- MDA-7/IL-24, a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin-proteasome system, and inhibition of MDA-7/IL-24 degradation enhances the antitumor activity
[作者:Gopalan, B; Shanker, M; Scott, A; Branch, CD; Chada, S; Ramesh, R,期刊:Cancer gene therapy, 页码:1-8 , 文章类型: Article,,卷期:2008年15-1]
- Steady-state protein levels are determined by the balance between protein synthesis and degradation. Protein half-lives are determined primarily by degradation, and the major degradation pathways involve either lysosomal...
- Comparison of the E3 and L3 regions for arming oncolytic adenoviruses to achieve a high level of tumor-specific transgene expression
[作者:Robinson, M; Ge, Y; Ko, D; Yendluri, S; Laflamme, G; Hawkins, L; Jooss, K,期刊:Cancer gene therapy, 页码:9-17 , 文章类型: Article,,卷期:2008年15-1]
- Arming oncolytic adenoviral vectors with anticancer transgenes that can be expressed in a tumor-selective manner may enable the engineering of vectors with increased potency, while retaining their safety profile. Armed o...
- Modified vaccinia virus Ankara as a vector for suicide gene therapy
[作者:Erbs, P; Findeli, A; Kintz, J; Cordier, P; Hoffmann, C; Geist, M; Balloul, JM,期刊:Cancer gene therapy, 页码:18-28 , 文章类型: Article,,卷期:2008年15-1]
- Modified vaccinia virus Ankara (MVA) has been used successfully to express various antigens for the development of vaccines. Here we show that MVA can also be used as an efficient vector for the transfer of suicide genes...
- Enhancement of antitumor activity of cisplatin in human lung cancer cells by tumor suppressor FUS1
[作者:Deng, WG; Wu, G; Ueda, K; Xu, K; Roth, JA; Ji, L,期刊:Cancer gene therapy, 页码:29-39 , 文章类型: Article,,卷期:2008年15-1]
- FUS1 is a novel tumor suppressor gene located in the human chromosome 3p21.3 region. We previously showed that restoration of FUS1 function in 3p21.3-deficient human non-small-cell lung cancer (NSCLC) cells significantly...
- E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models
[作者:Cheong, SC; Wang, Y; Meng, JH; Hill, R; Sweeney, K; Kirn, D; Lemoine, NR; Hallden, G,期刊:Cancer gene therapy, 页码:40-50 , 文章类型: Article,,卷期:2008年15-1]
- The majority of clinical trials evaluating replication-selective oncolytic adenoviruses utilized mutants with immunomodulatory E3B genes deleted, likely contributing to the attenuated efficacy. We investigated whether an...
- Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity
[作者:Tanaka, F; Tominaga, K; Shiota, M; Ochi, M; Kuwamura, H; Tanigawa, T; Watanabe, T; Fujiwara, Y; Oshitani, N; Higuchi, K; Iwao, H; Arakawa, T,期刊:Cancer gene therapy, 页码:51-59 , 文章类型: Article,,卷期:2008年15-1]
- Interleukin (IL)-10 has potent biological properties including an inhibitory action on the proliferation and metastasis of various cancer cells. However, it is difficult to maintain a high concentration of this cytokine ...
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