- HIF-1 alpha and HIF-2 alpha have divergent roles in colon cancer
[作者:Imamura, T; Kikuchi, H; Herraiz, MT; Park, DY; Mizukami, Y; Mino-Kenduson, M; Lynch, MP; Rueda, BR; Benita, Y; Xavier, RJ; Chung, DC,期刊:International Journal of Cancer, 页码:763-771 , 文章类型: Article,,卷期:2009年124-4]
- Hypoxia-inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors that mediate the cellular response to hypoxia. Their key regulatory subunits, HIF-1 alpha and HIF-2 alpha are induced similarly by hypoxi...
- Modification of HER2 pre-mRNA alternative splicing and its effects on breast cancer cells
[作者:Wan, J; Sazani, P; Kole, R,期刊:International Journal of Cancer, 页码:772-777 , 文章类型: Article,,卷期:2009年124-4]
- The oncogene HER2 is overexpressed in a variety of human tumors, providing a target for anti-cancer molecular therapies. Here, we employed a 2'-O-methoxyethyl (MOE) splice switching oligonucleotide, SSO111, to induce ski...
- Different outcome of invasive cervical cancer associated with high-risk versus intermediate-risk HPV genotype
[作者:de Cremoux, P; de la Rochefordiere, A; Savignoni, A; Kirova, Y; Alran, S; Fourchotte, V; Plancher, C; Thioux, M; Salmon, RJ; Cottu, P; Mignot, L; Sastre-Garau, X,期刊:International Journal of Cancer, 页码:778-782 , 文章类型: Article,,卷期:2009年124-4]
- Human papillomavirus (HPV) DNA sequences are associated with the large majority of invasive cervical carcinoma but the role of specific genotype(s) in the outcome of the disease is still debated. To determine the viral e...
- A novel cell-free screen identities a potent inhibitor of the Fanconi anemia pathway
[作者:Landais, I; Sobeck, A; Stone, S; LaChapelle, A; Hoatlin, ME,期刊:International Journal of Cancer, 页码:783-792 , 文章类型: Article,,卷期:2009年124-4]
- The Fanconi Anemia (FA) DNA damage response pathway is involved in the processing of DNA interstrand crosslinks (ICLs). As such, inhibition of the FA pathway could chemosensitize FA-competent tumor cells to commonly used...
- Identification of Fat4 as a candidate tumor suppressor gene in breast cancers
[作者:Qi, C; Zhu, YT; Hu, LP; Zhu, YJ,期刊:International Journal of Cancer, 页码:793-798 , 文章类型: Article,,卷期:2009年124-4]
- Fat, a candidate tumor suppressor in Drosophila, is a component of Hippo signaling pathway involved in controlling organ size. We found that a similar to 3 Mbp deletion in mouse chromosome 3 caused tumorigenesis of a non...
- EBAG9 is a tumor-promoting and prognostic factor for bladder cancer
[作者:Kumagai, J; Urano, T; Ogushi, T; Takahashi, S; Horie-Inoue, K; Fujimura, T; Azuma, K; Muramatsu, M; Ouchi, Y; Kitamura, T; Inoue, S,期刊:International Journal of Cancer, 页码:799-805 , 文章类型: Article,,卷期:2009年124-4]
- Upregulation of EBAG9 expression has been observed in several malignant tumors such as advanced breast and prostate cancers, indicating that EBAG9 may contribute to tumor proliferation. In the present study, we assess th...
- The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer
[作者:Weberpals, J; Garbuio, K; O'Brien, A; Clark-Knowles, K; Doucette, S; Antoniouk, O; Goss, G; Dimitroulakos, J,期刊:International Journal of Cancer, 页码:806-815 , 文章类型: Article,,卷期:2009年124-4]
- This study compares Breast Cancer 1 (BRCA1) anti excision repair cross complementation group 1 (ERCC1) expression as predictive markers and evaluates the in vitro enhancement of platinum sensitivity using targeted agents...
- Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility
[作者:Liao, YJ; Liu, SP; Lee, CM; Yen, CH; Chuang, PC; Chen, CY; Tsai, TF; Huang, SF; Lee, YHW; Chen, YMA,期刊:International Journal of Cancer, 页码:816-826 , 文章类型: Article,,卷期:2009年124-4]
- Hepatocellular carcinoma (HCC) is the fifth common cancer in the world and it mainly occurs in men. Glycine N-methyltransferase (GNMT) participates in one-carbon metabolism and affects DNA methylation by regulating the r...
- Causes of death among Belgian professional military radar operators: A. 37-year retrospective cohort study
[作者:Degrave, E; Meeusen, B; Grivegnee, AR; Boniol, M; Autier, P,期刊:International Journal of Cancer, 页码:945-951 , 文章类型: Article,,卷期:2009年124-4]
- Concerns have been raised about the safety of the electromagnetic (microwave) emissions of radars, as well as about the ionizing radiation that is emitted on short distances (< 2 in) by devices in the radars producing th...
- Risk of cancer in first- and second-degree relatives of testicular germ cell tumor cases and controls
[作者:Chia, VM; Li, Y; Goldin, LR; Graubard, BI; Greene, MH; Korde, L; Rubertone, MV; Erickson, RL; McGlynn, KA,期刊:International Journal of Cancer, 页码:952-957 , 文章类型: Article,,卷期:2009年124-4]
- Risk factors for testicular germ cell tumors (TGCT) have not been well identified; however, data suggest that risks of cancer in family members or men with TGCT is elevated. Using family history data from 738 cases and 9...
- Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals
[作者:Schuler, F; Dolken, L; Hirt, C; Kiefer, T; Berg, T; Fusch, G; Weitmann, K; Hoffmann, W; Fusch, C; Ianz, S; Rabkin, CS; Dolken, G,期刊:International Journal of Cancer, 页码:958-963 , 文章类型: Article,,卷期:2009年124-4]
- The t(14;18) translocation is a common genetic aberration that can be seen as an early step in pathogenesis of follicular lymphoma (FL). The significance of low level circulating t(14;18)-positive cells in healthy indivi...
- Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma
[作者:Wentzensen, N; Schiffman, M; Dunn, ST; Zuna, RE; Walker, J; Allen, RA; Zhang, R; Sherman, ME; Wacholder, S; Jeronimo, J; Gold, MA; Wang, SS,期刊:International Journal of Cancer, 页码:964-969 , 文章类型: Article,,卷期:2009年124-4]
- Diagnosis and treatment of cervical cancer precursors rely on colposcopic biopsy, which is sometimes [tampered by incorrect biopsy placement an the unclear prognostic value of poorly reproducible diagnoses such as cervic...
- Post-treatment CIN: Randomised clinical trial using hrHPV testing for prediction of residual/recurrent disease
[作者:Bais, AG; Eijkemans, MJC; Rebolj, M; Snijders, PJF; Verheijen, RHM; van Ballegooijen, M; Meijer, CJLM; Helmerhorst, TJM,期刊:International Journal of Cancer, 页码:889-895 , 文章类型: Article,,卷期:2009年124-4]
- We investigated in a randomised clinical trial whether addition (if hrHPV testing (high-risk human papillomavirus) to cytological follow-up after treatment for high-grade CIN (cervical intraepithelial neoplasia 213) can ...
- Prognostic marker profile to assess risk in stage I-III hormone receptor-positive breast cancer patients
[作者:Brerner, TM; Jacquemier, J; Charafe-Jauffret, E; Viens, P; Birnbaum, D; Linke, SP,期刊:International Journal of Cancer, 页码:896-904 , 文章类型: Article,,卷期:2009年124-4]
- Single markers are insufficient to accurately assess risk of relapse for adjuvant therapy guidance in operable breast cancer patients. In addition, (he accuracy and interpretability of current multi-marker tests is gener...
- The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae
[作者:Nakajima, T; Yamashita, S; Maekita, T; Niwa, T; Nakazawa, K; Ushijima, T,期刊:International Journal of Cancer, 页码:905-910 , 文章类型: Article,,卷期:2009年124-4]
- Aberrant DNA methylation is deeply involved in human cancers, but its inducers and targets are stili mostly unclear. Helicobacter pylori infection was recently shown to induce aberrant methylation in gastric mucosae, and...
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