- Special Stem Cells for Bone
[作者:Zaidi, M; Sun, L; Blair, HC,期刊:Cell Stem Cell, 页码:233-234 , 文章类型: Editorial Material,,卷期:2012年10-3]
- Mesenchymal stem cells (MSCs) are multipotential in vitro, but their endogenous properties are poorly defined. In this issue of Cell Stem Cell, Park et al. (2012) report that an MSC-like, osteolineage-directed Mx1+ popul...
- iPSCs to the Rescue in Alzheimer's Research
[作者:Choi, SH; Tanzi, RE,期刊:Cell Stem Cell, 页码:235-236 , 文章类型: Editorial Material,,卷期:2012年10-3]
- A crucial limitation to our understanding of Alzheimer's disease has been the inability to test hypotheses on live, patient-specific neurons. A recent study in Nature by Israel et al. (2012) reports that iPSC-derived neu...
- Egg Sharing for Research: A Successful Outcome for Patients and Researchers
[作者:Choudhary, M; Nesbitt, M; Burgess, L; Hyslop, L; Herbert, M; Murdoch, A,期刊:Cell Stem Cell, 页码:239-240 , 文章类型: Letter,,卷期:2012年10-3]
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- Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease
[作者:Ranganath, SH; Levy, O; Inamdar, MS; Karp, JM,期刊:Cell Stem Cell, 页码:244-258 , 文章类型: Review,,卷期:2012年10-3]
- The broad repertoire of secreted trophic and immunomodulatory cytokines produced by mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has considerable potential for the treatment of cardiovascula...
- Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration
[作者:Park, D; Spencer, JA; Koh, BI; Kobayashi, T; Fujisaki, J; Clemens, TL; Lin, CP; Kronenberg, HM; Scadden, DT,期刊:Cell Stem Cell, 页码:259-272 , 文章类型: Article,,卷期:2012年10-3]
- Mesenchymal stem cells (MSCs) commonly defined by in vitro functions have entered clinical application despite little definition of their function in residence. Here, we report genetic pulse-chase experiments that define...
- Hematopoietic Stem Cell Subtypes Expand Differentially during Development and Display Distinct Lymphopoietic Programs
[作者:Benz, C; Copley, MR; Kent, DG; Wohrer, S; Cortes, A; Aghaeepour, N; Ma, E; Mader, H; Rowe, K; Day, C; Treloar, D; Brinkman, RR; Eaves, CJ,期刊:Cell Stem Cell, 页码:273-283 , 文章类型: Article,,卷期:2012年10-3]
- Adult hematopoietic stem cells (HSCs) with serially transplantable activity comprise two subtypes. One shows a balanced output of mature lymphoid and myeloid cells; the other appears selectively lymphoid deficient. We no...
- Functional Antagonism between Sall4 and Plzf Defines Germline Progenitors
[作者:Hobbs, RM; Fagoonee, S; Papa, A; Webster, K; Altruda, F; Nishinakamura, R; Chai, L; Pandolfi, PP,期刊:Cell Stem Cell, 页码:284-298 , 文章类型: Article,,卷期:2012年10-3]
- Transcription factors required for formation of embryonic tissues often maintain their expression in adult stem cell populations, but whether their function remains equivalent is not clear. Here we demonstrate critical a...
- Genetic Regulators of a Pluripotent Adult Stem Cell System in Planarians Identified by RNAi and Clonal Analysis
[作者:Wagner, DE; Ho, JJ; Reddien, PW,期刊:Cell Stem Cell, 页码:299-311 , 文章类型: Article,,卷期:2012年10-3]
- Pluripotency is a central, well-studied feature of embryonic development, but the role of pluripotent cell regulation in somatic tissue regeneration remains poorly understood. In planarians, regeneration of entire animal...
- Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation
[作者:Singh, AM; Reynolds, D; Cliff, T; Ohtsuka, S; Mattheyses, AL; Sun, YH; Menendez, L; Kulik, M; Dalton, S,期刊:Cell Stem Cell, 页码:312-326 , 文章类型: Article,,卷期:2012年10-3]
- A general mechanism for how intracellular signaling pathways in human pluripotent cells are coordinated and how they maintain self-renewal remain to be elucidated. In this report, we describe a signaling mechanism where ...
- Alternative Polyadenylation Mediates MicroRNA Regulation of Muscle Stem Cell Function
[作者:Boutet, SC; Cheung, TH; Quach, NL; Liu, L; Prescott, SL; Edalati, A; Iori, K; Rando, TA,期刊:Cell Stem Cell, 页码:327-336 , 文章类型: Article,,卷期:2012年10-3]
- Pax3, a key myogenic regulator, is transiently expressed during activation of adult muscle stem cells, or satellite cells (SCs), and is also expressed in a subset of quiescent SCs (QSCs), but only in specific muscles. Th...
- Low Incidence of DNA Sequence Variation in Human Induced Pluripotent Stem Cells Generated by Nonintegrating Plasmid Expression
[作者:Cheng, LZ; Hansen, NF; Zhao, L; Du, YT; Zou, CL; Donovan, FX; Chou, BK; Zhou, GY; Li, SJ; Dowey, SN; Ye, ZH; Chandrasekharappa, SC; Yang, HM; Mullikin, JC; Liu, PP,期刊:Cell Stem Cell, 页码:337-344 , 文章类型: Article,,卷期:2012年10-3]
- The utility of induced pluripotent stem cells (iPSCs) as models to study diseases and as sources for cell therapy depends on the integrity of their genomes. Despite recent publications of DNA sequence variations in the i...
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