- Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway
[作者:Koka, V; Huang, XR; Chung, ACK; Wang, W; Truong, LD; Lan, HY,期刊:American Journal of Pathology, 页码:1174-1183 , 文章类型: Article,,卷期:2008年172-5]
- The recent discovery of the angiotensin II (Ang II)-breakdown enzyme, angiotensin I converting enzyme (ACE) 2, suggests the importance of Ang H degradation in hypertension. The present study explored the signaling mechan...
- Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappa B activity in conditions of oxidative stress
[作者:Boncoeur, E; Roque, T; Bonvin, E; Saint-Criq, V; Bonora, M; Clement, A; Tabary, O; Henrion-Caude, A; Jacquot, J,期刊:American Journal of Pathology, 页码:1184-1194 , 文章类型: Article,,卷期:2008年172-5]
- Cystic fibrosis is a lethal inherited disorder caused by mutations in a single gene encoding the cystic fibrosis transmembrane conductance regulator (CFrR) protein, resulting in progressive oxidative lung damage. in this...
- Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation
[作者:Cihakova, D; Barin, JG; Afanasyeva, M; Kimura, M; Fairweather, D; Berg, M; Talor, MV; Baldeviano, GC; Frisancho, S; Gabrielson, K; Bedja, D; Rose, NR,期刊:American Journal of Pathology, 页码:1195-1208 , 文章类型: Article,,卷期:2008年172-5]
- We report here that interleukin (IL)-13 protects BALB/c mice from myocarditis, whether induced by peptide immunization or by viral infection. In contrast to mild disease in IL-4 knockout (KO) BALB/c mice, IL-13 KO BALB/c...
- A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis
[作者:Trujillo, G; O'Connor, EC; Kunkel, SL; Hogaboam, CM,期刊:American Journal of Pathology, 页码:1209-1221 , 文章类型: Article,,卷期:2008年172-5]
- Macrophage polarization into M1 or M2 phenotypes dictates the nature, duration, and severity of an inflammatory response. The objective of this study was to examine the role of CC chemokine receptor 4 (CCR4) in macrophag...
- Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice
[作者:Yao, HW; Edirisinghe, I; Yang, SR; Rajendrasozhan, S; Kode, A; Caito, S; Adenuga, D; Rahman, I,期刊:American Journal of Pathology, 页码:1222-1237 , 文章类型: Article,,卷期:2008年172-5]
- Cigarette smoke (CS) induces recruitment of inflammatory cells in the lungs leading to the generation of reactive oxygen species (ROS), which are involved in lung inflammation and injury. Nicotinamide adenine dinucleotid...
- Deletion of the met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro
[作者:del Castillo, G; Factor, VM; Fernandez, M; Alvarez-Barrientos, A; Fabregat, I; Thorgeirsson, SS; Sanchez, A,期刊:American Journal of Pathology, 页码:1238-1247 , 文章类型: Article,,卷期:2008年172-5]
- The hepatocyte growth factor (HGF)/Met signaling system is essential for liver development, homeostasis, and function. in this study, we took advantage of a liver-specific, Met-conditional knockout mouse generated in our...
- Topical thymidine dinucleotide treatment reduces development of ultraviolet-induced basal cell carcinoma in Ptch-1(+/-) mice
[作者:Arad, S; Zattra, E; Hebert, J; Epstein, EH; Goukassian, DA; Gilchrest, BA,期刊:American Journal of Pathology, 页码:1248-1255 , 文章类型: Article,,卷期:2008年172-5]
- Treatment with thymidine dinucleotide (pTT) has well documented DNA-protective effects and reduces development of squamous cell carcinoma in UV-irradiated mice. The preventive effect of pTT on basal cell carcinoma (BCC) ...
- Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity
[作者:Chen, P; McGuire, JK; Hackman, RC; Kim, KH; Black, RA; Poindexter, K; Yan, W; Liu, P; Chen, AJ; Parks, WC; Madtes, DK,期刊:American Journal of Pathology, 页码:1256-1270 , 文章类型: Article,,卷期:2008年172-5]
- Obliterative bronchiolitis (OB) is the histopathological finding in chronic lung allograft rejection. Mounting evidence suggests that epithelial damage drives the development of airway fibrosis in OB. Tissue inhibitor of...
- Absence of alpha v beta 6 integrin is linked to initiation and progression of periodontal disease
[作者:Ghannad, F; Nica, D; Fulle, MIG; Grenier, D; Putnins, EE; Johnston, S; Eslami, A; Koivisto, L; Jiang, GQ; McKee, MD; Hakkinen, L; Larjava, H,期刊:American Journal of Pathology, 页码:1271-1286 , 文章类型: Article,,卷期:2008年172-5]
- Integrin alpha v beta 6 is generally not expressed in adult epithelia but is induced in wound healing, cancer, and certain fibrotic disorders. Despite this generalized absence, we observed that alpha v beta 6 integrin is...
- Antiprion prophylaxis by gene transfer of a soluble prion antagonist
[作者:Genoud, N; Ott, D; Braun, N; Prinz, M; Schwarz, P; Suter, U; Trono, D; Aguzzi, A,期刊:American Journal of Pathology, 页码:1287-1296 , 文章类型: Article,,卷期:2008年172-5]
- Prion diseases are untreatable neurodegenerative disorders characterized by accumulation of PrPsc, an aggregated isoform of the normal prion protein PrPc. Here, we delivered the soluble prion antagonist PrP-Fc(2) to the ...
- Transforming growth factor-beta 1-mediated slug and snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expression
[作者:Herfs, M; Hubert, P; Kholod, N; Caberg, JH; Gilles, C; Berx, G; Savagner, P; Boniver, J; Delvenne, P,期刊:American Journal of Pathology, 页码:1391-1402 , 文章类型: Article,,卷期:2008年172-5]
- Epithelial metaplasia (EpM) is an acquired tissue abnormality resulting from the transformation of epithelium into another tissue with a different structure and function. This adaptative process is associated with an inc...
- Molecular and cytogenetic characterization of plexiform leiomyomata provide further evidence for genetic heterogeneity underlying uterine fibroids
[作者:Hodge, JC; Quade, BJ; Rubin, MA; Stewart, EA; Dal Cin, P; Morton, CC,期刊:American Journal of Pathology, 页码:1403-1410 , 文章类型: Article,,卷期:2008年172-5]
- The plexiform variant of uterine leiomyomata (UL) is named for its ribbons or nests of smooth muscle cells that have a rounded, epithelioid shape caused by their entrapment in abundant extracellular matrix. Plexiform UL ...
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