- Dengue Virus Capsid Protein Binding to Hepatic Lipid Droplets (LD) Is Potassium Ion Dependent and Is Mediated by LD Surface Proteins
[作者:Carvalho, FA; Carneiro, FA; Martins, IC; Assuncao-Miranda, I; Faustino, AF; Pereira, RM; Bozza, PT; Castanho, MARB; Mohana-Borges, R; Da Poian, AT; Santos, NC,期刊:Journal of virology, 页码:2096-2108 , 文章类型: Article,,卷期:2012年86-4]
- Dengue virus (DENY) affects millions of people, causing more than 20,000 deaths annually. No effective treatment for the disease caused by DENV infection is currently available, partially due to the lack of knowledge on ...
- Development of a Novel Nonhuman Primate Model for Rift Valley Fever
[作者:Smith, DR; Bird, BH; Lewis, B; Johnston, SC; McCarthy, S; Keeney, A; Botto, M; Donnelly, G; Shamblin, J; Albarino, CG; Nichol, ST; Hensley, LE,期刊:Journal of virology, 页码:2109-2120 , 文章类型: Article,,卷期:2012年86-4]
- Rift Valley fever (RVF) virus (RVFV) can cause severe human disease characterized by either acute-onset hepatitis, delayed-onset encephalitis, retinitis and blindness, or a hemorrhagic syndrome. The existing nonhuman pri...
- A Non-Mouse-Adapted Enterovirus 71 (EV71) Strain Exhibits Neurotropism, Causing Neurological Manifestations in a Novel Mouse Model of EV71 Infection
[作者:Khong, WX; Yan, B; Yeo, HM; Tan, EL; Lee, JJ; Ng, JKW; Chow, VT; Alonso, S,期刊:Journal of virology, 页码:2121-2131 , 文章类型: Article,,卷期:2012年86-4]
- Enterovirus 71 (EV71) is a neurotropic pathogen that has been consistently associated with the severe neurological forms of hand, foot, and mouth disease. The lack of a relevant animal model has hampered our understandin...
- Natural Killer Cells Regulate Murine Cytomegalovirus-Induced Sialadenitis and Salivary Gland Disease
[作者:Carroll, VA; Lundgren, A; Wei, HR; Sainz, S; Tung, KS; Brown, MG,期刊:Journal of virology, 页码:2132-2142 , 文章类型: Article,,卷期:2012年86-4]
- The transmission of herpesviruses depends on viral shedding at mucosal surfaces. The salivary gland represents a major site of persistent viral replication for many viruses, including cytomegalovirus. We established a mo...
- Production of Infectious Chimeric Hepatitis C Virus Genotype 2b Harboring Minimal Regions of JFH-1
[作者:Murayama, A; Kato, T; Akazawa, D; Sugiyama, N; Date, T; Masaki, T; Nakamoto, S; Tanaka, Y; Mizokami, M; Yokosuka, O; Nomoto, A; Wakita, T,期刊:Journal of virology, 页码:2143-2152 , 文章类型: Article,,卷期:2012年86-4]
- To establish a cell culture system for chimeric hepatitis C virus (HCV) genotype 2b, we prepared a chimeric construct harboring the 5' untranslated region (UTR) to the E2 region of the MA strain (genotype 2b) and the reg...
- High-Mannose Glycan-Dependent Epitopes Are Frequently Targeted in Broad Neutralizing Antibody Responses during Human Immunodeficiency Virus Type 1 Infection
[作者:Lavine, CL; Lao, S; Montefiori, DC; Haynes, BF; Sodroski, JG; Yang, XZ,期刊:Journal of virology, 页码:2153-2164 , 文章类型: Article,,卷期:2012年86-4]
- Broad and potent neutralizing antibody (BNAb) responses are rare in people infected by human immunodeficiency virus type 1 (HIV-1). Clearly defining the nature of BNAb epitopes on HIV-1 envelope glycoproteins (Envs) targ...
- The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8(+) T-Cell Response
[作者:Mitrovic, M; Arapovic, J; Jordan, S; Fodil-Cornu, N; Ebert, S; Vidal, SM; Krmpotic, A; Reddehase, MJ; Jonjic, S,期刊:Journal of virology, 页码:2165-2175 , 文章类型: Article,,卷期:2012年86-4]
- Natural killer (NK) cells and CD8(+) T cells play a prominent role in the clearance of mouse cytomegalovirus (MCMV) infection. The role of NK cells in modulating the CD8(+) T-cell response to MCMV infection is still the ...
- The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism
[作者:Vera-Otarola, J; Solis, L; Soto-Rifo, R; Ricci, EP; Pino, K; Tischler, ND; Ohlmann, T; Darlix, JL; Lopez-Lastra, M,期刊:Journal of virology, 页码:2176-2187 , 文章类型: Article,,卷期:2012年86-4]
- The small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein. In 4 out of 5 genera in the Bunyaviridae, the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show tha...
