- Electrochemically controlled drug delivery based on intrinsically conducting polymers
[作者:Svirskis, D; Travas-Sejdic, J; Rodgers, A; Garg, S,期刊:Journal of controlled release, 页码:6-15 , 文章类型: Review,,卷期:2010年146-1]
- This paper reviews the application of intrinsically conducting polymers (ICPs) in drug delivery. ICPs are organic polymers with electrical, magnetic and optical properties usually associated with metals, whilst retaining...
- Molecular imaging analysis of intestinal insulin absorption boosted by cell-penetrating peptides by using positron emission tomography
[作者:Kamei, N; Morishita, M; Kanayama, Y; Hasegawa, K; Nishimura, M; Hayashinaka, E; Wada, Y; Watanabe, Y; Takayama, K,期刊:Journal of controlled release, 页码:16-22 , 文章类型: Article,,卷期:2010年146-1]
- Molecular imaging technique by use of positron emission tomography (PET) is a noninvasive tool that allows one to quantitatively analyze the function of endogenous molecules and the pharmacokinetics of therapeutic agents...
- Correlation of tissue drug concentrations with in vivo magnetic resonance images of polymer drug depot around arteriovenous graft
[作者:Owen, SC; Li, HA; Sanders, WG; Cheung, AK; Terry, CM,期刊:Journal of controlled release, 页码:23-30 , 文章类型: Article,,卷期:2010年146-1]
- Sustained delivery of anti-proliferative drugs to the perivascular area using an injectable polymeric platform is a strategy to inhibit vascular hyperplasia and stenosis. In this study, the concentrations of sirolimus in...
- Effect of controlled laser microporation on drug transport kinetics into and across the skin
[作者:Bachhav, YG; Summer, S; Heinrich, A; Bragagna, T; Bohler, C; Kalia, YN,期刊:Journal of controlled release, 页码:31-36 , 文章类型: Article,,卷期:2010年146-1]
- The objectives of this study were to investigate a novel laser microporation technology ( PLEASE. Painless Laser Epidermal System) and to determine the effect of pore number and depth on the rate and extent of drug deliv...
- 5-Fluorouracil-loaded multilayered films for drug controlled releasing stent application: Drug release, microstructure, and ex vivo permeation behaviors
[作者:Lei, L; Liu, X; Guo, SR; Tang, MF; Cheng, LA; Tian, L,期刊:Journal of controlled release, 页码:45-53 , 文章类型: Article,,卷期:2010年146-1]
- A series of poly(epsilon-caprolactone) (PCL)-based multilayered films containing antitumor 5-fluorouracil as stent struts were produced. A backing layer and a surface drug layer were applied to the main drug layer to rea...
- Artesunate-clindamycin multi-kinetics and site-specific oral delivery system for antimalaric combination products
[作者:Strusi, OL; Barata, P; Traini, D; Young, PM; Mercuri, S; Colombo, G; Sonvico, F; Bettini, R; Colombo, P,期刊:Journal of controlled release, 页码:54-60 , 文章类型: Article,,卷期:2010年146-1]
- The aim of this work was to study a multi-kinetics and site-specific oral antimalaria drug delivery system (MKS_DDS), containing artesunate and clindamycin, based on the Dome Matrix module assembly technology. The MKS_DD...
- Facile control of porous structures of polymer microspheres using an osmotic agent for pulmonary delivery
[作者:Lee, J; Oh, YJ; Lee, SK; Lee, KY,期刊:Journal of controlled release, 页码:61-67 , 文章类型: Article,,卷期:2010年146-1]
- It has been challenging to prepare polymeric microspheres with controlled porous structures for many biomedical applications, particularly for pulmonary drug delivery. Here, we report the use of bovine serum albumin (BSA...
- The encapsulation of idarubicin within liposomes using the novel EDTA ion gradient method ensures improved drug retention in vitro and in vivo
[作者:Gubernator, J; Chwastek, G; Korycinska, M; Stasiuk, M; Grynkiewicz, G; Lewrick, F; Sues, R; Kozubek, A,期刊:Journal of controlled release, 页码:68-75 , 文章类型: Article,,卷期:2010年146-1]
- The purpose of this study was to design a new stable liposomal formulation for the anticancer drug idarubicin. Idarubicin is a relatively hydrophobic member of the anthracycline family. It exhibits pronounced bilayer int...
- Delivery of zoledronic acid encapsulated in folate-targeted liposome results in potent in vitro cytotoxic activity on tumor cells
[作者:Shmeeda, H; Amitay, Y; Gorin, J; Tzemach, D; Mak, L; Ogorka, J; Kumar, S; Zhang, JA; Gabizon, A,期刊:Journal of controlled release, 页码:76-83 , 文章类型: Article,,卷期:2010年146-1]
- Introduction: Zoledronic acid (ZOL), a nitrogen-containing bisphosphonate, is a potent inhibitor of farnesylpyrophosphate synthase with poor in vitro cytotoxic activity as a result of its limited diffusion into tumor cel...
- Improvement of the monitoring and biosafety of encapsulated cells using the SFG(NES)TGL triple reporter system
[作者:Catena, R; Santos, E; Orive, G; Hernandez, RM; Pedraz, JL; Calvo, A,期刊:Journal of controlled release, 页码:93-98 , 文章类型: Article,,卷期:2010年146-1]
- Cell microencapsulation may represent a breakthrough to overcome problems associated with cell therapy. Advances in material biocompatibility and production protocols have put this field close to its clinical application...
- Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery
[作者:Navarro, G; Maiwald, G; Haase, R; Rogach, AL; Wagner, E; de Ilarduya, CT; Ogris, M,期刊:Journal of controlled release, 页码:99-105 , 文章类型: Article,,卷期:2010年146-1]
- Polyplexes consisting of a standard CMV promoter driven luciferase plasmid condensed with PAMAM starburst dendrimers (generation 4 and 5) efficiently transfected tumor cells in vitro. Tail vein injection of PAMAM polyple...
- In Vitro and In Vivo gene delivery mediated by Lactosylated Dendrimer/alpha-Cyclodextrin Conjugates (G2) into Hepatocytes
[作者:Arima, H; Yamashita, S; Mori, Y; Hayashi, Y; Motoyama, K; Hattori, K; Takeuchi, T; Jono, H; Ando, Y; Hirayama, F; Uekama, K,期刊:Journal of controlled release, 页码:106-117 , 文章类型: Article,,卷期:2010年146-1]
- The purpose of this study is to evaluate in vitro and in vivo gene delivery efficiency of polyamidoamine (PAMAM) starburst dendrimer (generation 2, G2) conjugates with a-cyclodextrin (alpha-CDE (G2)) bearing lactose (Lac...
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