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  • Functional Links Between A beta Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast
    [作者:Treusch, S; Hamamichi, S; Goodman, JL; Matlack, KES; Chung, CY; Baru, V; Shulman, JM; Parrado, A; Bevis, BJ; Valastyan, JS; Han, H; Lindhagen-Persson, M; Reiman, EM; Evans, DA; Bennett, DA; Olofsson, A; DeJager, PL; Tanzi, RE; Caldwell, KA; Caldwell, GA; Lindquist, S,期刊:Science, 页码:1241-1245 , 文章类型: Article,,卷期:2011年334-6060]
  • A beta (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled A beta toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide screen for toxicity modifiers id...
  • Detection of Pristine Gas Two Billion Years After the Big Bang
    [作者:Fumagalli, M; O'Meara, JM; Prochaska, JX,期刊:Science, 页码:1245-1249 , 文章类型: Article,,卷期:2011年334-6060]
  • In the current cosmological model, only the three lightest elements were created in the first few minutes after the Big Bang; all other elements were produced later in stars. To date, however, heavy elements have been ob...
  • Entangling Macroscopic Diamonds at Room Temperature
    [作者:Lee, KC; Sprague, MR; Sussman, BJ; Nunn, J; Langford, NK; Jin, XM; Champion, T; Michelberger, P; Reim, KF; England, D; Jaksch, D; Walmsley, IA,期刊:Science, 页码:1253-1256 , 文章类型: Article,,卷期:2011年334-6060]
  • Quantum entanglement in the motion of macroscopic solid bodies has implications both for quantum technologies and foundational studies of the boundary between the quantum and classical worlds. Entanglement is usually fra...
  • The Role of Carbon Dioxide During the Onset of Antarctic Glaciation
    [作者:Pagani, M; Huber, M; Liu, ZH; Bohaty, SM; Henderiks, J; Sijp, W; Krishnan, S; DeConto, RM,期刊:Science, 页码:1261-1264 , 文章类型: Article,,卷期:2011年334-6060]
  • Earth's modern climate, characterized by polar ice sheets and large equator-to-pole temperature gradients, is rooted in environmental changes that promoted Antarctic glaciation similar to 33.7 million years ago. Onset of...
  • Interhemispheric Ice-Sheet Synchronicity During the Last Glacial Maximum
    [作者:Weber, ME; Clark, PU; Ricken, W; Mitrovica, JX; Hostetler, SW; Kuhn, G,期刊:Science, 页码:1265-1269 , 文章类型: Article,,卷期:2011年334-6060]
  • The timing of the last maximum extent of the Antarctic ice sheets relative to those in the Northern Hemisphere remains poorly understood. We develop a chronology for the Weddell Sea sector of the East Antarctic Ice Sheet...
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