- On the inhibition of histone deacetylase 8
[作者:ESTIU GUILLERMINA; WEST NATHAN; MAZITSCHEK RALPH; GREENBERG EDWARD; BRADNER JAMES E; WIEST OLAF,期刊:Bioorganic & Medicinal Chemistry, 页码:4103-4110 , 文章类型: Article,,卷期:2010年18-11]
- Histone deacetylases are key regulators of gene expression and have recently emerged as important therapeutic targets for cancer and a growing number of non-malignant diseases. Many widely studied inhibitors of HDACs suc...
- Total synthesis of (+)-crocacin C
[作者:SIRASANI GOPAL; PAUL TAPAS; ANDRADE RODRIGO B,期刊:Bioorganic & Medicinal Chemistry, 页码:3648-3655 , 文章类型: Article,,卷期:2010年18-11]
- Two approaches toward the total synthesis of cytotoxic polyketide natural product (+)-crocacin C (1) are described. The first approach, which was ultimately unsuccessful, was replaced altogether with a second that afford...
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