- Oral Administration of 1,4-Aryl-2-mercaptoimidazole Inhibits T-Cell Proliferation and Reduces Clinical Severity in the Murine Experimental Autoimmune Encephalomyelitis Model
[作者:Jung, EJ; Hur, M; Kim, YL; Lee, GH; Kim, J; Kim, I; Lee, M; Han, HK; Kim, MS; Hwang, S; Kim, S; Woo, AM; Yoon, Y; Park, HJ; Won, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1005-1013 , 文章类型: Article,,卷期:2009年331-3]
- T cells play a pivotal role in the initiation and progression of multiple sclerosis. We have found that 1,4-aryl-2-mercaptoimidazole (KRM-III) inhibited T-cell antigen receptor- and phorbol myristate acetate/ionomycin-in...
- Effect of Intra-articular 4-(S)-Amino-5-(4-{4-[2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2H-4-pyranylcarbonyl} piperazino)-5-oxopentyl](trimethyl)ammonium chloride hydrochloride (MEN16132), a Kinin B-2 Receptor Antagonist, on Nociceptive Response in Monosodium Iodoacetate-Induced Experimental Osteoarthritis in Rats
[作者:Cialdai, C; Giuliani, S; Valenti, C; Tramontana, M; Maggi, CA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1025-1032 , 文章类型: Article,,卷期:2009年331-3]
- The present study was designed to investigate the role of bradykinin (BK) in the knee joint osteoarthritis induced by intraarticular (i.ar.) administration of monosodium iodoacetate (MIA) in the rat, and to determine the...
- Effectiveness of Donepezil, Rivastigmine, and (+/-)Huperzine A in Counteracting the Acute Toxicity of Organophosphorus Nerve Agents: Comparison with Galantamine
[作者:Aracava, Y; Pereira, EFR; Akkerman, M; Adler, M; Albuquerque, EX,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1014-1024 , 文章类型: Article,,卷期:2009年331-3]
- Galantamine, a centrally acting cholinesterase (ChE) inhibitor and a nicotinic allosteric potentiating ligand used to treat Alzheimer's disease, is an effective and safe antidote against poisoning with nerve agents, incl...
- Omigapil Ameliorates the Pathology of Muscle Dystrophy Caused by Laminin-alpha 2 Deficiency
[作者:Erb, M; Meinen, S; Barzaghi, P; Sumanovski, LT; Courdier-Fruh, I; Ruegg, MA; Meier, T,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:787-795 , 文章类型: Article,,卷期:2009年331-3]
- Laminin alpha 2-deficient congenital muscular dystrophy, called MDC1A, is a rare, devastating genetic disease characterized by severe neonatal hypotonia ("floppy infant syndrome"), peripheral neuropathy, inability to sta...
- Effect of the Calcimimetic R-568 [3-(2-Chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on Correcting Inactivating Mutations in the Human Calcium-Sensing Receptor
[作者:Lu, JYL; Yang, YH; Gnacadja, G; Christopoulos, A; Reagan, JD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:775-786 , 文章类型: Article,,卷期:2009年331-3]
- Over 257 mutations in the human calcium-sensing receptor (hCaSR) gene have been reported. Heterozygous inactivating mutations can result in familial hypocalciuric hypercalcemia (FHH), whereas homozygous inactivating muta...
- Involvement of Cyclooxygenase-2 in Carbachol-Induced Positive Inotropic Response in Mouse Isolated Left Atrium
[作者:Hara, Y; Ike, A; Tanida, R; Okada, M; Yamawaki, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:808-815 , 文章类型: Article,,卷期:2009年331-3]
- The mouse heart is expected to have characteristic contractile properties. However, basic information on the function of the mouse heart has not been accumulated sufficiently. In this study, the involvement of cyclooxyge...
- PPAR-alpha Contributes to the Anti-Inflammatory Activity of 17 beta-Estradiol
[作者:Crisafulli, C; Bruscoli, S; Esposito, E; Mazzon, E; Di Paola, R; Genovese, T; Bramanti, P; Migliorati, G; Cuzzocrea, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:796-807 , 文章类型: Article,,卷期:2009年331-3]
- Because studies have shown that 17 beta-estradiol (E2) produces anti-inflammatory effects after various adverse circulatory conditions, we have recently demonstrated that E2 significantly reduced the acute lung injury. M...
- Neuroprotective Profile of Novel Src Kinase Inhibitors in Rodent Models of Cerebral Ischemia
[作者:Liang, S; Pong, K; Gonzales, C; Chen, Y; Ling, HP; Mark, RJ; Boschelli, F; Boschelli, DH; Ye, F; Sosa, ACB; Mansour, TS; Frost, P; Wood, A; Pangalos, MN; Zaleska, MM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:827-835 , 文章类型: Article,,卷期:2009年331-3]
- Src kinase signaling has been implicated in multiple mechanisms of ischemic injury, including vascular endothelial growth factor (VEGF)-mediated vascular permeability that leads to vasogenic edema, a major clinical compl...
- Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]
[作者:Jobson, AG; Lountos, GT; Lorenzi, PL; Llamas, J; Connelly, J; Cerna, D; Tropea, JE; Onda, A; Zoppoli, G; Kondapaka, S; Zhang, GT; Caplen, NJ; Cardellina, JH; Yoo, SS; Monks, A; Self, C; Waugh, DS; Shoemaker, RH; Pommier, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:816-826 , 文章类型: Article,,卷期:2009年331-3]
- Chk2 is a checkpoint kinase involved in the ataxia telangiectasia mutated pathway, which is activated by genomic instability and DNA damage, leading to either cell death (apoptosis) or cell cycle arrest. Chk2 provides an...
- Selective Enhancement of Nutrient-Induced Insulin Secretion by ATP-Sensitive K+ Channel-Blocking Imidazolines
[作者:Hatlapatka, K; Wienbergen, A; Kuhne, C; Jorns, A; Willenborg, M; Rustenbeck, I,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1033-1041 , 文章类型: Article,,卷期:2009年331-3]
- The contribution of ATP-sensitive K+ channel (K-ATP channel)-dependent and -independent signaling to the insulinotropic characteristics of imidazolines was explored using perifused mouse islets and beta-cells. Up to a co...
- Phosphodiesterase 5A Inhibitors Improve Functional Recovery after Stroke in Rats: Optimized Dosing Regimen with Implications for Mechanism
[作者:Menniti, FS; Ren, JM; Coskran, TM; Liu, J; Morton, D; Sietsma, DK; Som, A; Stephenson, DT; Tate, BA; Finklestein, SP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:842-850 , 文章类型: Article,,卷期:2009年331-3]
- Phosphodiesterase 5A (PDE5A) inhibitors improve functional recovery after middle cerebral artery occlusion (MCA-o) in rats. We used the PDE5A inhibitor 3-(4-(2-hydroxyethyl)piperazin-1-yl)-7-(6-methoxypyridin-3-yl)-1-(2-...
- A Study of the Specificity of Lymphocytes in Nevirapine-Induced Skin Rash
[作者:Chen, X; Tharmanathan, T; Mannargudi, B; Gou, H; Uetrecht, JP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:836-841 , 文章类型: Article,,卷期:2009年331-3]
- Nevirapine treatment can cause a skin rash. We developed an animal model of this rash and determined that the 12-hydroxylation metabolic pathway is responsible for the rash, and treatment of animals with 12-OH-nevirapine...
- Adenosine Suppresses Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Production by Murine Macrophages through a Protein Kinase A- and Exchange Protein Activated by cAMP-Independent Signaling Pathway
[作者:Kreckler, LM; Gizewski, E; Wan, TC; Auchampach, JA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1051-1061 , 文章类型: Article,,卷期:2009年331-3]
- Adenosine is generated during tissue hypoxia and stress, which reduces inflammation by suppressing the activity of most immune cells. Among its various actions, adenosine suppresses the production of proinflammatory cyto...
- Pharmacological Characterization of 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionicAcid (AM103), a Novel Selective 5-Lipoxygenase-Activating Protein Inhibitor That Reduces Acute and Chronic Inflammation
[作者:Lorrain, DS; Bain, G; Correa, LD; Chapman, C; Broadhead, AR; Santini, AM; Prodanovich, P; Darlington, JV; Hutchinson, JH; King, C; Lee, C; Baccei, C; Li, YW; Arruda, JM; Evans, JF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1042-1050 , 文章类型: Article,,卷期:2009年331-3]
- Leukotrienes (LTs) are proinflammatory lipid mediators synthesized by the conversion of arachidonic acid (AA) to LTA(4) by the enzyme 5-lipoxygenase (5-LO) in the presence of 5-LO-activating protein (FLAP). 3-[3-tert-But...
- Contribution of the Prostaglandin E-2/E-Prostanoid 2 Receptor Signaling Pathway in Abscess Formation in Rat Zymosan-Induced Pleurisy
[作者:Inada, T; Arai, K; Kawamura, M; Hatanaka, K; Sato, Y; Noshiro, M; Harada, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:860-870 , 文章类型: Article,,卷期:2009年331-3]
- Abscess formation is a classic host response to infection by many pathogenic microorganisms. Here, we studied the role of prostaglandins (PGs) and their signal transduction in abscess formation. Zymosan was injected into...
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