- Co-Regulation of Transcellular and Paracellular Leak Across Microvascular Endothelium by Dynamin and Rac
[作者：Armstrong, SM; Khajoee, V; Wang, CS; Wang, TL; Tigdi, J; Yin, J; Kuebler, WM; Gillrie, M; Davis, SP; Ho, M; Lee, WL,期刊：American Journal of Pathology, 页码：1308-1323 , 文章类型： Article，,卷期：2012年180-3]
- Increased permeability of the microvascular endothelium to fluids and proteins is the hallmark of inflammatory conditions such as sepsis. Leakage can occur between (paracellular) or through (transcytosis) endothelial cel...
- Host-Derived TGFB1 Deficiency Suppresses Lesion Development in a Mouse Model of Endometriosis
[作者：Hull, ML; Johan, MZ; Hodge, WL; Robertson, SA; Ingman, WV,期刊：American Journal of Pathology, 页码：880-887 , 文章类型： Article，,卷期：2012年180-3]
- Transforming growth factor-beta 1 (TGFB1) is a multi-functional cytokine that is abundant in both endometriotic lesions and the peritoneal fluid in women with endometriosis. However, the role of TGFB1 in the development ...
- MMP-14 Is Expressed in Preeclamptic Placentas and Mediates Release of Soluble Endoglin
[作者：Kaitu'u-Lino, TJ; Palmer, KR; Whitehead, CL; Williams, E; Lappas, M; Tong, S,期刊：American Journal of Pathology, 页码：888-894 , 文章类型： Article，,卷期：2012年180-3]
- Soluble endoglin is an anti-angiogenic protein that is released from the placenta and contributes to both maternal endothelial dysfunction and the clinical features of severe preeclampsia. The mechanism through which sol...
- Integrative Molecular Profiling Reveals Asparagine Synthetase Is a Target in Castration-Resistant Prostate Cancer
[作者：Sircar, K; Huang, H; Hu, LM; Cogdell, D; Dhillon, J; Tzelepi, V; Efstathiou, E; Koumakpayi, IH; Saad, F; Luo, DJ; Bismar, TA; Aparicio, A; Troncoso, P; Navone, N; Zhang, W,期刊：American Journal of Pathology, 页码：895-903 , 文章类型： Article，,卷期：2012年180-3]
- The identification of new and effective therapeutic targets for the lethal, castration-resistant stage of prostate cancer (CRPC) has been challenging because of both the paucity of adequate frozen tissues and a lack of i...
- TFF3 Is a Normal Breast Epithelial Protein and Is Associated with Differentiated Phenotype in Early Breast Cancer but Predisposes to Invasion and Metastasis in Advanced Disease
[作者：Ahmed, ARH; Griffiths, AB; Tilby, MT; Westley, BR; May, FEB,期刊：American Journal of Pathology, 页码：904-916 , 文章类型： Article，,卷期：2012年180-3]
- The trefoil protein TFF3 stimulates invasion and angiogenesis in vitro. To determine whether it has a role in breast tumor metastasis and angiogencsis, its levels were measured by immunohistochemistry in breast tissue wi...
- Low-Level Expression of miR-375 Correlates with Poor Outcome and Metastasis While Altering the Invasive Properties of Head and Neck Squamous Cell Carcinomas
[作者：Harris, T; Jimenez, L; Kawachi, N; Fan, JB; Chen, J; Belbin, T; Ramnauth, A; Loudig, O; Keller, CE; Smith, R; Prystowsky, MB; Schlecht, NF; Segall, JE; Childs, G,期刊：American Journal of Pathology, 页码：917-928 , 文章类型： Article，,卷期：2012年180-3]
- Small, noncoding microRNAs (miRNAs) have been shown to be abnormally expressed in every tumor type examined. We used comparisons of global miRNA expression profiles of head and neck squamous cell carcinoma (HNSCC) sample...
- The NF-kappa B Subunit c-Rel Stimulates Cardiac Hypertrophy and Fibrosis
[作者：Gaspar-Pereira, S; Fullard, N; Townsend, PA; Banks, PS; Ellis, EL; Fox, C; Maxwell, AG; Murphy, LB; Kirk, A; Bauer, R; Caamano, JH; Figg, N; Foo, RS; Mann, J; Mann, DA; Oakley, F,期刊：American Journal of Pathology, 页码：929-939 , 文章类型： Article，,卷期：2012年180-3]
- Cardiac remodeling and hypertrophy are the pathological consequences of cardiovascular disease and are correlated with its associated mortality. Activity of the transcription factor NF-kappa B is increased in the disease...
