- The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1
[作者:Lai, YL; Song, MH; Hakala, K; Weintraub, ST; Shiio, Y,期刊:Archives of Biochemistry and Biophysics , 页码:103-110 , 文章类型: Article,,卷期:2012年518-2]
- Inactivation of the von Hippel-Lindau (VHL) tumor suppressor is associated with renal carcinoma, hemangioblastoma and pheochromocytoma. The VHL protein is a component of a ubiquitin ligase complex that ubiquitinates and ...
- Binding to retinoblastoma pocket domain does not alter the inter-domain flexibility of the J domain of SV40 large T antigen
[作者:Williams, CK; Vaithiyalingam, S; Hammel, M; Pipas, J; Chazin, WJ,期刊:Archives of Biochemistry and Biophysics , 页码:111-118 , 文章类型: Article,,卷期:2012年518-2]
- Simian Virus 40 uses the large T antigen (Tag) to bind and inactivate retinoblastoma tumor suppressor proteins (Rb), which can result in cellular transformation. Tag is a modular protein with four domains connected by fl...
- Conditioned media from lung cancer cell line A549 and PC9 inactivate pulmonary fibroblasts by regulating protein phosphorylation
[作者:Park, AM; Hayakawa, S; Honda, E; Mine, Y; Yoshida, K; Munakata, H,期刊:Archives of Biochemistry and Biophysics , 页码:133-141 , 文章类型: Article,,卷期:2012年518-2]
- Pulmonary fibrosis is a devastating condition resulting from excess extracellular matrix deposition that leads to progressive lung destruction and scarring. In the pathogenesis of fibrotic diseases, activation of myofibr...
- Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA
[作者:Loft, S; Danielsen, P; Lohr, M; Jantzen, K; Hemmingsen, JG; Roursgaard, M; Karotki, DG; Moller, P,期刊:Archives of Biochemistry and Biophysics , 页码:142-150 , 文章类型: Review,,卷期:2012年518-2]
- Oxidatively damaged DNA may be important in carcinogenesis. 8-0xo-7,8-dihydroguanine (8-oxoGua) is an abundant and mutagenic lesion excised by oxoguanine DNA glycosylase 1 (OGG1) and measurable in urine or plasma by chro...
- Cancer cell detection in tissue sections using AFM
[作者:Lekka, M; Gil, D; Pogoda, K; Dulinska-Litewka, J; Jach, R; Gostek, J; Klymenko, O; Prauzner-Bechcicki, S; Stachura, Z; Wiltowska-Zuber, J; Okon, K; Laidler, P,期刊:Archives of Biochemistry and Biophysics , 页码:151-156 , 文章类型: Article,,卷期:2012年518-2]
- Currently, cancer diagnosis relies mostly on morphological examination of exfoliated, aspirated cells or surgically removed tissue. As long as standard diagnosis is concerned, this classical approach seems to be satisfac...
- Role of connexin 43 in the mechanism of action of alendronate: Dissociation of anti-apoptotic and proliferative signaling pathways
[作者:Lezcano, V; Bellido, T; Plotkin, LI; Boland, R; Morelli, S,期刊:Archives of Biochemistry and Biophysics , 页码:95-102 , 文章类型: Article,,卷期:2012年518-2]
- Bisphosphonates (Bps) inhibit osteocyte and osteoblast apoptosis via opening of connexin (Cx) 43 hemichannels and activating the extracellular signal regulated kinases ERKs. Previously, we hypothesized that intracellular...
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