- Structure of human porphobilinogen deaminase at 2.8 angstrom: the molecular basis of acute intermittent porphyria
[作者:Gill, R; Kolstoe, SE; Mohammed, F; Al D-Bass, A; Mosely, JE; Sarwar, M; Cooper, JB; Wood, SP; Shoolingin-Jordan, PM,期刊:Biochemical Journal, 页码:17-25 , 文章类型: Article,,卷期:2009年420-Part 1]
- Mutations in the human PBGD (porphobilinogen deaminase) gene cause the inherited defect AIP (acute intermittent porphyria). In the present study we report the structure of the human uPBGD (ubiquitous PBGD) mutant, R167Q,...
- Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells
[作者:Radichev, IA; Remacle, AG; Sounni, NE; Shiryaev, SA; Rozanov, DV; Zhu, WH; Golubkova, NV; Postnova, TI; Golubkov, VS; Strongin, AY,期刊:Biochemical Journal, 页码:37-47 , 文章类型: Article,,卷期:2009年420-Part 1]
- Invasion-promoting MT1-MMP (membrane type-1 matrix metalloproteinase) is a key element in cell migration processes. To identify the proteins that interact and therefore co-precipitate with this proteinase from cancer cel...
- In vivo regulatory phosphorylation of the phosphoenolpyruvate carboxylase AtPPC1 in phosphate-starved Arabidopsis thaliana
[作者:Gregory, AL; Hurley, BA; Tran, HT; Valentine, AJ; She, YM; Knowles, VL; Plaxton, WC,期刊:Biochemical Journal, 页码:57-65 , 文章类型: Article,,卷期:2009年420-Part 1]
- PEPC [PEP(phosphoenolpyruvate) carboxylase] is a tightly controlled cytosolic enzyme Situated at a major branchpoint in plant metabolism. Accumulating evidence indicates important functions for PEPC and PPCK (PEPC kinase...
- Modular regulation analysis of integrative effects of hypoxia on the energetics of contracting skeletal muscle in vivo
[作者:Beuste, C; Miraux, S; Deschodt-Arsac, WJ; Thiaudiere, E; Franconi, JM; Diolez, P; Arsac, LM,期刊:Biochemical Journal, 页码:67-72 , 文章类型: Article,,卷期:2009年420-Part 1]
- In the exercising muscle, acute reduction in ambient oxygen impairs muscle contraction because of the effects of hypoxia on mitochondrial ATP supply. The less marked impairment reported after long-term exposure to hypoxi...
- Sensitization of imatinib-resistant CML cells to TRAIL-induced apoptosis is mediated through down-regulation of Bcr-Abl as well as c-FLIP
[作者:Park, SJ; Kim, MJ; Kim, HB; Kang, CD; Kim, SH,期刊:Biochemical Journal, 页码:73-81 , 文章类型: Article,,卷期:2009年420-Part 1]
- Resistance to imatinib is commonly associated with reactivation of Bcr-Abl signalling. However, Bcr-Abl-independent signalling pathways may be activated and contributed to imatinib resistance in some CML (chronic myeloge...
- Plasma membrane microdomains from hybrid aspen cells are involved in cell wall polysaccharide biosynthesis
[作者:Bessueille, L; Sindt, N; Guichardant, M; Djerbi, S; Teeri, TT; Bulone, V,期刊:Biochemical Journal, 页码:93-103 , 文章类型: Article,,卷期:2009年420-Part 1]
Detergent-resistant plasma membrane microdomains [DRMs (detergent-resistant membranes)] were isolated recently from several plant species. As for animal cells, a large range of cellular functions, such as signal trans...
- Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays
[作者:Maretzky, T; Yang, GL; Ouerfelli, O; Overall, CM; Worpenberg, S; Hassiepen, U; Eder, J; Blobel, CP,期刊:Biochemical Journal, 页码:105-113 , 文章类型: Article,,卷期:2009年420-Part 1]
- 15 (a disintegrin and metalloproteinase 15) is a membrane-anchored metalloproteinase, which is overexpressed in several human cancers and has been implicated in pathological neovascularization and prostate cancer metasta...
- Co-activator SRC-1 is dispensable for transcriptional control by STAT3
[作者:Cvijic, H; Bauer, K; Loffler, D; Pfeifer, G; Blumert, C; Kretzschmar, AK; Henze, C; Brocke-Heidrich, K; Horn, F,期刊:Biochemical Journal, 页码:123-132 , 文章类型: Article,,卷期:2009年420-Part 1]
- SRC (steroid receptor co-activator)-1 has been reported to interact with and to be an essential co-activator for several members of the STAT (signal transducer and activator of transcription) family, including STAT3, the...
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