28-19]
- The Mcm2-7 (minichromosome maintenance) complex is a toroidal AAA(+) ATPase and the putative eukaryotic replicative helicase. Unlike a typical homohexameric helicase, Mcm2-7 contains six distinct, essential, and evolutio...
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