ASA404 (DMXAA, formerly AS1404) was originaly synthesized at the Auckland Cancer Society Research Centre in an effort to identfy more active analogues of flavone acetic acid (FAA). Phasse I trials of ASA404 were based...

Linaclotide acetate (MD-1100) is a novel, orally administered agent currently in development for the treatment of gastrointestinal disorders, including irritable bowel syndrome with predominant constipation (IBS-C) an...

Targeting glucagon-like peptide 1 (GLP-1) is an attractive strategy for the treatment of type 2 diabetes, as this incretin hormone enhances postprandial insulin secretion in a manner dependent on glycemia. Evidence al...

Non-small cell lung cancer (NSCLC) accounts for approximately 75% of all lung cancers, the leading cause of cancer-related deaths in both men and women worldwide. Advances in vaccine therapy strategies, designed to st...

The World Health Organization (WHO) has predicted that depression will be the number two disabling condition worldwide by 2020. The increasing number of patients with recognized depressive disorders has caused a consi...

Inhibition of steroid sulfatase (STS) activity in skin is a potential new treatment strategy for a number of skin disorders, including hirsutism, androgen-dependent alopecia, acne and psoriasis. In skin and its append...

Friedreich's ataxia (FRDA) is the most common cause of early-onset ataxia in the Western world. It is, caused by lack of the mitochondrial protein frataxin. Frataxin deficiency leads to impaired iron-sulfur cluster bi...

Melanoma is a highly aggressive, therapy-resistant malignant tumor that originates when melanocytes are injured and transformed by ultraviolet radiation, or as a consequence of exposure to environmental agents in a ge...

,The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) took place in the coastal city of Fort Lauderdale, Florida, on April 27-May 1, 2008, where over 10,000 basic and clinical eye and ...