- Resistance Mutations in Human Immunodeficiency Virus Type 1 Integrase Selected with Elvitegravir Confer Reduced Susceptibility to a Wide Range of Integrase Inhibitors
[作者:Goethals, O; Clayton, R; Van Ginderen, M; Vereycken, I; Wagemans, E; Geluykens, P; Dockx, K; Strijbos, R; Smits, V; Vos, A; Meersseman, G; Jochmans, D; Vermeire, K; Schols, D; Hallenberger, S; Hertogs, K,期刊:Journal of virology, 页码:10366-10374 , 文章类型: Article,,卷期:2008年82-21]
- Integration of viral DNA into the host chromosome is an essential step in the life cycle of retroviruses and is facilitated by the viral integrase enzyme. The first generation of integrase inhibitors recently approved or...
- Detecting Small Changes and Additional Peptides in the Canine Parvovirus Capsid Structure
[作者:Nelson, CDS; Minkkinen, E; Bergkvist, M; Hoelzer, K; Fisher, M; Bothner, B; Parrish, CR,期刊:Journal of virology, 页码:10397-10407 , 文章类型: Article,,卷期:2008年82-21]
- Parvovirus capsids are assembled from multiple forms of a single protein and are quite stable structurally. However, in order to infect cells, conformational plasticity of the capsid is required and this likely involves ...
- Hepatitis C Virus Infection Induces Apoptosis through a Bax-Triggered, Mitochondrion-Mediated, Caspase 3-Dependent Pathway
[作者:Deng, L; Adachi, T; Kitayama, K; Bungyoku, Y; Kitazawa, S; Ishido, S; Shoji, I; Hotta, H,期刊:Journal of virology, 页码:10375-10385 , 文章类型: Article,,卷期:2008年82-21]
- We previously reported that cells harboring the hepatitis C virus (HCV) RNA replicon as well as those expressing HCV NS3/4A exhibited increased sensitivity to suboptimal doses of apoptotic stimuli to undergo mitochondrio...
- Three-Dimensional Organization of Rift Valley Fever Virus Revealed by Cryoelectron Tomography
[作者:Freiberg, AN; Sherman, MB; Morais, MC; Holbrook, MR; Watowich, SJ,期刊:Journal of virology, 页码:10341-10348 , 文章类型: Article,,卷期:2008年82-21]
- Rift Valley fever virus (RVFV) is a member of the Bunyaviridae virus family ( genus Phlebovirus) and is considered to be one of the most important pathogens in Africa, causing viral zoonoses in livestock and humans. Here...
- Growth Determinants for H5N1 Influenza Vaccine Seed Viruses in MDCK Cells
[作者:Murakami, S; Horimoto, T; Mai, LQ; Nidom, CA; Chen, H; Muramoto, Y; Yamada, S; Iwasa, A; Iwatsuki-Horimoto, K; Shimojima, M; Iwata, A; Kawaoka, Y,期刊:Journal of virology, 页码:10502-10509 , 文章类型: Article,,卷期:2008年82-21]
- H5N1 influenza A viruses are exacting a growing human toll, with more than 240 fatal cases to date. In the event of an influenza pandemic caused by these viruses, embryonated chicken eggs, which are the approved substrat...
- A Dynamic View of Hepatitis C Virus Replication Complexes
[作者:Wolk, B; Buchele, B; Moradpour, D; Rice, CM,期刊:Journal of virology, 页码:10519-10531 , 文章类型: Article,,卷期:2008年82-21]
- Hepatitis C virus (HCV) replicates its genome in a membrane-associated replication complex ( RC). Specific membrane alterations, designated membranous webs, represent predominant sites of HCV RNA replication. The princip...
- Lentivirus Vector Can Be Readministered to Nasal Epithelia without Blocking Immune Responses
[作者:Sinn, PL; Arias, AC; Brogden, KA; McCray, PB,期刊:Journal of virology, 页码:10684-10692 , 文章类型: Article,,卷期:2008年82-21]
- For many envisioned applications of lentivirus vectors as tools in respiratory biology and therapeutic gene delivery, the efficiency of gene transfer must be improved. We previously demonstrated stable, persistent (>11 m...
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