- Adenovirus-Mediated Gene Transfer of TGF-beta 1 to the Renal Glomeruli Leads to Proteinuria
[作者：Ghayur, A; Liu, LM; Kolb, M; Chawla, A; Lambe, S; Kapoor, A; Margetts, PJ,期刊：American Journal of Pathology, 页码：940-951 , 文章类型： Article，,卷期：2012年180-3]
- The mechanism of proteinuria in many common kidney diseases involves glomerular hemodynamic effects and local expression of angiogenic, fibrogenic, and vasoactive factors. Transforming growth factor (TGF)-beta has been a...
- beta 1 Integrin Gene Excision in the Adult Murine Cardiac Myocyte Causes Defective Mechanical and Signaling Responses
[作者：Li, RX; Wu, Y; Manso, AM; Gu, YS; Liao, P; Israeli, S; Yajima, T; Nguyen, U; Huang, MS; Dalton, ND; Peterson, KL; Ross, RS,期刊：American Journal of Pathology, 页码：952-962 , 文章类型： Article，,卷期：2012年180-3]
- How mechanical signals are transmitted in the cardiac myocyte is poorly understood. In this study, we produced a tamoxifen-inducible mouse model in which beta 1 integrin could be reduced specifically in the adult cardiom...
- Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities
[作者：Tomaru, U; Takahashi, S; Ishizu, A; Miyatake, Y; Gohda, A; Suzuki, S; Ono, A; Ohara, J; Baba, T; Murata, S; Tanaka, K; Kasahara, M,期刊：American Journal of Pathology, 页码：963-972 , 文章类型： Article，,卷期：2012年180-3]
- The proteasome is a multicatalytic enzyme complex responsible for the degradation of both normal and damaged proteins. An age-related decline in proteasomal activity has been implicated in various age-related pathologies...
- Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence
[作者：Chen, J; Xavier, S; Moskowitz-Kassai, E; Chen, R; Lu, CY; Sanduski, K; Spes, A; Turk, B; Goligorsky, MS,期刊：American Journal of Pathology, 页码：973-983 , 文章类型： Article，,卷期：2012年180-3]
- Stress-induced premature senescence (SIPS) of endothelial cells (ECs) has emerged as a contributor to global EC dysfunction. One of the cellular abnormalities mechanistically linked to SIPS is lysosomal dysfunction. ha t...
- Epithelial Expression of the Cytosolic Retinoid Chaperone Cellular Retinol Binding Protein II Is Essential for in Vivo Imprinting of Local Gut Dendritic Cells by Lumenal Retinoids
[作者：McDonald, KG; Leach, MR; Brooke, KWM; Wang, CH; Wheeler, LW; Hanly, EK; Rowley, CW; Levin, MS; Wagner, M; Li, E; Newberry, RD,期刊：American Journal of Pathology, 页码：984-997 , 文章类型： Article，,卷期：2012年180-3]
- Dendritic cells (DCs) use all-trans retinoic acid (ATRA) to promote characteristic intestinal responses, including Foxp3(+) Treg conversion, lymphocyte gut homing molecule expression, and IgA production. How this ability...
- Chronic Alcohol Exposure Stimulates Adipose Tissue Lipolysis in Mice
[作者：Zhong, W; Zhao, YT; Tang, YA; Wei, XL; Shi, X; Sun, WL; Sun, XH; Yin, XM; Sun, XG; Kim, S; McClain, CJ; Zhang, X; Zhou, ZX,期刊：American Journal of Pathology, 页码：998-1007 , 文章类型： Article，,卷期：2012年180-3]
- Alcohol consumption induces liver steatosis; therefore, this study investigated the possible role of adipose tissue dysfunction in the pathogenesis of alcoholic steatosis. Mice were pair-fed an alcohol or control liquid ...
- Collagen VI Ablation Retards Brain Tumor Progression Due to Deficits in Assembly of the Vascular Basal Lamina
[作者：You, WK; Bonaldo, P; Stallcup, WB,期刊：American Journal of Pathology, 页码：1145-1158 , 文章类型： Article，,卷期：2012年180-3]
- To investigate the importance of the vascular basal lamina in tumor blood vessel morphogenesis and function, we compared vessel development, vessel function, and progression of B16F10 melanoma tumors in the brains of wil...
- ALDH1-Bright Epithelial Ovarian Cancer Cells Are Associated with CD44 Expression, Drug Resistance, and Poor Clinical Outcome
[作者：Wang, YC; Yo, YT; Lee, HY; Liao, YP; Chao, TK; Su, PH; Lai, HC,期刊：American Journal of Pathology, 页码：1159-1169 , 文章类型： Article，,卷期：2012年180-3]
- The role of aldehyde dehydrogenase 1 (ALDH1) as an ovarian cancer stem cell marker and its clinical significance have rarely been explored. We used an Al-defluor assay to isolate ALDER-bright (ALDH1(br)) cells from epith...
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