- GABA(B) Receptor-Positive Modulators: Brain Region-Dependent Effects
[作者:Hensler, JG; Advani, T; Burke, TF; Cheng, K; Rice, KC; Koek, W,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:19-26 , 文章类型: Article,,卷期:2012年340-1]
- This study examined the positive modulatory properties of 2,6-di-tert- butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and (R, S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3-Hbenzofuran-2-one (rac-BHFF) at g...
- Beneficial Effects of PKF275-055, a Novel, Selective, Orally Bioavailable, Long-Acting Dipeptidyl Peptidase IV Inhibitor in Streptozotocin-Induced Diabetic Peripheral Neuropathy
[作者:Bianchi, R; Cervellini, I; Porretta-Serapiglia, C; Oggioni, N; Burkey, B; Ghezzi, P; Cavaletti, G; Lauria, G,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:64-72 , 文章类型: Article,,卷期:2012年340-1]
- 1-[(2-adamantyl)amino]acetyl-2-cyano-(S)-pyrrolidine, monohydrochloride (PKF275-055), a vildagliptin analog, is a novel, selective, potent, orally bioavailable, and long-acting dipeptidyl peptidase IV inhibitor. We studi...
- Effects of Repeated 3,4-Methylenedioxymethamphetamine Administration on Neurotransmitter Efflux and Sensory-Evoked Discharge in the Ventral Posterior Medial Thalamus
[作者:Starr, MA; Page, ME; Waterhouse, BD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:73-82 , 文章类型: Article,,卷期:2012年340-1]
- 3,4-Methylenedioxymethamphetamine (MDMA) is known to enhance tactile sensory perception, an effect that contributes to its popularity as a recreational drug. The neurophysiological basis for the effects of MDMA on somato...
- The Fate of Bacterial Cocaine Esterase (CocE): An In Vivo Study of CocE-Mediated Cocaine Hydrolysis, CocE Pharmacokinetics, and CocE Elimination
[作者:Brim, RL; Noon, KR; Collins, GT; Stein, A; Nichols, J; Narasimhan, D; Ko, MC; Woods, JH; Sunahara, RK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:83-95 , 文章类型: Article,,卷期:2012年340-1]
- Cocaine abuse and toxicity remain widespread problems in the United States. Currently cocaine toxicity is treated only symptomatically, because there is no Food and Drug Administration-approved pharmacotherapy for this i...
- Synergistic Self-Administration of Ethanol and Cocaine Directly into the Posterior Ventral Tegmental Area: Involvement of Serotonin-3 Receptors
[作者:Ding, ZM; Oster, SM; Hauser, SR; Toalston, JE; Bell, RL; McBride, WJ; Rodd, ZA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:202-209 , 文章类型: Article,,卷期:2012年340-1]
- Ethanol (EtOH) and cocaine are both self-administered into the posterior ventral tegmental area (VTA). Self-administration of either drug is prevented by coadministration of a serotonin (5-HT(3)) receptor antagonist. Ele...
- Protection from Myocardial Ischemia/Reperfusion Injury by a Positive Allosteric Modulator of the A(3) Adenosine Receptor
[作者:Du, LL; Gao, ZG; Nithipatikom, K; IJzerman, AP; van Veldhoven, JPD; Jacobson, KA; Gross, GJ; Auchampach, JA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:210-217 , 文章类型: Article,,卷期:2012年340-1]
- Adenosine is increased in ischemic tissues where it serves a protective role by activating adenosine receptors (ARs), including the A(3) AR subtype. We investigated the effect of N-{2-[(3,4-dichlorophenyl)amino] quinolin...
- Hemokinin-1 Stimulates Prostaglandin E(2) Production in Human Colon through Activation of Cyclooxygenase-2 and Inhibition of 15-Hydroxyprostaglandin Dehydrogenase
[作者:Dai, LY; Perera, DS; King, DW; Southwell, BR; Burcher, E; Liu, L,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:27-36 , 文章类型: Article,,卷期:2012年340-1]
- Hemokinin-1 (HK-1) is a newly identified tachykinin, originating from the immune system rather than neurons, and may participate in the immune and inflammatory response. In colonic mucosa of patients with inflammatory bo...
