- Formation of raloxifene homo-dimer in CYP3A4, evidence for multi-substrate binding in a single catalytically competent P450 active site
[作者:Davis, JA; Greene, RJ; Han, S; Rock, DA; Wienkers, LC,期刊:Archives of Biochemistry and Biophysics , 页码:110-118 , 文章类型: Article,,卷期:2011年513-2]
- Raloxifene is a polyaromatic compound which has been reported to form radicals when incubated with horseradish peroxidase resulting in formation of a homo-dimer product. Polyaromatic phenols have also been reported to un...
- Stoichiometry and thermodynamics of the interaction between the C-terminus of human 90 kDa heat shock protein Hsp90 and the mitochondrial translocase of outer membrane Tom70
[作者:Gava, LM; Goncalves, DC; Borges, JC; Ramos, CHI,期刊:Archives of Biochemistry and Biophysics , 页码:119-125 , 文章类型: Article,,卷期:2011年513-2]
- A large majority of the 1000-1500 proteins in the mitochondria are encoded by the nuclear genome, and therefore, they are translated in the cytosol in the form and contain signals to enable the import of proteins into th...
- Guanine-induced inhibition of renal Na(+)-ATPase activity: Evidence for the involvement of the Gi protein-coupled receptor
[作者:Wengert, M; Adao-Novaes, J; Leao-Ferreira, LR; Caruso-Neves, C,期刊:Archives of Biochemistry and Biophysics , 页码:126-130 , 文章类型: Article,,卷期:2011年513-2]
- There is some evidence to show a possible role of guanosine in the modulation of cellular function, in particular, in the neuronal system. However, nothing is known about the role of guanine in renal function. The aim of...
- EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2
[作者:Chandrashekaran, IR; Adda, CG; MacRaild, CA; Anders, RF; Norton, RS,期刊:Archives of Biochemistry and Biophysics , 页码:153-157 , 文章类型: Article,,卷期:2011年513-2]
- Merozoite surface protein 2 (MSP2), one of the most abundant proteins on the surface of Plasmodium falciparum merozoites, is a promising malaria vaccine candidate. MSP2 is intrinsically unstructured and forms amyloid-lik...
- The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH
[作者:Bobyk, KD; Kim, SG; Kumar, VP; Kim, SK; West, AH; Cook, PF,期刊:Archives of Biochemistry and Biophysics , 页码:71-80 , 文章类型: Article,,卷期:2011年513-2]
- Saccharopine dehydrogenase catalyzes the NAD-dependent conversion of saccharopine to generate L-lysine and alpha-ketoglutarate. A disulfide bond between cysteine 205 and cysteine 249, in the vicinity of the dinucleotide-...
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