- The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38
[作者:LaBonte, MJ; Manegold, PC; Wilson, PM; Fazzone, W; Louie, SG; Lenz, HJ; Ladner, RD,期刊:International Journal of Cancer, 页码:2957-2969 , 文章类型: Article,,卷期:2009年125-12]
- Members of the human epidermal receptor (HER) family are frequently associated with aggressive disease and poor prognosis in multiple malignancies. Lapatinib is a dual tyrosine kinase inhibitor targeting the epidermal gr...
- Specific thermal ablation of tumor cells using single-walled carbon nanotubes targeted by covalently-coupled monoclonal antibodies
[作者:Marches, R; Chakravarty, P; Musselman, IH; Bajaj, P; Azad, RN; Pantano, P; Draper, RK; Vitetta, ES,期刊:International Journal of Cancer, 页码:2970-2977 , 文章类型: Article,,卷期:2009年125-12]
- CD22 is broadly expressed on human B cell lymphomas. Monoclonal anti-CD22 antibodies alone, or coupled to toxins, have been used to selectively target these tumors both in SCID mice with xenografted human lymphoma cell l...
- Systemic delivery of siRNA specific to tumor mediated by atelocollagen: Combined therapy using siRNA targeting Bcl-xL and cisplatin against prostate cancer
[作者:Mu, P; Nagahara, S; Makita, N; Tarumi, Y; Kadomatsu, K; Takei, Y,期刊:International Journal of Cancer, 页码:2978-2990 , 文章类型: Article,,卷期:2009年125-12]
- The largest obstacle to the effective use of short interfering RNA (siRNA) in an animal body is the ability to deliver it to the target tissue. Here we showed a systemic delivery method of siRNA specific to pregrown soli...
- Insulin-like growth factor 1 receptor expression in wild-type GISTs: A potential novel therapeutic target
[作者:Pantaleo, MA; Astolfi, A; Di Battista, M; Heinrich, MC; Paterini, P; Scotlandi, K; Santini, D; Catena, F; Manara, MC; Nannini, M; Maleddu, A; Saponara, M; Lolli, C; Formica, S; Biasco, G,期刊:International Journal of Cancer, 页码:2991-2994 , 文章类型: Article,,卷期:2009年125-12]
- Aberrations of the Insulin-like Growth Factor (IGF) system have been found in association with a variety of cancer types. The potential role of IGF1R has been postulated in a small subset of GISTs, but until now the impl...
- DNA methylation analysis in liquid-based cytology for cervical cancer screening
[作者:Apostolidou, S; Hadwin, R; Burnell, M; Jones, A; Baff, D; Pyndiah, N; Mould, T; Jacobs, IJ; Beddows, S; Kocjan, G; Widschwendter, M,期刊:International Journal of Cancer, 页码:2995-3002 , 文章类型: Article,,卷期:2009年125-12]
- Cervical cancer is the second most common type of cancer in women worldwide. Preinvasive disease can be detected by cervical cytology. All currently available cytology technologies rely on the visual analysis of exfoliat...
- mu-Calpain regulates caspase-dependent and apoptosis inducing factor-mediated caspase-independent apoptotic pathways in cisplatin-induced apoptosis
[作者:Liu, L; Xing, D; Chen, WR,期刊:International Journal of Cancer, 页码:2757-2766 , 文章类型: Article,,卷期:2009年125-12]
- Cisplatin, an effective anticancer agent, can induce tumor cell apoptosis via caspase-dependent and-independent pathways. However, the precise mechanism that regulates the pathways remains unclear. In this study, we show...
- Reciprocal changes in gene expression profiles of cocultured breast epithelial cells and primary fibroblasts
[作者:Rozenchan, PB; Carraro, DM; Brentani, H; Mota, LDD; Bastos, EP; Ferreira, ENE; Torre, CH; Katayama, MLH; Roela, RA; Lyra, EC; Soares, FA; Folgueira, MAAK; Goes, JCGS; Brentani, MM,期刊:International Journal of Cancer, 页码:2767-2777 , 文章类型: Article,,卷期:2009年125-12]
- The importance of epithelial-stroma interaction in normal breast development and tumor progression has been recognized. To identify genes that were regulated by these reciprocal interactions, we cocultured a nonmalignant...
- GLUT-1 expression and response to chemoradiotherapy in rectal cancer
[作者:Brophy, S; Sheehan, KM; McNamara, DA; Deasy, J; Bouchier-Hayes, DJ; Kay, EW,期刊:International Journal of Cancer, 页码:2778-2782 , 文章类型: Article,,卷期:2009年125-12]
- Preoperative chemoradiotherapy is used in locally advanced rectal cancer to reduce local recurrence and improve operability, however a proportion of tumors do not undergo significant regression. Identification of predict...
- Endogenous expression of the sodium iodide symporter mediates uptake of iodide in murine models of colorectal carcinoma
[作者:Gaertner, FC; Rohde, F; Mueller, J; Blechert, B; Janssen, KP; Essler, M,期刊:International Journal of Cancer, 页码:2783-2791 , 文章类型: Article,,卷期:2009年125-12]
- The sodium iodide symporter (NIS) mediates iodide uptake into the thyroid. Because of this mechanism, differentiated thyroid cancer is susceptible for radioiodine therapy. Functional NIS expression in extrathyroidal tumo...
- The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines
[作者:McCleese, JK; Bear, MD; Fossey, SL; Mihalek, RM; Foley, KP; Ying, WW; Barsoum, J; London, CA,期刊:International Journal of Cancer, 页码:2792-2801 , 文章类型: Article,,卷期:2009年125-12]
- Osteosarcoma (OSA), the most common malignant bone tumor in dogs and children, exhibits a similar clinical presentation and molecular biology in both species. Unfortunately, 30-40% of children and 90% of dogs still die o...
- KLF4-dependent, PPAR gamma-induced expression of GPA33 in colon cancer cell lines
[作者:Rageul, J; Mottier, S; Jarry, A; Shah, Y; Theoleyre, S; Masson, D; Gonzalez, FJ; Laboisse, CL; Denis, MG,期刊:International Journal of Cancer, 页码:2802-2809 , 文章类型: Article,,卷期:2009年125-12]
- The glycoprotein A33 (GPA33) is a colon cancer antigen. Phase I trials with I-131 and I-125 monoclonal antibody A33 in colon carcinoma patients showed excellent localization to colorectal cancer and some evidence of tumo...
- The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene
[作者:Daniel-Carmi, V; Makovitzki-Avraham, E; Reuven, EM; Goldstein, I; Zilkha, N; Rotter, V; Tzehoval, E; Eisenbach, L,期刊:International Journal of Cancer, 页码:2810-2819 , 文章类型: Article,,卷期:2009年125-12]
- The human 1-8 interferon inducible gene family consists of at least 3 functional genes; 9-27, 1-8D and 1-8U, which are all linked on an 18-kb fragment of chromosome 11 and are highly homologous. It has recently been show...
|