- Inhibition of TANK Binding Kinase 1 by Herpes Simplex Virus 1 Facilitates Productive Infection
[作者:Ma, YJ; Jin, HL; Valyi-Nagy, T; Cao, YJ; Yan, ZP; He, B,期刊:Journal of virology, 页码:2188-2196 , 文章类型: Article,,卷期:2012年86-4]
- The gamma(1)34.5 protein of herpes simplex viruses (HSV) is essential for viral pathogenesis, where it precludes translational arrest mediated by double-stranded-RNA-dependent protein kinase (PKR). Paradoxically, inhibit...
- Viral Interferon Regulatory Factors Decrease the Induction of Type I and Type II Interferon during Rhesus Macaque Rhadinovirus Infection
[作者:Robinson, BA; Estep, RD; Messaoudi, I; Rogers, KS; Wong, SW,期刊:Journal of virology, 页码:2197-2211 , 文章类型: Article,,卷期:2012年86-4]
- Kaposi's sarcoma-associated herpesvirus and rhesus macaque rhadinovirus (RRV), two closely related gammaherpesviruses, are unique in their expression of viral homologs of cellular interferon regulatory factors (IRFs), te...
- Origin and Evolution of the Unique Hepatitis C Virus Circulating Recombinant Form 2k/1b
[作者:Raghwani, J; Thomas, XV; Koekkoek, SM; Schinkel, J; Molenkamp, R; van de Laar, TJ; Takebe, Y; Tanaka, Y; Mizokami, M; Rambaut, A; Pybus, OG,期刊:Journal of virology, 页码:2212-2220 , 文章类型: Article,,卷期:2012年86-4]
- Since its initial identification in St. Petersburg, Russia, the recombinant hepatitis C virus (HCV) 2k/1b has been isolated from several countries throughout Eurasia. The 2k/1b strain is the only recombinant HCV to have ...
- Hepatitis C Virus Proteins Inhibit C3 Complement Production
[作者:Mazumdar, B; Kim, H; Meyer, K; Bose, SK; Di Bisceglie, AM; Ray, RB; Ray, R,期刊:Journal of virology, 页码:2221-2228 , 文章类型: Article,,卷期:2012年86-4]
- The third component of human complement (C3) plays a central role in innate immune function as its activation is required to trigger classical as well as alternative complement pathways. In this study, we have observed t...
- Seasonal H1N1 Influenza Virus Infection Induces Cross-Protective Pandemic H1N1 Virus Immunity through a CD8-Independent, B Cell-Dependent Mechanism
[作者:Fange, Y; Banner, D; Kelvin, AA; Huang, SSH; Paige, CJ; Corfe, SA; Kane, KP; Bleackley, RC; Rowe, T; Leon, AJ; Kelvin, DJ,期刊:Journal of virology, 页码:2229-2238 , 文章类型: Article,,卷期:2012年86-4]
- During the 2009 HIN1 influenza virus pandemic (pdmH1N1) outbreak, it was found that most individuals lacked antibodies against the new pdmH1N1 virus, and only the elderly showed anti-hemagglutinin (anti-HA) antibodies th...
- Low-Dose Penile SIVmac251 Exposure of Rhesus Macaques Infected with Adenovirus Type 5 (Ad5) and Then Immunized with a Replication-Defective Ad5-Based SIV gag/pol/nef Vaccine Recapitulates the Results of the Phase IIb Step Trial of a Similar HIV-1 Vaccine
[作者:Qureshi, H; Ma, ZM; Huang, Y; Hodge, G; Thomas, MA; DiPasquale, J; DeSilva, V; Fritts, L; Bett, AJ; Casimiro, DR; Shiver, JW; Robert-Guroff, M; Robertson, MN; McChesney, MB; Gilbert, PB; Miller, CJ,期刊:Journal of virology, 页码:2239-2250 , 文章类型: Article,,卷期:2012年86-4]
- The Step Trial showed that the MRKAd5 HIV-1 subtype B Gag/Pol/Nef vaccine did not protect men from HIV infection or reduce setpoint plasma viral RNA (vRNA) levels but, unexpectedly, it did modestly enhance susceptibility...
- Natural Killer Cells Are Involved in Acute Lung Immune Injury Caused by Respiratory Syncytial Virus Infection
[作者:Li, FA; Zhu, HQ; Sun, R; Wei, HM; Tian, ZG,期刊:Journal of virology, 页码:2251-2258 , 文章类型: Article,,卷期:2012年86-4]
- It is known that respiratory syncytial virus (RSV) is the main cause of bronchiolitis and pneumonia in young children. RSV infection often leads to severe acute lung immunopathology, but the underlying immune mechanisms ...
- The Tetherin/BST-2 Coiled-Coil Ectodomain Mediates Plasma Membrane Microdomain Localization and Restriction of Particle Release
[作者:Hammonds, J; Ding, L; Chu, H; Geller, K; Robbins, A; Wang, JJ; Yi, H; Spearman, P,期刊:Journal of virology, 页码:2259-2272 , 文章类型: Article,,卷期:2012年86-4]
- Tetherin/BST-2 forms a proteinaceous tether that restricts the release of a number of enveloped viruses following viral budding. Tetherin is an unusual membrane glycoprotein with two membrane anchors and an extended coil...
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