- Ccdc85c Encoding a Protein at Apical Junctions of Radial Glia Is Disrupted in Hemorrhagic Hydrocephalus (hhy) Mice
[作者：Mori, N; Kuwamura, M; Tanaka, N; Hirano, R; Nabe, M; Ibuki, M; Yamate, J,期刊：American Journal of Pathology, 页码：314-327 , 文章类型： Article，,卷期：2012年180-1]
- Cortical heterotopia, a malformation of the developing cortex, are a major cause of epilepsy and mental retardation in humans. Hemorrhagic hydrocephalus (hhy) mutation on mouse chromosome 12 results in subcortical hetero...
- LPS-Induced Murine Systemic Inflammation Is Driven by Parenchymal Cell Activation and Exclusively Predicted by Early MCP-1 Plasma Levels
[作者：Juskewitch, JE; Knudsen, BE; Platt, JL; Nath, KA; Knutson, KL; Brunn, GJ; Grande, JP,期刊：American Journal of Pathology, 页码：32-40 , 文章类型： Article，,卷期：2012年180-1]
- Systemic inflammation remains a major cause of morbidity and mortality in the United States, across many disease processes. One classic murine model to study this syndrome is lipopolysaccharide (LPS)-induced Toll-like re...
- Low-Dose-Rate, Low-Dose Irradiation Delays Neurodegeneration in a Model of Retinitis Pigmentosa
[作者：Otani, A; Kojima, H; Guo, CR; Oishi, A; Yoshimura, N,期刊：American Journal of Pathology, 页码：328-336 , 文章类型： Article，,卷期：2012年180-1]
- The existence of radiation hormesis is controversial. Several stimulatory effects of low-dose (ID) radiation have been reported to date; however, the effects on neural tissue or neurodegeneration remain unknown. Here, we...
- BACE2 Expression Increases in Human Neurodegenerative Disease
[作者：Holler, CJ; Webb, RL; Laux, AL; Beckett, TL; Niedowicz, DM; Ahmed, RR; Liu, YX; Simmons, CR; Dowling, ALS; Spinelli, A; Khurgel, M; Estus, S; Head, E; Hersh, LB; Murphy, MP,期刊：American Journal of Pathology, 页码：337-350 , 文章类型： Article，,卷期：2012年180-1]
- beta-Secretase, the rate-limiting enzymatic activity in the production of the amyloid-beta (A beta) peptide, is a major target of Alzheimer's disease (AD) therapeutics. There are two forms of the enzyme: beta-site A beta...
- Notch-Induced hIL-6 Production Facilitates the Maintenance of Self-Renewal of hCD34(+) Cord Blood Cells Through the Activation of Jak-PI3K-STAT3 Pathway
[作者：Choi, B; Chun, E; Kim, SY; Kim, M; Lee, KY; Kim, SJ,期刊：American Journal of Pathology, 页码：351-364 , 文章类型： Article，,卷期：2012年180-1]
- Ex vivo expansion of CD34(+) stern cells in contact culture between hCD34(+)CD38(-)Lin(-) cord blood stern cells and human delta-like-expressing AFT024 feeder cells revealed increased amounts of sternness-related protein...
- Host-Derived MCP-1 and MIP-1 alpha Regulate Protective Anti-Tumor Immunity to Localized and Metastatic B16 Melanoma
[作者：Nakasone, Y; Fujimoto, M; Matsushita, T; Hamaguchi, Y; Huu, DL; Yanaba, M; Sato, S; Takehara, K; Hasegawa, M,期刊：American Journal of Pathology, 页码：365-374 , 文章类型： Article，,卷期：2012年180-1]
- Leukocytic infiltration into malignant melanoma lesions is tightly regulated by chemokines. To assess the role of the CC chemokines monocyte chemotactic protein-1 (MCP-1/chemokine ligand 2) and macrophage inflammatory pr...
- Alterations in Nuclear Pore Architecture Allow Cancer Cell Entry into or Exit from Drug-Resistant Dormancy
[作者：Kinoshita, Y; Kalir, T; Rahaman, J; Dottino, P; Kohtz, DS,期刊：American Journal of Pathology, 页码：375-389 , 文章类型： Article，,卷期：2012年180-1]
- Phenotypic diversity arises in tumors just as it does in developing organisms, and tumor recurrence frequently manifests from the selective survival of divergent drug-resistant cells. Although the expanding tumor cell po...
