- Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway
[作者:Yang, YM; Kim, HE; Ki, SH; Kim, SG,期刊:Archives of Biochemistry and Biophysics , 页码:91-99 , 文章类型: Article,,卷期:2009年488-2]
- Adipogenesis is orchestrated by the expression of master adipogenic regulators. In particular, phosphorylation of cAMP response element binding protein (CREB) by protein kinase A promotes CREB nuclear translocation, ther...
- The calcitonin/calcitonin gene related peptide-alpha gene is not required for 1 alpha,25-dihydroxyvitamin D-3-mediated suppression of experimental autoimmune encephalomyelitis
[作者:Becklund, BR; James, BJ; Gagel, RF; DeLuca, HF,期刊:Archives of Biochemistry and Biophysics , 页码:105-108 , 文章类型: Article,,卷期:2009年488-2]
- The active form of vitamin D, 1 alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3), can suppress disease in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. Calcium appears to be a critical co...
- Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes
[作者:Pasquare, SJ; Gaveglio, VL; Giusto, NM,期刊:Archives of Biochemistry and Biophysics , 页码:121-129 , 文章类型: Article,,卷期:2009年488-2]
- In this study, phosphatidic acid (PA) metabolization is found to generate diacylglycerol (DAG), monoacylglycerol (MAG) and glycerol by the sequential action of lipid phosphate phosphatase (LPP), diacylglycerol lipase (DA...
- Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate
[作者:McGuire, JJ; Bartley, DM; Tomsho, JW; Haile, WH; Coward, JK,期刊:Archives of Biochemistry and Biophysics , 页码:140-145 , 文章类型: Article,,卷期:2009年488-2]
- Phosphorus-containing pseudopeptides, racemic at the C-terminal alpha-carbon, are potent mechanism-based inhibitors of folylpolyglutamate synthetase (FPGS). They are mimics of the tetrahedral intermediate postulated to f...
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