- Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1
[作者:Kojo, S; Elly, C; Harada, Y; Langdon, WY; Kronenberg, M; Liu, YC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17847-17851 , 文章类型: Article,,卷期:2009年106-42]
- Repeated injection of alpha-galactosylceramide, an agonistic ligand for natural killer T (NKT) cells, results in long-term unresponsiveness or anergy, which severely limits its clinical application. However, the molecula...
- The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
[作者:Stanietsky, N; Simic, H; Arapovic, J; Toporik, A; Levy, O; Novik, A; Levine, Z; Beiman, M; Dassa, L; Achdout, H; Stern-Ginossar, N; Tsukerman, P; Jonjic, S; Mandelboim, O,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17858-17863 , 文章类型: Article,,卷期:2009年106-42]
- NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC class I proteins and are expressed in a variegated fashion. It was recently shown that TIGI...
- Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge
[作者:Brezski, RJ; Vafa, O; Petrone, D; Tam, SH; Powers, G; Ryan, MH; Luongo, JL; Oberholtzer, A; Knight, DM; Jordan, RE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17864-17869 , 文章类型: Article,,卷期:2009年106-42]
- The successful elimination of pathogenic cells and microorganisms by the humoral immune system relies on effective interactions between host immunoglobulins and Fc gamma receptors on effector cells, in addition to the co...
- A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA
[作者:Choi, MK; Wang, ZC; Ban, T; Yanai, H; Lu, Y; Koshiba, R; Nakaima, Y; Hangai, S; Savitsky, D; Nakasato, M; Negishi, H; Takeuchi, O; Honda, K; Akira, S; Tamura, T; Taniguchi, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17870-17875 , 文章类型: Article,,卷期:2009年106-42]
- The activation of the innate immune responses by DNA exposed within the cytosol has gained much attention and, in this context, several cytosolic DNA sensors have been identified. However, previous studies revealed the o...
- The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes
[作者:Jenner, RG; Townsend, MJ; Jackson, I; Sun, KM; Bouwman, RD; Young, RA; Glimcher, LH; Lord, GM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17876-17881 , 文章类型: Article,,卷期:2009年106-42]
- Upon detection of antigen, CD4(+) T helper (Th) cells can differentiate into a number of effector types that tailor the immune response to different pathogens. Alternative Th1 and Th2 cell fates are specified by the tran...
- Immunologically silent cancer clone transmission from mother to offspring
[作者:Isoda, T; Ford, AM; Tomizawa, D; van Delft, FW; de Castro, DG; Mitsuiki, N; Score, J; Taki, T; Morio, T; Takagi, M; Saji, H; Greaves, M; Mizutani, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17882-17885 , 文章类型: Article,,卷期:2009年106-42]
- Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring tra...
- Impaired tumor growth, metastasis, angiogenesis and wound healing in annexin A1-null mice
[作者:Yi, M; Schnitzer, JE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17886-17891 , 文章类型: Article,,卷期:2009年106-42]
- Despite 2 decades of research, no clear function for annexin A1 (AnxA1) has been established. Using AnxA1-KO mice, we show that tumor growth and metastasis are significantly decreased, whereas rodent survival and tumor n...
- CD4(+) T cells control the differentiation of Gr1(+) monocytes into fibrocytes
[作者:Niedermeier, M; Reich, B; Gomez, MR; Denzel, A; Schmidbauer, K; Gobel, N; Talke, Y; Schweda, F; Mack, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17892-17897 , 文章类型: Article,,卷期:2009年106-42]
- Fibrocytes are collagen-type-I-producing cells that arise at low frequency from hematopoietic cells. We have analyzed in mice which leukocyte subsets are required for generation of fibrocytes and show that murine fibrocy...
- High-throughput in vivo screening of targeted molecular imaging agents
[作者:Gagnon, MKJ; Hausner, SH; Marik, J; Abbey, CK; Marshall, JF; Sutcliffe, JL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17904-17909 , 文章类型: Article,,卷期:2009年106-42]
- The rapid development and translation of targeted molecular imaging agents from bench to bedside is currently a slow process, with a clear bottleneck between the discovery of new compounds and the development of an appro...
- Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
[作者:Lee, K; Zhang, HF; Qian, DZ; Rey, S; Liu, JO; Semenza, GL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17910-17915 , 文章类型: Article,,卷期:2009年106-42]
- HIF-1 is a heterodimeric transcription factor that mediates adaptive responses to hypoxia and plays critical roles in cancer progression. Using a cell-based screening assay we have identified acriflavine as a drug that b...
- Endosomes: A legitimate platform for the signaling train
[作者:Murphy, JE; Padilla, BE; Hasdemir, B; Cottrell, GS; Bunnett, NW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17615-17622 , 文章类型: Article,,卷期:2009年106-42]
- Although long regarded as a conduit for the degradation or recycling of cell surface receptors, the endosomal system is also an essential site of signal transduction. Activated receptors accumulate in endosomes, and cert...
- Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components
[作者:Stroupe, C; Hickey, CM; Mima, J; Burfeind, AS; Wickner, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17626-17633 , 文章类型: Article,,卷期:2009年106-42]
- Rab GTPases and their effectors mediate docking, the initial contact of intracellular membranes preceding bilayer fusion. However, it has been unclear whether Rab proteins and effectors are sufficient for intermembrane i...
- Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1
[作者:Kopp, SJ; Banisadr, G; Glajch, K; Maurer, UE; Grunewald, K; Miller, RJ; Osten, P; Spear, PG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17916-17920 , 文章类型: Article,,卷期:2009年106-42]
- Multiple entry receptors can mediate infection of cells by herpes simplex virus (HSV), permitting alternative pathways for infection and disease. We investigated the roles of two known entry receptors, herpesvirus entry ...
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