- HIF-Prolyl Hydroxylases in the Rat Kidney Physiologic Expression Patterns and Regulation in Acute Kidney Injury
[作者：Schodel, J; Klanke, B; Weidemann, A; Buchholz, B; Bernhardt, W; Bertog, M; Amann, K; Korbmacher, C; Wiesener, M; Warnecke, C; Kurtz, A; Eckardt, KU; Willam, C,期刊：American Journal of Pathology, 页码：1663-1674 , 文章类型： Article，,卷期：2009年174-5]
- Hypoxia-inducible transcription factors (HIFs) play important roles in the response of the kidney to systemic and regional hypoxia. Degradation of HIFs is mediated by three oxygen-dependent HIF-prolyl hydroxylases (PHDs)...
- Genetic Podocyte Lineage Reveals Progressive Podocytopenia with Parietal Cell Hyperplasia in a Murine Model of Cellular/Collapsing Focal Segmental Glomerulosclerosis
[作者：Suzuki, T; Matsusaka, T; Nakayama, M; Asano, T; Watanabe, T; Ichikawa, I; Nagata, M,期刊：American Journal of Pathology, 页码：1675-1682 , 文章类型： Article，,卷期：2009年174-5]
- Focal segmental glomerulosclerosis (FSGS) is a progressive renal disease, and the glomerular visceral cell hyperplasia typically observed in cellular/collapsing FSGS is an important pathological factor in disease progres...
- Essential Role of Osteopontin in Smoking-Related Interstitial Lung Diseases
[作者：Prasse, A; Stahl, M; Schulz, G; Kayser, G; Wang, LQ; Ask, K; Yalcintepe, J; Kirschbaum, A; Bargagli, E; Zissel, G; Kolb, M; Muller-Quernheim, J; Weiss, JM; Renkl, AC,期刊：American Journal of Pathology, 页码：1683-1691 , 文章类型： Article，,卷期：2009年174-5]
- Smoking-related interstitial lung diseases are characterized by the accumulation of macrophages and Langerhans cells, and fibrotic remodeling, which are linked to osteopontin (OPN) expression. Therefore, OPN levels were ...
- Functional Significance and Morphological Characterization of Starvation-Induced Autophagy in the Adult Heart
[作者：Kanamori, H; Takemura, G; Maruyama, R; Goto, K; Tsujimoto, A; Ogino, A; Li, L; Kawamura, I; Takeyama, T; Kawaguchi, T; Nagashima, K; Fujiwara, T; Fujiwara, H; Seishima, M; Minatoguchi, S,期刊：American Journal of Pathology, 页码：1705-1714 , 文章类型： Article，,卷期：2009年174-5]
- To examine the functional significance and morphological characteristics of starvation-induced autophagy in the adult heart, we made green fluorescent protein-microtubule-associated protein 1-light chain 3 (LC3) transgen...
- Role of Plasmacytoid Dendritic Cells for Aberrant Class II Expression in Exocrine Glands from Estrogen-Deficient Mice of Healthy Background
[作者：Arakaki, R; Nagaoka, A; Ishimaru, N; Yamada, A; Yoshida, S; Hayashi, Y,期刊：American Journal of Pathology, 页码：1715-1724 , 文章类型： Article，,卷期：2009年174-5]
- Although it has been well documented that aberrant major histocompatibility complex class II molecules may contribute to the development of autoimmune disorders, the precise mechanisms responsible for their tissue-specif...
- CCN3 (NOV) Is a Negative Regulator of CCN2 (CTGF) and a Novel Endogenous Inhibitor of the Fibrotic Pathway in an in Vitro Model of Renal Disease
[作者：Riser, BL; Najmabadi, F; Perbal, B; Peterson, DR; Rambow, JA; Riser, ML; Sukowski, E; Yeger, H; Riser, SC,期刊：American Journal of Pathology, 页码：1725-1734 , 文章类型： Article，,卷期：2009年174-5]
- Fibrosis is a major cause of end-stage renal disease, and although initiation factors have been elucidated, uncertainty concerning the downstream pathways has hampered the development of anti-fibrotic therapies. CCN2 (CT...
