- E2F1-dependent oncogenic addiction of melanoma cells to MDM2
[作者:Verhaegen, M; Checinska, A; Riblett, MB; Wang, S; Soengas, MS,期刊:Oncogene, 页码:828-841 , 文章类型: Article,,卷期:2012年31-7]
- One of the defining features of aggressive melanomas is their complexity. Hundreds of mutations and an ever increasing list of changes in the transcriptome and proteome distinguish normal from malignant melanocytic cells...
- miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTP mu
[作者:Quintavalle, C; Garofalo, M; Zanca, C; Romano, G; Iaboni, M; De Caro, MD; Martinez-Montero, JC; Incoronato, M; Nuovo, G; Croce, CM; Condorelli, G,期刊:Oncogene, 页码:858-868 , 文章类型: Article,,卷期:2012年31-7]
- Glioblastoma is the most frequent brain tumor in adults and is the most lethal form of human cancer. Despite the improvements in treatments, survival of patients remains poor. In order to identify microRNAs (miRs) involv...
- c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer
[作者:Regan, JL; Kendrick, H; Magnay, FA; Vafaizadeh, V; Groner, B; Smalley, MJ,期刊:Oncogene, 页码:869-883 , 文章类型: Article,,卷期:2012年31-7]
- BRCA1 mutation-associated breast cancer originates in oestrogen receptor-alpha-negative (ER(-)) progenitors in the mammary luminal epithelium. These cells also express high levels of the Kit gene and a recent study demon...
- The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk
[作者:Arpaia, E; Blaser, H; Quintela-Fandino, M; Duncan, G; Leong, HS; Ablack, A; Nambiar, SC; Lind, EF; Silvester, J; Fleming, CK; Rufini, A; Tusche, MW; Brustle, A; Ohashi, PS; Lewis, JD; Mak, TW,期刊:Oncogene, 页码:884-896 , 文章类型: Article,,卷期:2012年31-7]
- Proteins containing a caveolin-binding domain (CBD), such as the Rho-GTPases, can interact with caveolin-1 (Cav1) through its caveolin scaffold domain. Rho-GTPases are important regulators of p130(Cas), which is crucial ...
- Overexpression of 14-3-3 zeta in cancer cells activates PI3K via binding the p85 regulatory subunit
[作者:Neal, CL; Xu, J; Li, P; Mori, S; Yang, J; Neal, NN; Zhou, X; Wyszomierski, SL; Yu, D,期刊:Oncogene, 页码:897-906 , 文章类型: Article,,卷期:2012年31-7]
- The ubiquitously expressed 14-3-3 proteins regulate many pathways involved in transformation. Previously, we found that 14-3-3 zeta overexpression increased Akt phosphorylation in human mammary epithelial cells. Here, we...
- Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling
[作者:Pradeep, CR; Kostler, WJ; Lauriola, M; Granit, RZ; Zhang, F; Jacob-Hirsch, J; Rechavi, G; Nair, HB; Hennessy, BT; Gonzalez-Angulo, AM; Tekmal, RR; Ben-Porath, I; Mills, GB; Domany, E; Yarden, Y,期刊:Oncogene, 页码:907-917 , 文章类型: Article,,卷期:2012年31-7]
- A large fraction of ductal carcinoma in situ ( DCIS), a non-invasive precursor lesion of invasive breast cancer, overexpresses the HER2/neu oncogene. The ducts of DCIS are abnormally filled with cells that evade apoptosi...
- The proto-oncogene Pim-1 is a target of miR-33a
[作者:Thomas, M; Lange-Grunweller, K; Weirauch, U; Gutsch, D; Aigner, A; Grunweller, A; Hartmann, RK,期刊:Oncogene, 页码:918-928 , 文章类型: Article,,卷期:2012年31-7]
- The constitutively active serine/threonine kinase Pim-1 is upregulated in different cancer types, mainly based on the action of several interleukines and growth factors at the transcriptional level. So far, a regulation ...
- New pyrazolo[3,4-d] pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization
[作者:Indovina, P; Giorgi, F; Rizzo, V; Khadang, B; Schenone, S; Di Marzo, D; Forte, IM; Tomei, V; Mattioli, E; D'Urso, V; Grilli, B; Botta, M; Giordano, A; Pentimalli, F,期刊:Oncogene, 页码:929-938 , 文章类型: Article,,卷期:2012年31-7]
- Malignant mesothelioma (MM) is a highly aggressive tumor of the serous membranes for which there is currently no effective curative modality. Recent data suggest that hyperactivation of the tyrosine kinase SRC has a key ...
- MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells
[作者:Lakshmanan, I; Ponnusamy, MP; Das, S; Chakraborty, S; Haridas, D; Mukhopadhyay, P; Lele, SM; Batra, SK,期刊:Oncogene, 页码:805-817 , 文章类型: Article,,卷期:2012年31-7]
- MUC16/CA125 is a tumor marker currently used in clinics for the follow-up of patients with ovarian cancer. However, MUC16 expression is not entirely restricted to ovarian malignancies and has been reported in other cance...
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