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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共63条记录   Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin [作者：ISHII TAKESHI; MORI TAIKI; ICHIKAWA TATSUYA; KAKU MAIKO; KUSAKA KOJI; UEKUSA YOSHINORI; AKAGAWA MITSUGU; AIHARA YOSHIYUKI; FURUTA TAKUMI; WAKIMOTO TOSHIYUKI; KAN TOSHIYUKI; NAKAYAMA TSUTOMU,期刊：Bioorganic & Medicinal Chemistry, 页码：4892-4896 , 文章类型： Article，,卷期：2010年18-14] Catechins are polyphenolic antioxidants found in green tea leaves. Recent studies have reported that various polyphenolic compounds, including catechins, cause protein carbonyl formation in proteins via their pro-oxidant... Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor [作者：CHEN CHAONAN; CHEN QIONG; LIU YUCHAO; ZHU XIAOLEI; NIU CONGWEI; XI ZHEN; YANG GUANGFU,期刊：Bioorganic & Medicinal Chemistry, 页码：4897-4904 , 文章类型： Article，,卷期：2010年18-14] The triazolopyrimidine-2-sulfonanilide, discovered from preparing bioisosteres of the sulfonylurea herbicides, is an important class of acetohydroxyacid synthase (AHAS, EC 4.1.3.18) inhibitors. At least over ten triazolo... Synthesis and characterization of selective dopamine D-2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626 [作者：VANGVERAVONG SUWANNA; TAYLOR MICHELLE; XU JINBIN; CUI JINQUAN; CALVIN WESLEY; BABIC SONJA; LUEDTKE ROBERT R; MACH ROBERT H,期刊：Bioorganic & Medicinal Chemistry, 页码：5291-5300 , 文章类型： Article，,卷期：2010年18-14] A series of indole, 7-azaindole, benzofuran, and benzothiophene compounds have been prepared and evaluated for affinity at D2-like dopamine receptors. These compounds share structural elements with the classical D2-like ... Development and evaluation of a Ga-68 labeled pamoic acid derivative for in vivo visualization of necrosis using positron emission tomography [作者：PRINSEN KRISTOF; LI JUNJIE; VANBILLOEN HUBERT; VERMAELEN PETER; DEVOS ELLEN; MORTELMANS LUC; BORMANS GUY; NI YICHENG; VERBRUGGEN ALFONS,期刊：Bioorganic & Medicinal Chemistry, 页码：5274-5281 , 文章类型： Article，,卷期：2010年18-14] In this study, we labeled N, N'-bis(diethylenetriamine pentaacetic acid)-pamoic acid bis-hydrazide (bis-DTPA- PA) with the generator produced PET radionuclide gallium-68 and evaluated Ga-68-bis-DTPA-PA as a potential tra... Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists [作者：IVACHTCHENKO ALEXANDRE V; GOLOVINA ELENA S; KADIEVA MADINA G; KORYAKOVA ANGELA G; KOVALENKO SERGIY M; MITKIN OLEG D; OKUN ILYA M; RAVNYEYKO IRINA M; TKACHENKO SERGEY E; ZAREMBA OLEG V,期刊：Bioorganic & Medicinal Chemistry, 页码：5282-5290 , 文章类型： Article，,卷期：2010年18-14] A number of 3-(phenylsulfonyl) thieno[2,3-e][1,2,3] triazolo[1,5-a] pyrimidines were prepared and their 5HT6 receptor binding affinity and ability to inhibit the functional cellular responses to serotonin were evaluated.... 2-Phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: Synthesis and pharmacological evaluation [作者：DETTMANN SANDRA; SZYMANOWITZ KATRIN; WELLNER ANJA; SCHIEDEL ANKE; MUELLER CHRISTA E; GUST RONALD,期刊：Bioorganic & Medicinal Chemistry, 页码：4905-4916 , 文章类型： Article，,卷期：2010年18-14] 2-Phenyl-1H-benzimidazoles 7a-e were synthesized and tested for gene activation on ERa-positive MCF-7 breast cancer cells, stably transfected with the reporter plasmid ERE(wtc)luc (MCF-7-2a cells). None of the compounds ... Development of chemical probes: Toward the mode of action of a methylene-linked di(aryl acetate) E1 [作者：SMITH MARK E B; GUNN RICHARD M; ROSIVATZ EVELYN; MAK LOK H; WOSCHOLSKI RUEDIGER; HAILES HELEN C,期刊：Bioorganic & Medicinal Chemistry, 页码：4917-4927 , 文章类型： Article，,卷期：2010年18-14] Analogues of the novel inhibitor of the PI3-K/PKB pathway, 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate (E1), have been prepared and preliminary SAR performed. This established that at least on... Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors [作者：BOVA FLORIANA; ETTARI ROBERTA; MICALE NICOLA; CARNOVALE CATERINA; SCHIRMEISTER TANJA; GELHAUS CHRISTOPH; LEIPPE MATTHIAS; GRASSO SILVANA; ZAPPALA MARIA,期刊：Bioorganic & Medicinal Chemistry, 页码：4928-4938 , 文章类型： Article，,卷期：2010年18-14] Herein we report the synthesis of a series of novel constrained peptidomimetics 2-10 endowed with a dipeptide backbone (D-Ser-Gly) and a vinyl ester warhead, structurally related to a previously identified lead compound ... Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides [作者：ABORAIA AHMED S; YEE SOOK WAH; GOMAA MOHAMED SAYED; SHAH NIKHIL; ROBOTHAM ANNA C; MAKOWSKI BART; PROSSER DAVID; BRANCALE ANDREA; JONES GLENVILLE; SIMONS CLAIRE,期刊：Bioorganic & Medicinal Chemistry, 页码：4939-4946 , 文章类型： Article，,卷期：2010年18-14] A series of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides were prepared, using an efficient three-to five-step synthesis, and evaluated for their inhibitory activity against human cytochrome P450C24A1 (CYP24A1) hydrox... Synthesis and cytotoxic activity of a new potential DNA bisintercalator: 1,4-Bis{3-[N-(4-chlorobenzo[g]phthalazin-1-yl)aminopropyl]}piperazine [作者：GALISTEO JUAN; NAVARRO PILAR; CAMPAYO LUCRECIA; YUNTA MARIA J R; GOMEZCONTRERAS FERNANDO; VILLAPULGARIN JANNY A; SIERRA BEATRIZ G; MOLLINEDO FAUSTINO; GONZALEZ JORGE; GARCIAESPANA ENRIQUE,期刊：Bioorganic & Medicinal Chemistry, 页码：5301-5309 , 文章类型： Article，,卷期：2010年18-14] The synthesis of new 1,4-bisalkylamino (2-4) and 1-alkylamino-4-chloro (5-6) substituted benzo[g]phthalazines is reported. Compounds 2-4 and 6 were prepared both in the free and heteroaromatic ring protonated forms. Bifu... Terpioside B, a difucosyl GSL from the marine sponge Terpios sp is a potent inhibitor of NO release [作者：COSTANTINO VALERIA; FATTORUSSO ERNESTO; MANGONI ALFONSO; TETA ROBERTA; PANZA ELISABETTA; IANARO ANGELA,期刊：Bioorganic & Medicinal Chemistry, 页码：5310-5315 , 文章类型： Article，,卷期：2010年18-14] Terpioside B (2a), a unique glycolipid containing two fucose residues in the furanose form in its pentasaccharide chain, was isolated from the marine sponge Terpios sp. Its complete stereostructure was solved by interpre... Novel anti-viability ceramide analogs: Design, synthesis, and structure-activity relationship studies of substituted (S)-2-(benzylideneamino)-3-hydroxy-N-tetradecylpropanamides [作者：LIU JIAWANG; ANTOON JAMES W; PONNAPAKKAM ADHARSH; BECKMAN BARBARA S; FOROOZESH MARYAM,期刊：Bioorganic & Medicinal Chemistry, 页码：5316-5322 , 文章类型： Article，,卷期：2010年18-14] A group of novel L-serinamides, substituted (S)-2-(benzylideneamino)-3-hydroxy-N-tetradecylpropanamides (3a-o) and substituted (S)-2-(benzylamino)-3-hydroxy-N-tetradecyl propanamides (4c, 4i, 4l, and 4o), were synthesize... Development of tryptase inhibitors derived from thalidomide [作者：TETSUHASHI MASASHI; ISHIKAWA MINORU; HASHIMOTO MARIKO; HASHIMOTO YUICHI; AOYAMA HIROSHI,期刊：Bioorganic & Medicinal Chemistry, 页码：5323-5338 , 文章类型： Article，,卷期：2010年18-14] A novel series of tryptase inhibitors with a N-phenylphthalimide skeleton structurally derived from thalidomide (1) has been developed. Structure-activity relationship studies led to a potent and selective tryptase inhib... Synthesis of 5-deoxy-beta-D-galactofuranosides as tools for the characterization of beta-D-galactofuranosidases [作者：BORDONI ANDREA; DE LEDERKREMER ROSA M; MARINO CARLA,期刊：Bioorganic & Medicinal Chemistry, 页码：5339-5345 , 文章类型： Article，,卷期：2010年18-14] Derivatives of 5-deoxy-beta-D-galactofuranose (5-deoxy-alpha-L-arabino-hexofuranose) have been synthesized starting from D-galacturonic acid. The synthesis of methyl 5-deoxy-alpha-L-arabino-hexofuranoside (14 alpha) was ... Discovery of potent and orally active tricyclic-based FBPase inhibitors [作者：TSUKADA TOMOHARU; KANNO OSAMU; YAMANE TAKAHIRO; TANAKA JUN; YOSHIDA TAISHI; OKUNO AKIRA; SHIIKI TAKESHI; TAKAHASHI MIZUKI; NISHI TAKAHIDE,期刊：Bioorganic & Medicinal Chemistry, 页码：5346-5351 , 文章类型： Article，,卷期：2010年18-14] With the aim of exploring the effect of tricyclic-based FBPase inhibitors in cells and in vivo, a series of prodrugs of tricyclic phosphonates was designed and synthesized. Introducing prodrug moieties into tricyclic-bas... Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer [作者：SUN BIN; HOSHINO JUMA; JERMIHOV KATIE; MARLER LAURA; PEZZUTO JOHN M; MESECAR ANDREW D; CUSHMAN MARK,期刊：Bioorganic & Medicinal Chemistry, 页码：5352-5366 , 文章类型： Article，,卷期：2010年18-14] A series of new resveratrol analogues were designed and synthesized and their inhibitory activities against aromatase were evaluated. The crystal structure of human aromatase (PDB 3eqm) was used to rationalize the mechan...