- Albumin fusion of thioredoxin - The production and evaluation of its biological activity for potential therapeutic applications
[作者:Ikuta, S; Chuang, VTG; Ishima, Y; Nakajou, K; Furukawa, M; Watanabe, H; Maruyama, T; Otagiri, M,期刊:Journal of controlled release, 页码:17-23 , 文章类型: Article,,卷期:2010年147-1]
- Thioredoxin-1 (Trx) is a redox-active protein with anti-inflammatory effects. The effect of albumin fusion on the pharmacokinetic and pharmacodynamic properties of Trx was evaluated in this study. The findings indicate t...
- Sustained release of VEGF through PLGA microparticles improves vasculogenesis and tissue remodeling in an acute myocardial ischemia-reperfusion model
[作者:Formiga, FR; Pelacho, B; Garbayo, E; Abizanda, G; Gavira, JJ; Simon-Yarza, T; Mazo, M; Tamayo, E; Jauquicoa, C; Ortiz-de-Solorzano, C; Prosper, F; Blanco-Prieto, MJ,期刊:Journal of controlled release, 页码:30-37 , 文章类型: Article,,卷期:2010年147-1]
- The use of pro-angiogenic growth factors in ischemia models has been associated with limited success in the clinical setting, in part owing to the short lived effect of the injected cytokine. The use of a microparticle s...
- The effects of carrier nature and pH on rhBMP-2-induced ectopic bone formation
[作者:Luca, L; Rougemont, AL; Walpoth, BH; Gurny, R; Jordan, O,期刊:Journal of controlled release, 页码:38-44 , 文章类型: Article,,卷期:2010年147-1]
- Carrier nature and pH are important factors for rhBMP-2 osteoinductive activity. As for formulation pH, rhBMP-2 undergoes conformational changes and aggregates when shifting from acidic to neutral pH conditions. The pres...
- In situ fabrication of alendronate-loaded calcium phosphate microspheres: Controlled release for inhibition of osteoclastogenesis
[作者:Kim, CW; Yun, YP; Lee, HJ; Hwang, YS; Kwon, IK; Lee, SC,期刊:Journal of controlled release, 页码:45-53 , 文章类型: Article,,卷期:2010年147-1]
- Bioabsorbable calcium phosphate (CaP) microspheres that can incorporate alendronate (ALD) through an in situ loading process and can control the ALD release rate have been described. ALD loading into CaP microspheres cou...
- Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications
[作者:Jansen, J; Boerakker, MJ; Heuts, J; Feijen, J; Grijpma, DW,期刊:Journal of controlled release, 页码:54-61 , 文章类型: Article,,卷期:2010年147-1]
- Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable poly...
- In-vitro and in-vivo erosion profiles of hydroxypropylmethylcellulose (HPMC) matrix tablets
[作者:Ghimire, M; Hodges, LA; Band, J; O'Mahony, B; McInnes, FJ; Mullen, AB; Stevens, HNE,期刊:Journal of controlled release, 页码:70-75 , 文章类型: Article,,卷期:2010年147-1]
- The purpose of this study was to evaluate and compare the in-vitro and in-vivo erosion profiles of two tablet formulations primarily consisting of hydroxypropylmethylcellulose (HPMC) and lactose. HPMC was used at concent...
- Polymeric micelle gene delivery of bcl-x(L) via eye drop reduced corneal apoptosis following epithelial debridement
[作者:Tong, YC; Chang, SF; Kao, WWY; Liu, CY; Liaw, J,期刊:Journal of controlled release, 页码:76-83 , 文章类型: Article,,卷期:2010年147-1]
- Stromal keratocyte apoptosis triggered by epithelial injury is one mechanism of corneal disorders. A model of epithelial injury by epithelial debridement is established, and keratocyte apoptosis is evidenced by DNA fragm...
- Carbonate apatite-facilitated intracellularly delivered siRNA for efficient knockdown of functional genes
[作者:Hossain, S; Stanislaus, A; Chua, MJ; Tada, S; Tagawa, Y; Chowdhury, EH; Akaike, T,期刊:Journal of controlled release, 页码:101-108 , 文章类型: Article,,卷期:2010年147-1]
- Gene therapy through intracellular delivery of a functional gene or a gene-silencing element is a promising approach to treat critical diseases. Elucidation of the genetic basis of human diseases with complete sequencing...
- In-vivo tumor targeting of pluronic-based nano-carriers
[作者:Kim, JY; Il Choi, W; Kim, YH; Tae, G; Lee, SY; Kim, K; Kwon, IC,期刊:Journal of controlled release, 页码:109-117 , 文章类型: Article,,卷期:2010年147-1]
- Pluronic-based nano-carriers including bare forms that were composed of Pluronic F 68(NC(PF 68)) or Pluronic F 127(NC(PF 127)), and chitosan-conjugated forms (Chito-NC(PF 68) or Chito-NC(PF 127)) were prepared by photo-p...
- Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain
[作者:Shao, K; Huang, RQ; Li, JF; Han, LA; Ye, LY; Lou, JN; Jiang, C,期刊:Journal of controlled release, 页码:118-126 , 文章类型: Article,,卷期:2010年147-1]
- Amphotericin B (AmB) is a poorly water soluble antibiotic and is used to treat fungal infections of the central nervous system (CNS). However, AmB shows poor penetration into the CNS. Angiopep-2, the ligand of low-densit...
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