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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   Strategies to Treat Substance Abuse and Addiction [作者：McCurdy, CR,期刊：Current Topics in Medicinal Chemistry, 页码：1102-1102 , 文章类型： Editorial Material，,卷期：2011年11-9] Design, Synthesis and Interaction at the Vesicular Monoamine Transporter-2 of Lobeline Analogs: Potential Pharmacotherapies for the Treatment of Psychostimulant Abuse [作者：Crooks, PA; Zheng, GR; Vartak, AP; Culver, JP; Zheng, F; Horton, DB; Dwoskin, LP,期刊：Current Topics in Medicinal Chemistry, 页码：1103-1127 , 文章类型： Review，,卷期：2011年11-9] The vesicular monoamine transporter-2 (VMAT2) is considered as a new target for the development of novel therapeutics to treat psychostimulant abuse. Current information on the structure, function and role of VMAT2 in ps... Sigma Receptors and Cocaine Abuse [作者：Narayanan, S; Mesangeau, C; Poupaert, JH; McCurdy, CR,期刊：Current Topics in Medicinal Chemistry, 页码：1128-1150 , 文章类型： Review，,卷期：2011年11-9] Sigma receptors have been well documented as a protein target for cocaine and have been shown to be involved in the toxic and stimulant actions of cocaine. Strategies to reduce the access of cocaine to sigma receptors ha... The Nociceptin/Orphanin FQ Receptor (NOP) as a Target for Drug Abuse Medications [作者：Zaveri, NT,期刊：Current Topics in Medicinal Chemistry, 页码：1151-1156 , 文章类型： Review，,卷期：2011年11-9] Several studies show that the nociceptin receptor NOP plays a role in the regulation of reward and motivation pathways related to substance abuse. Administration of the NOP's natural peptide ligand, Nociceptin/Orphanin F... Opioid Analgesics and P-Glycoprotein Efflux Transporters: A Potential Systems-Level Contribution to Analgesic Tolerance [作者：Mercer, SL; Coop, A,期刊：Current Topics in Medicinal Chemistry, 页码：1157-1164 , 文章类型： Review，,卷期：2011年11-9] Chronic clinical pain remains poorly treated. Despite attempts to develop novel analgesic agents, opioids remain the standard analgesics of choice in the clinical management of chronic and severe pain. However, mu opioid... Mitragyna speciosa, A Psychoactive Tree from Southeast Asia with Opioid Activity [作者：Adkins, JE; Boyer, EW; McCurdy, CR,期刊：Current Topics in Medicinal Chemistry, 页码：1165-1175 , 文章类型： Review，,卷期：2011年11-9] Mitragyna speciosa Korth. (Rubiaceae) is a tree that is commonly found in Southeast Asia. Leaves from this tree have been traditionally been used for both their stimulant properties as well as an opium substitute. The tr... GABA(A) Receptor Subtype-Selective Modulators. I. alpha 2/alpha 3-Selective Agonists as Non-Sedating Anxiolytics [作者：Atack, JR,期刊：Current Topics in Medicinal Chemistry, 页码：1176-1202 , 文章类型： Review，,卷期：2011年11-9] The prototypic benzodiazepines, such as diazepam, are not only anxiolytic but also produce sedation. These effects are mediated by GABA(A) receptors containing either an alpha 1, alpha 2, alpha 3 or alpha 5 subunit at wh... GABA(A) Receptor Subtype-Selective Modulators. II. alpha 5-Selective Inverse Agonists for Cognition Enhancement [作者：Atack, JR,期刊：Current Topics in Medicinal Chemistry, 页码：1203-1214 , 文章类型： Review，,卷期：2011年11-9] Benzodiazepine site agonists (such as diazepam) are well-known to impair cognition. Since benzodiazepines exert their effects via modulation of alpha 1-, alpha 2-, alpha 3- and alpha 5-containing GABA(A) receptors, the c...