Cangrelor (AR-C69931MX) is a nonthienopyridine direct-acting P2Y(12) antagonist under development for the treatment of acute coronary syndrome and as an ultrafast-acting intravenous antithrombotic agent. Cangrelor inh...

Tachykinins are widely expressed endogenous peptides in mammals endowed with physiological and pathophysiological effects. The potent effects of tachykinins on smooth muscle, local inflammatory effects and visceral hy...

Calcitonin gene-related peptide (CGRP) has been suggested to play a key role in migraine pathophysiology. MK-0974, an oral CGRP receptor antagonist, is being developed by Merck for the treatment of acute migraine atta...

Human epidermal growth factor receptor 2 (HER2) is an important driver of malignant growth and progression in many cancer types and is activated through dimerization with itself or other HER family members. Targeting ...

The inflammatory symptoms of psoriasis are caused in part by the infiltration of T-cells into the affected areas of the skin and their differentiation to Th1- and Th17-type effector cells. The interleukins IL-12 and I...

Certain bispecific antibodies hold promise for redirecting cytotoxic T-cells, the body's most effective killer cells, against malignant cells. This cannot be achieved by conventional monoclonal antibodies because T-ce...

Our group has been conducting a search for compounds for dementia derived from medicinal mushrooms since 1991. A series of benzyl alcohol derivatives (named hericenones C to H), as well as a series of diterpenoid deri...

We have not exhausted all strategies to develop an effective AIDS vaccine. We are continually learning more about the human immunodeficiency virus (HIV), different types of vaccines appear every day and we are also le...

The Kit receptor, or the receptor for stem cell factor (SCIF), is a member of the type III subclass of receptor tyrosine kinases (RTKs). Signaling by SCIF and Kit plays an important role in hematopoiesis, gametogenesi...

Protein-tyrosine phosphatases (PTPs) play crucial roles in intracellular signaling. Regulating tyrosine phosphorylation levels ultimately controls gene transcription, metabolism, cell growth and differentiation, cell ...

Mastocytosis is a heterogeneous group of disorders characterized by clonal expansion of mast cells. Clinical course can range from no or minimal symptoms to diffuse systemic involvement with multiorgan failure. The di...