- NF-kappa B Signaling Differentially Regulates Influenza Virus RNA Synthesis
[作者:Kumar, N; Xin, ZT; Liang, YH; Ly, H; Liang, YY,期刊:Journal of virology, 页码:9880-9889 , 文章类型: Article,,卷期:2008年82-20]
The NF-kB signaling pathway has previously been shown to be required for efficient influenza A virus replication, although the molecular mechanism is not well understood. In this study, we identified a specific step o...
- CD20, CD3, and CD40 Ligand Microclusters Segregate Three-Dimensionally In Vivo at B-Cell-T-Cell Immunological Synapses after Viral Immunity in Primate Brain
[作者:Barcia, C; Gomez, A; de Pablos, V; Fernandez-Villalba, E; Liu, CY; Kroeger, KM; Martin, J; Barreiro, AF; Castro, MG; Lowenstein, PR; Herrero, MT,期刊:Journal of virology, 页码:9978-9993 , 文章类型: Article,,卷期:2008年82-20]
- The clearance of virally infected cells from the brain is mediated by T cells that engage antigen-presenting cells to form supramolecular activation clusters at the immunological synapse. However, after clearance, the T ...
- Scrapie-Induced Defects in Learning and Memory of Transgenic Mice Expressing Anchorless Prion Protein Are Associated with Alterations in the Gamma Aminobutyric Acid-Ergic Pathway
[作者:Trifilo, MJ; Sanchez-Alavez, M; Solforosi, L; Bernard-Trifilo, J; Kunz, S; McGavern, D; Oldstone, MBA,期刊:Journal of virology, 页码:9890-9899 , 文章类型: Article,,卷期:2008年82-20]
- After infection with RML murine scrapie agent, transgenic (tg) mice expressing prion protein (PrP) without its glycophosphatidylinositol (GPI) membrane anchor (GPI(-/)-PrP tg mice) continue to make abundant amounts of th...
- Human Endogenous Retrovirus Family HERV-K(HML-2) RNA Transcripts Are Selectively Packaged into Retroviral Particles Produced by the Human Germ Cell Tumor Line Tera-1 and Originate Mainly from a Provirus on Chromosome 22q11.21
[作者:Ruprecht, K; Ferreira, H; Flockerzi, A; Wahl, S; Sauter, M; Mayer, J; Mueller-Lantzsch, N,期刊:Journal of virology, 页码:10008-10016 , 文章类型: Article,,卷期:2008年82-20]
- The human germ cell tumor line Tera-1 produces retroviral particles which are encoded by the human endogenous retrovirus family HERV-K(HML-2). We show here, by quantitative reverse transcriptase PCR, that HML-2 gag and e...
- Impaired Hepatitis C Virus (HCV)-Specific Effector CD8(+) T Cells Undergo Massive Apoptosis in the Peripheral Blood during Acute HCV Infection and in the Liver during the Chronic Phase of Infection
[作者:Radziewicz, H; Ibegbu, CC; Hon, HM; Osborn, MK; Obideen, K; Wehbi, M; Freeman, GJ; Lennox, JL; Workowski, KA; Hanson, HL; Grakoui, A,期刊:Journal of virology, 页码:9808-9822 , 文章类型: Article,,卷期:2008年82-20]
- A majority of patients infected with hepatitis C virus (HCV) do not sustain an effective T-cell response, and viremia persists. The mechanism leading to failure of the HCV-specific CD8(+) T-cell response in patients deve...
- Evolutionarily Conserved Function of a Viral MicroRNA
[作者:Seo, GJ; Fink, LHL; O'Hara, B; Atwood, WJ; Sullivan, CS,期刊:Journal of virology, 页码:9823-9828 , 文章类型: Article,,卷期:2008年82-20]
- MicroRNAs (miRNAs) are potent RNA regulators of gene expression. Some viruses encode miRNAs, most of unknown function. The majority of viral miRNAs are not conserved, and whether any have conserved functions remains uncl...
- Transactivation of Cellular Genes Involved in Nucleotide Metabolism by the Regulatory IE1 Protein of Murine Cytomegalovirus Is Not Critical for Viral Replicative Fitness in Quiescent Cells and Host Tissues
[作者:Wilhelmi, V; Simon, CO; Podlech, J; Bohm, V; Daubner, T; Emde, S; Strand, D; Renzaho, A; Lemmermann, NAW; Seckert, CK; Reddehase, MJ; Grzimek, NKA,期刊:Journal of virology, 页码:9900-9916 , 文章类型: Article,,卷期:2008年82-20]
- Despite its high coding capacity, murine CMV (mCMV) does not encode functional enzymes for nucleotide biosynthesis. It thus depends on cellular enzymes, such as ribonucleotide reductase (RNR) and thymidylate synthase (TS...
- Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8(+) Memory T Cells
[作者:Badr, G; Bedard, N; Abdel-Hakeem, MS; Trautmann, L; Willems, B; Villeneuve, JP; Haddad, EK; Sekaly, RP; Bruneau, J; Shoukry, NH,期刊:Journal of virology, 页码:10017-10031 , 文章类型: Article,,卷期:2008年82-20]
- The majority of acute hepatitis C virus (HCV) infections progress to chronicity and progressive liver damage. Alpha interferon (IFN-alpha) antiviral therapy achieves the highest rate of success when IFN-alpha is administ...
- Ectromelia Virus Encodes a Novel Family of F-Box Proteins That Interact with the SCF Complex
[作者:van Buuren, N; Couturier, B; Xiong, Y; Barry, M,期刊:Journal of virology, 页码:9917-9927 , 文章类型: Article,,卷期:2008年82-20]
- Poxviruses are notorious for encoding multiple proteins that regulate cellular signaling pathways, including the ubiquitin-proteasome system. Bioinformatics indicated that ectromelia virus, the causative agent of lethal ...
- Human Immunodeficiency Virus Type 1 Replication and Regulation of APOBEC3G by Peptidyl Prolyl Isomerase Pin1
[作者:Watashi, K; Khan, M; Yedavalli, VRK; Yeung, ML; Strebel, K; Jeang, KT,期刊:Journal of virology, 页码:9928-9936 , 文章类型: Article,,卷期:2008年82-20]
- APOBEC3G (A3G) is a cytidine deaminase that restricts human immunodeficiency virus type 1 (HIV-1) replication. HIV-1 synthesizes a viral infectivity factor (Vif) to counter A3G restriction. Currently, it is poorly unders...
- Small-Ruminant Lentivirus Enhances PrPSc Accumulation in Cultured Sheep Microglial Cells
[作者:Stanton, JB; Knowles, DP; O'Rourke, KI; Herrmann-Hoesing, LM; Mathison, BA; Baszler, TV,期刊:Journal of virology, 页码:9839-9847 , 文章类型: Article,,卷期:2008年82-20]
- Sheep scrapie is the prototypical transmissible spongiform encephalopathy (prion disease), which has a fundamental pathogenesis involving conversion of normal cellular prion protein (PrPC [C superscript stands for cellul...
- Possible Role for Cellular Karyopherins in Regulating Polyomavirus and Papillomavirus Capsid Assembly
[作者:Bird, G; O'Donnell, M; Moroianu, J; Garcea, RL,期刊:Journal of virology, 页码:9848-9857 , 文章类型: Article,,卷期:2008年82-20]
- Polyomavirus and papillomavirus (papovavirus) capsids are composed of 72 capsomeres of their major capsid proteins, VP1 and L1, respectively. After translation in the cytoplasm, L1 and VP1 pentamerize into capsomeres and...
- Kinesin KIF4 Regulates Intracellular Trafficking and Stability of the Human Immunodeficiency Virus Type 1 Gag Polyprotein
[作者:Martinez, NW; Xue, XX; Berro, RG; Kreitzer, G; Resh, MD,期刊:Journal of virology, 页码:9937-9950 , 文章类型: Article,,卷期:2008年82-20]
- Retroviral Gag proteins are synthesized as soluble, myristoylated precursors that traffic to the plasma membrane and promote viral particle production. The intracellular transport of human immunodeficiency virus type 1 (...
- Block to the Production of Full-Length B19 Virus Transcripts by Internal Polyadenylation Is Overcome by Replication of the Viral Genome
[作者:Guan, WX; Cheng, F; Yoto, YK; Kleiboeker, S; Wong, SS; Zhi, N; Pintel, DJ; Qiu, JM,期刊:Journal of virology, 页码:9951-9963 , 文章类型: Article,,卷期:2008年82-20]
- The pre-mRNA processing strategy of the B19 virus is unique among parvoviruses. B19 virus-generated pre-mRNAs are transcribed from a single promoter and are extensively processed by alternative splicing and alternative p...
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