- Tumor Cell Cross Talk with Tumor-Associated Leukocytes Leads to Induction of Tumor Exosomal Fibronectin and Promotes Tumor Progression
[作者：Deng, ZB; Cheng, ZQ; Xiang, XY; Yan, J; Zhuang, XY; Liu, CR; Jiang, H; Ju, SW; Zhang, LF; Grizzle, W; Mobley, J; Roman, J; Miller, D; Zhang, HG,期刊：American Journal of Pathology, 页码：390-398 , 文章类型： Article，,卷期：2012年180-1]
- Exosomes participate in intercellular communication, but most data published are based on exosomes released from in vitro cultured cells that do not communicate with neighboring cells located in the same inicroenvironmen...
- Apelin Is Required for Non-Neovascular Remodeling in the Retina
[作者：McKenzie, JAG; Fruttiger, M; Abraham, S; Lange, CAK; Stone, J; Gandhi, P; Wang, XM; Bainbridge, J; Moss, SE; Greenwood, J,期刊：American Journal of Pathology, 页码：399-409 , 文章类型： Article，,卷期：2012年180-1]
- Retinal pathologies are frequently accompanied by retinal vascular responses, including the formation of new vessels by angiogenesis (neovascularization). Pathological vascular changes may also include less well characte...
- Chronic Inhibition of Epidermal Growth Factor Receptor Tyrosine Kinase and Extracellular Signal-Regulated Kinases 1 and 2 (ERK1/2) Augments Vascular Response to Limb Ischemia in Type 2 Diabetic Mice
[作者：Choi, SK; Galan, M; Partyka, M; Trebak, M; Belmadani, S; Matrougui, K,期刊：American Journal of Pathology, 页码：410-418 , 文章类型： Article，,卷期：2012年180-1]
- Type 2 diabetes is a key risk factor for ischemia-dependent pathology; therefore, a significant medical need exists to develop novel therapies that increase the formation of new vessels. We explored the therapeutic poten...
- Impaired ATP-Induced Coronary Blood Flow and Diminished Aortic NTPDase Activity Precede Lesion Formation in Apolipoprotein E-Deficient Mice
[作者：Mercier, N; Kiviniemi, TO; Saraste, A; Miiluniemi, M; Silvola, J; Jalkanen, S; Yegutkin, GG,期刊：American Journal of Pathology, 页码：419-428 , 文章类型： Article，,卷期：2012年180-1]
- Intravascular ATP and ADP are important regulators of vascular tone, thrombosis, inflammation, and angiogenesis. This study was undertaken to evaluate the contribution of purinergic signaling to disturbed vasodilation an...
- The Pulmonary Mesenchymal Tissue Layer Is Defective in an in Vitro Recombinant Model of Nitrofen-Induced Lung Hypoplasia
[作者：van Loenhout, RB; Tseu, I; Fox, EK; Huang, Z; Tibboel, D; Post, M; Keijzer, R,期刊：American Journal of Pathology, 页码：48-60 , 文章类型： Article，,卷期：2012年180-1]
- Despite modern treatments, congenital diaphragmatic hernia (CDH) remains associated with variable survival and significant morbidity. The associated pulmonary hypoplasia is a major determinant of outcome. To develop bett...
- Elastase/LPS-Exposed Mice Exhibit Impaired Innate Immune Responses to Bacterial Challenge Role of Scavenger Receptor A
[作者：Ganesan, S; Faris, AN; Comstock, AT; Sonstein, J; Curtis, JL; Sajjan, US,期刊：American Journal of Pathology, 页码：61-72 , 文章类型： Article，,卷期：2012年180-1]
- Nontypeable Haemophilus influenzae (NTHi) is an important bacterial pathogen associated with lower respiratory tract colonization and with acute exacerbations and disease progression in chronic obstructive pulmonary dise...
- Chronic Inflammatory Cardiomyopathy of Interferon gamma-Overexpressing Transgenic Mice Is Mediated by Tumor Necrosis Factor-alpha
[作者：Torzewski, M; Wenzel, P; Kleinert, H; Becker, C; El-Masri, J; Wiese, E; Brandt, M; Pautz, A; Twardowski, L; Schmitt, E; Munzel, T; Reifenberg, K,期刊：American Journal of Pathology, 页码：73-81 , 文章类型： Article，,卷期：2012年180-1]
- We recently described a model of inflammatory cardiomyopathy in interferon (IFN)-gamma overexpressing transgenic mice stably circulating IFN-gamma in the serum referred to as SAP IFN-gamma mice. SAP-IFN-gamma transgenic ...
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