- Identification of Grass-specific Enzyme That Acylates Monolignols with p-Coumarate
[作者:Withers, S; Lu, FC; Kim, H; Zhu, YM; Ralph, J; Wilkerson, CG,期刊:Journal of Biological Chemistry, 页码:8347-8355 , 文章类型: Article,,卷期:2012年287-11]
- Lignin is a major component of plant cell walls that is essential to their function. However, the strong bonds that bind the various subunits of lignin, and its cross-linking with other plant cell wall polymers, make it ...
- Enhancers Located in Heavy Chain Regulatory Region (hs3a, hs1,2, hs3b, and hs4) Are Dispensable for Diversity of VDJ Recombination
[作者:Rouaud, P; Vincent-Fabert, C; Fiancette, R; Cogne, M; Pinaud, E; Denizot, Y,期刊:Journal of Biological Chemistry, 页码:8356-8360 , 文章类型: Article,,卷期:2012年287-11]
- V(D)J recombination occurs during the antigen-independent early steps of B-cell ontogeny. Multiple IgH cis-regulatory elements control B-cell ontogeny. IGCR1 (intergenic control region 1), the DQ52 promoter/enhancer, and...
- Crystal Structure of Hyperthermophilic Endo-beta-1,4-glucanase IMPLICATIONS FOR CATALYTIC MECHANISM AND THERMOSTABILITY
[作者:Zheng, BS; Yang, W; Zhao, XY; Wang, YG; Lou, ZY; Rao, ZH; Feng, Y,期刊:Journal of Biological Chemistry, 页码:8336-8346 , 文章类型: Article,,卷期:2012年287-11]
- Endo-beta-1,4-glucanase from thermophilic Fervidobacterium nodosum Rt17-B1 (FnCel5A), a new member of glycosyl hydrolase family 5, is highly thermostable and exhibits the highest activity on carboxymethylcellulose among ...
- C-terminal Mutations Destabilize SIL1/BAP and Can Cause Marinesco-Sjogren Syndrome
[作者:Howes, J; Shimizu, Y; Feige, MJ; Hendershot, LM,期刊:Journal of Biological Chemistry, 页码:8552-8560 , 文章类型: Article,,卷期:2012年287-11]
- Marinesco-Sjogren syndrome (MSS) is an autosomal recessive, neurodegenerative, multisystem disorder characterized by severe phenotypes developing in infancy. Recently, mutations in the endoplasmic reticulum (ER)-associat...
- The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP
[作者:Niwa, H; Ewens, CA; Tsang, C; Yeung, HO; Zhang, XD; Freemont, PS,期刊:Journal of Biological Chemistry, 页码:8561-8570 , 文章类型: Article,,卷期:2012年287-11]
- p97/valosin-containing protein (VCP) is a type II ATPase associated with various cellular activities that forms a homohexamer with each protomer containing an N-terminal domain (N-domain); two ATPase domains, D1 and D2; ...
- Recognition of Human Tumor Necrosis Factor alpha (TNF-alpha) by Therapeutic Antibody Fragment ENERGETICS AND STRUCTURAL FEATURES
[作者:Marusic, J; Podlipnik, C; Jevsevar, S; Kuzman, D; Vesnaver, G; Lah, J,期刊:Journal of Biological Chemistry, 页码:8613-8620 , 文章类型: Article,,卷期:2012年287-11]
- Human tumor necrosis factor alpha (TNF-alpha) exists in its functional state as a homotrimeric protein and is involved in inflammation processes and immune response of a human organism. Overproduction of TNF-alpha result...
- Structure-Activity Analysis of the Dermcidin-derived Peptide DCD-1L, an Anionic Antimicrobial Peptide Present in Human Sweat
[作者:Paulmann, M; Arnold, T; Linke, D; Ozdirekcan, S; Kopp, A; Gutsmann, T; Kalbacher, H; Wanke, I; Schuenemann, VJ; Habeck, M; Burck, J; Ulrich, AS; Schittek, B,期刊:Journal of Biological Chemistry, 页码:8434-8443 , 文章类型: Article,,卷期:2012年287-11]
- Dermcidin encodes the anionic amphiphilic peptide DCD-1L, which displays a broad spectrum of antimicrobial activity under conditions resembling those in human sweat. Here, we have investigated its mode of antimicrobial a...
- Angiopoietin-like 4 (Angptl4) Protein Is a Physiological Mediator of Intracellular Lipolysis in Murine Adipocytes
[作者:Gray, NE; Lam, LN; Yang, KR; Zhou, AY; Koliwad, S; Wang, JC,期刊:Journal of Biological Chemistry, 页码:8444-8456 , 文章类型: Article,,卷期:2012年287-11]
- Intracellular triacylglycerol (TG) hydrolysis and fatty acid release by the white adipose tissue (WAT) during a fast is stimulated by counter-regulatory factors acting in concert, although how adipocytes integrate these ...
- Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces beta-Secretase (BACE1) Levels and A beta Generation
[作者:Ding, Y; Ko, MH; Pehar, M; Kotch, F; Peters, NR; Luo, Y; Salamat, SM; Puglielli, L,期刊:Journal of Biological Chemistry, 页码:8424-8433 , 文章类型: Article,,卷期:2012年287-11]
- The cellular levels of beta-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer disease (AD) amyloid beta-peptide (A beta), are tightly regulated by two ER-based acetyl-CoA:ly...
- Impaired Transforming Growth Factor-beta (TGF-beta) Transcriptional Activity and Cell Proliferation Control of a Menin In-frame Deletion Mutant Associated with Multiple Endocrine Neoplasia Type 1 (MEN1)
[作者:Canaff, L; Vanbellinghen, JF; Kaji, H; Goltzman, D; Hendy, GN,期刊:Journal of Biological Chemistry, 页码:8584-8597 , 文章类型: Article,,卷期:2012年287-11]
- Multiple endocrine neoplasia type 1 (MEN1) is characterized by tumors of the parathyroid, enteropancreas, and anterior pituitary. The MEN1 gene encodes the tumor suppressor menin of 610 amino acids that has multiple prot...
- Structural and Biochemical Basis of Yos9 Protein Dimerization and Possible Contribution to Self-association of 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Degradation Ubiquitin-Ligase Complex
[作者:Hanna, J; Schutz, A; Zimmermann, F; Behlke, J; Sommer, T; Heinemann, U,期刊:Journal of Biological Chemistry, 页码:8633-8640 , 文章类型: Article,,卷期:2012年287-11]
- In yeast, the membrane-bound HMG-CoA reductase degradation (HRD) ubiquitin-ligase complex is a key player of the ER-associated protein degradation pathway that targets misfolded proteins for proteolysis. Yos9, a componen...
- Phosphorylation of Amyloid-beta Peptide at Serine 8 Attenuates Its Clearance via Insulin-degrading and Angiotensin-converting Enzymes
[作者:Kumar, S; Singh, S; Hinze, D; Josten, M; Sahl, HG; Siepmann, M; Walter, J,期刊:Journal of Biological Chemistry, 页码:8641-8651 , 文章类型: Article,,卷期:2012年287-11]
- Background: Amyloid-beta peptide (A beta) is degraded by different proteases. We recently demonstrated phosphorylation of A beta. Results: Phosphorylation of A beta decreases its clearance by microglial BV-2 cells and se...
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