- Triplet repeat length bias and variation in the human transcriptome
[作者:Molla, M; Delcher, A; Sunyaev, S; Cantor, C; Kasif, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17095-17100 , 文章类型: Article,,卷期:2009年106-40]
- Length variation in short tandem repeats (STRs) is an important family of DNA polymorphisms with numerous applications in genetics, medicine, forensics, and evolutionary analysis. Several major diseases have been associa...
- DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice
[作者:Albertson, TM; Ogawa, M; Bugni, JM; Hays, LE; Chen, Y; Wang, YP; Treuting, PM; Heddle, JA; Goldsby, RE; Preston, BD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17101-17104 , 文章类型: Article,,卷期:2009年106-40]
- Organisms require faithful DNA replication to avoid deleterious mutations. In yeast, replicative leading- and lagging-strand DNA polymerases (Pols epsilon and delta, respectively) have intrinsic proofreading exonucleases...
- Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias
[作者:Bahassi, E; Robbins, SB; Yin, MY; Boivin, GP; Kuiper, R; van Steeg, H; Stambrook, PJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17111-17116 , 文章类型: Article,,卷期:2009年106-40]
- The CHEK2 kinase (Chk2 in mouse) is a member of a DNA damage response pathway that regulates cell cycle arrest at cell cycle checkpoints and facilitates the repair of dsDNA breaks by a recombination-mediated mechanism. T...
- Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: Implications for Down syndrome
[作者:Chang, KT; Min, KT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17117-17122 , 文章类型: Article,,卷期:2009年106-40]
- At the neuronal level of Down syndrome (DS) brains, there are evidences of altered shape, number, and density of synapses, as well as aberrant endocytosis associated with accumulation of enlarged endosomes, suggesting th...
- A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome
[作者:Ranatunga, D; Hedrich, CM; Wang, FY; McVicar, DW; Nowak, N; Joshi, T; Feigenbaum, L; Grant, LR; Stager, S; Bream, JH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17123-17128 , 文章类型: Article,,卷期:2009年106-40]
- Interleukin (IL)-10 is an immunoregulatory cytokine that is produced by diverse cell populations. Studies in mice suggest that the cellular source of IL-10 is a key determinant in various disease pathologies, yet little ...
- CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens
[作者:Nitta, T; Nitta, S; Lei, Y; Lipp, M; Takahama, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17129-17133 , 文章类型: Article,,卷期:2009年106-40]
- Immature double-positive thymocytes are generated in the thymic cortex, and on positive selection, are induced to differentiate into mature single-positive thymocytes and relocate to the medulla. CCR7 is pivotal for cort...
- Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition
[作者:Zhou, PH; Fang, XF; McNally, BA; Yu, P; Zhu, MZ; Fu, YX; Wang, LZ; Liu, Y; Zheng, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17134-17139 , 文章类型: Article,,卷期:2009年106-40]
- The identification of individuals genetically susceptible to cancer calls for preventive measures to minimize the cancer risk in these high-risk populations. Immune prevention is made necessary by the anticipated health ...
- Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression
[作者:Paradisi, A; Maisse, C; Coissieux, MM; Gadot, N; Lepinasse, F; Delloye-Bourgeois, C; Delcros, JG; Svrcek, M; Neufert, C; Flejou, JF; Scoazec, JY; Mehlen, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17146-17151 , 文章类型: Article,,卷期:2009年106-40]
- Chronic inflammation and cancer are intimately associated. This is particularly true for inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, which show a major increased risk for colorectal...
- A strategy for blood biomarker amplification and localization using ultrasound
[作者:D'Souza, AL; Tseng, JR; Pauly, KB; Guccione, S; Rosenberg, J; Gambhir, SS; Glazer, GM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17152-17157 , 文章类型: Article,,卷期:2009年106-40]
- Blood biomarkers have significant potential applications in early detection and management of various diseases, including cancer. Most biomarkers are present in low concentrations in blood and are difficult to discrimina...
- Redox trapping of arsenic during groundwater discharge in sediments from the Meghna riverbank in Bangladesh
[作者:Datta, S; Mailloux, B; Jung, HB; Hoque, MA; Stute, M; Ahmed, KM; Zheng, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16930-16935 , 文章类型: Article,,卷期:2009年106-40]
- Groundwater arsenic (As) is elevated in the shallow Holocene aquifers of Bangladesh. In the dry season, the shallow groundwater discharges to major rivers. This process may influence the chemistry of the river and the hy...
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