- Inhibition of Prostaglandin D Synthase Suppresses Muscular Necrosis
[作者：Mohri, I; Aritake, K; Taniguchi, H; Sato, Y; Kamauchi, S; Nagata, N; Maruyama, T; Taniike, M; Urade, Y,期刊：American Journal of Pathology, 页码：1735-1744 , 文章类型： Article，,卷期：2009年174-5]
- Duchenne muscular dystrophy is a fatal muscle wasting disease that is characterized by a deficiency in the protein dystrophin. Previously, we reported that the expression of hematopoietic prostaglandin D synthase (HPGDS)...
- Notch1 Signaling in FIZZ1 Induction of Myofibroblast Differentiation
[作者：Liu, TJ; Hu, B; Choi, YY; Chung, MJ; Ullenbruch, M; Yu, HF; Lowe, JB; Phan, SH,期刊：American Journal of Pathology, 页码：1745-1755 , 文章类型： Article，,卷期：2009年174-5]
- Notch1 is an evolutionarily conserved receptor that regulates cell fate, including such events as differentiation, proliferation, and apoptosis. Myofibroblast differentiation is a key feature of lung fibrosis. Found in i...
- The Transmembrane src Substrate Trask Is an Epithelial Protein that Signals during Anchorage Deprivation
[作者：Spassov, DS; Baehner, FL; Wong, CH; McDonough, S; Moasser, MM,期刊：American Journal of Pathology, 页码：1756-1765 , 文章类型： Article，,卷期：2009年174-5]
- The roles of epithelial cells encompass both cellular- and tissue-level functions that involve numerous cell-cell and cell-matrix interactions, which ultimately mediate the highly structured arrangement of cells on a bas...
- Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice
[作者：Mitchell, C; Couton, D; Couty, JP; Anson, M; Crain, AM; Bizet, V; Renia, L; Pol, S; Mallet, V; Gilgenkrantz, H,期刊：American Journal of Pathology, 页码：1766-1775 , 文章类型： Article，,卷期：2009年174-5]
- Inflammation has been shown to induce the progression of fibrosis in response to liver injury. Among inflammatory cells, macrophages and lymphocytes play major roles in both the constitution and resolution of liver fibro...
- Reactive Oxygen Species Mediate Liver Injury Through Parenchymal Nuclear Factor-kappa B Inactivation in Prolonged Ischemia/Reperfusion
[作者：Llacuna, L; Mari, M; Lluis, JM; Garcia-Ruiz, C; Fernandez-Checa, JC; Morales, A,期刊：American Journal of Pathology, 页码：1776-1785 , 文章类型： Article，,卷期：2009年174-5]
- Nuclear factor (NF)-kappa B participates in ischemia/reperfusion (I/R) hepatic signaling, stimulating both protective mechanisms and the generation of inflammatory cytokines. After analyzing NF-kappa B activation during ...
- Positive Role of CCAAT/Enhancer-Binding Protein Homologous Protein, a Transcription Factor Involved in the Endoplasmic Reticulum Stress Response in the Development of Colitis
[作者：Namba, T; Tanaka, K; Ito, Y; Ishihara, T; Hoshino, T; Gotoh, T; Endo, M; Sato, K; Mizushima, T,期刊：American Journal of Pathology, 页码：1786-1798 , 文章类型： Article，,卷期：2009年174-5]
- Although recent reports suggest that the endoplasm ic reticulum (ER) stress response is induced in association with the development of inflammatory bowel disease, its role in the pathogenesis of inflammatory bowel diseas...
- Genetically Modified CD34(+) Hematopoietic Stem Cells Contribute to Turnover of Brain Perivascular Macrophages in Long-Term Repopulated Primates
[作者：Soulas, C; Donahue, RE; Dunbar, CE; Persons, DA; Alvarez, X; Williams, KC,期刊：American Journal of Pathology, 页码：1808-1817 , 文章类型： Article，,卷期：2009年174-5]
- Studies in rodents have shown that brain perivascular macrophages are derived from bone marrow precursors. Less is known about the origin and turnover of perivascular cells in the human central nervous system. we took ad...
- Altered Dendritic Cell Phenotype in Response to Leishmania amazonensis Amastigote Infection Is Mediated by MAP Kinase, ERK
[作者：Boggiatto, PM; Jie, F; Ghosh, M; Gibson-Corley, KN; Ramer-Tait, AE; Jones, DE; Petersen, CA,期刊：American Journal of Pathology, 页码：1818-1826 , 文章类型： Article，,卷期：2009年174-5]
- Initiation of productive immune responses against Leishmania depends on the successful transition of dendritic cells (DC) from an immature to a mature phenotype. This process is characterized by high CD40 surface express...
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