- Expression of ATP-Binding Cassette Membrane Transporters in Rodent and Human Sertoli Cells: Relevance to the Permeability of Antiretroviral Therapy at the Blood-Testis Barrier
[作者:Robillard, KR; Hoque, MT; Bendayan, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:96-108 , 文章类型: Article,,卷期:2012年340-1]
- The blood-testis barrier (BTB), composed primarily of Sertoli cells, is responsible for protecting developing germ cells from xenobiotic exposure. ATP-binding cassette (ABC) membrane-associated drug efflux transporters, ...
- Arthritic Joint-Targeting Small Interfering RNA-Encapsulated Liposome: Implication for Treatment Strategy for Rheumatoid Arthritis
[作者:Komano, Y; Yagi, N; Onoue, I; Kaneko, K; Miyasaka, N; Nanki, T,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:109-113 , 文章类型: Article,,卷期:2012年340-1]
- RNA interference, mediated by small interfering RNA (siRNA), is effective in silencing genes with a high degree of specificity. To explore the therapeutic potential of systemically administered siRNA for rheumatoid arthr...
- Pharmacological Activation of Small Conductance Calcium-Activated Potassium Channels with Naphtho[1,2-d]thiazol-2-ylamine Decreases Guinea Pig Detrusor Smooth Muscle Excitability and Contractility
[作者:Parajuli, SP; Soder, RP; Hristov, KL; Petkov, GV,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:114-123 , 文章类型: Article,,卷期:2012年340-1]
- Small conductance Ca(2+)-activated K(+) (SK) and intermediate conductance Ca(2+)-activated K(+) (IK) channels are thought to be involved in detrusor smooth muscle (DSM) excitability and contractility. Using naphtho[1,2-d...
- CEP-26401 (Irdabisant), a Potent and Selective Histamine H(3) Receptor Antagonist/Inverse Agonist with Cognition-Enhancing and Wake-Promoting Activities
[作者:Raddatz, R; Hudkins, RL; Mathiasen, JR; Gruner, JA; Flood, DG; Aimone, LD; Le, SY; Schaffhauser, H; Duzic, E; Gasior, M; Bozyczko-Coyne, D; Marino, MJ; Ator, MA; Bacon, ER; Mallamo, JP; Williams, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:124-133 , 文章类型: Article,,卷期:2012年340-1]
- CEP-26401 [irdabisant; 6-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2H-pyridazin-3-one HCl] is a novel, potent histamine H(3) receptor (H(3)R) antagonist/inverse agonist with drug-like properties. High affinit...
- Acetaminophen-Induced Hepatotoxicity and Protein Nitration in Neuronal Nitric-Oxide Synthase Knockout Mice
[作者:Agarwal, R; Hennings, L; Rafferty, TM; Letzig, LG; McCullough, S; James, LP; MacMillan-Crow, LA; Hinson, JA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:134-142 , 文章类型: Article,,卷期:2012年340-1]
- In overdose acetaminophen (APAP) is hepatotoxic. Toxicity occurs by metabolism to N-acetyl-p-benzoquinone imine, which depletes GSH and covalently binds to proteins followed by protein nitration. Nitration can occur via ...
- Adenylate Cyclase/cAMP/Protein Kinase A Signaling Pathway Inhibits Endothelin Type A Receptor-Operated Ca(2+) Entry Mediated via Transient Receptor Potential Canonical 6 Channels
[作者:Horinouchi, T; Higa, T; Aoyagi, H; Nishiya, T; Terada, K; Miwa, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:143-151 , 文章类型: Article,,卷期:2012年340-1]
- Receptor-operated Ca(2+) entry (ROCE) via transient receptor potential canonical channel 6 (TRPC6) is important machinery for an increase in intracellular Ca(2+) concentration triggered by the activation of G(q) protein-...
- Small Molecule Positive Allosteric Modulation of TRPV1 Activation by Vanilloids and Acidic pH
[作者:Kaszas, K; Keller, JM; Coddou, C; Mishra, SK; Hoon, MA; Stojilkovic, S; Jacobson, KA; Iadarola, MJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:152-160 , 文章类型: Article,,卷期:2012年340-1]
- Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a high-conductance, nonselective cation channel strongly expressed in nociceptive primary afferent neurons of the peripheral nervous system and ...
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