- Abrogation of E-Cadherin-Mediated Cell-Cell Contact in Mouse Embryonic Stem Cells Results in Reversible LIF-Independent Self-Renewal
[作者:Soncin, F; Mohamet, L; Eckardt, D; Ritson, S; Eastham, AM; Bobola, N; Russell, A; Davies, S; Kemler, R; Merry, CLR; Ward, CM,期刊:Stem Cells, 页码:2069-2080 , 文章类型: Article,,卷期:2009年27-9]
- We have previously demonstrated that differentiation of embryonic stem (ES) cells is associated with downregulation of cell surface E-cadherin. In this study, we assessed the function of E-cadherin in mouse ES cell pluri...
- Nanog Regulates Proliferation During Early Fish Development
[作者:Camp, E; Sanchez-Sanchez, AV; Garcia-Espana, A; DeSalle, R; Odqvist, L; O'Connor, JE; Mullor, JL,期刊:Stem Cells, 页码:2081-2091 , 文章类型: Article,,卷期:2009年27-9]
- Nanog is involved in controlling pluripotency and differentiation of stem cells in vitro. However, its function in vivo has been studied only in mouse embryos and various reports suggest that Nanog may not be required fo...
- Cell Adhesion and Spreading Affect Adipogenesis from Embryonic Stem Cells: The Role of Calreticulin
[作者:Szabo, E; Feng, TS; Dziak, E; Opas, M,期刊:Stem Cells, 页码:2092-2102 , 文章类型: Article,,卷期:2009年27-9]
- Calreticulin is an endoplasmic reticulum-resident multifunctional protein, which has been shown to influence numerous cellular processes, including cell adhesion. In this study, we characterized the adhesive properties o...
- Generation of Monoclonal Antibodies Specific for Cell Surface Molecules Expressed on Early Mouse Endoderm
[作者:Gadue, P; Gouon-Evans, V; Cheng, X; Wandzioch, E; Zaret, KS; Grompe, M; Streeter, PR; Keller, GM,期刊:Stem Cells, 页码:2103-2113 , 文章类型: Article,,卷期:2009年27-9]
- The development of functional cell populations such as hepatocytes and pancreatic beta cells from embryonic stem cell (ESC) is dependent on the efficient induction of definitive endoderm early in the differentiation proc...
- KLF4 and PBX1 Directly Regulate NANOG Expression in Human Embryonic Stem Cells
[作者:Chan, KKK; Zhang, J; Chia, NY; Chan, YS; Sim, HS; Tan, KS; Oh, SKW; Ng, HH; Choo, ABH,期刊:Stem Cells, 页码:2114-2125 , 文章类型: Article,,卷期:2009年27-9]
- Insight into the regulation of core transcription factors is important for a better understanding of the molecular mechanisms that control self-renewal and pluripotency of human ESCs (hESCs). However, the transcriptional...
- Long-Term Safety and Function of RPE from Human Embryonic Stem Cells in Preclinical Models of Macular Degeneration
[作者:Lu, B; Malcuit, C; Wang, SM; Girman, S; Francis, P; Lemieux, L; Lanza, R; Lund, R,期刊:Stem Cells, 页码:2126-2135 , 文章类型: Article,,卷期:2009年27-9]
- Assessments of safety and efficacy are crucial before human ESC (hESC) therapies can move into the clinic. Two important early potential hESC applications are the use of retinal pigment epithelium (RPE) for the treatment...
- Birth of Parthenote Mice Directly from Parthenogenetic Embryonic Stem Cells
[作者:Chen, ZS; Liu, Z; Huang, JJ; Amano, T; Li, C; Cao, SB; Wu, C; Liu, BD; Zhou, LJ; Carter, MG; Keefe, DL; Yang, XZ; Liu, L,期刊:Stem Cells, 页码:2136-2145 , 文章类型: Article,,卷期:2009年27-9]
- Mammalian parthenogenetic embryos are not viable and die because of defects in placental development and genomic imprinting. Parthenogenetic ESCs (pESCs) derived from parthenogenetic embryos might advance regenerative me...
- Noggin Elicits Retinal Fate in Xenopus Animal Cap Embryonic Stem Cells
[作者:Lan, L; Vitobello, A; Bertacchi, M; Cremisi, F; Vignali, R; Andreazzoli, M; Demontis, GC; Barsacchi, G; Casarosa, S,期刊:Stem Cells, 页码:2146-2152 , 文章类型: Article,,卷期:2009年27-9]
- Driving specific differentiation pathways in multipotent stem cells is a main goal of cell therapy. Here we exploited the differentiating potential of Xenopus animal cap embryonic stem (ACES) cells to investigate the fac...
- Gfi-1B Promoter Remains Associated with Active Chromatin Marks Throughout Erythroid Differentiation of Human Primary Progenitor Cells
[作者:Laurent, B; Randrianarison-Huetz, V; Kadri, Z; Romeo, PH; Porteu, F; Dumenil, D,期刊:Stem Cells, 页码:2153-2162 , 文章类型: Article,,卷期:2009年27-9]
- Growth Factor Independent-1B (Gfi-1B) is a transcriptional repressor that plays critical roles in the control of erythropoiesis and megakaryopoiesis. Gfi-1B expression was described to be repressed by an autoregulatory f...
- Global Expression Profile of Highly Enriched Cardiomyocytes Derived from Human Embryonic Stem Cells
[作者:Xu, XQ; Soo, SY; Sun, W; Zweigerdt, R,期刊:Stem Cells, 页码:2163-2174 , 文章类型: Article,,卷期:2009年27-9]
- Human embryonic stem cells (hESC), with their ability to differentiate into cardiomyocytes in culture, hold great potential for cell replacement therapies and provide an in vitro model of human heart development. A genom...
- Acetylation of Sox2 Induces Its Nuclear Export in Embryonic Stem Cells
[作者:Baltus, GA; Kowalski, MP; Zhai, H; Tutter, AV; Quinn, D; Wall, D; Kadam, S,期刊:Stem Cells, 页码:2175-2184 , 文章类型: Article,,卷期:2009年27-9]
- Embryonic stem (ES) cells require a coordinated network of transcription factors to maintain pluripotency or trigger lineage specific differentiation. Central to these processes are the proteins Oct4, Nanog, and Sox2. Al...
- Endothelial Cells Support Survival, Proliferation, and Neuronal Differentiation of Transplanted Adult Ischemia-Induced Neural Stem/Progenitor Cells After Cerebral Infarction
[作者:Nakagomi, N; Nakagomi, T; Kubo, S; Nakano-Doi, A; Saino, O; Takata, M; Yoshikawa, H; Stern, DM; Matsuyama, T; Taguchi, A,期刊:Stem Cells, 页码:2185-2195 , 文章类型: Article,,卷期:2009年27-9]
- Transplantation of neural stem cells (NSCs) has been proposed as a therapy for a range of neurological disorders. To realize the potential of this approach, it is essential to control survival, proliferation, migration, ...
- Identification of Nonepithelial Multipotent Cells in the Embryonic Olfactory Mucosa
[作者:Tome, M; Lindsay, SL; Riddell, JS; Barnett, SC,期刊:Stem Cells, 页码:2196-2208 , 文章类型: Article,,卷期:2009年27-9]
- Olfactory mucosal (OM) tissue, a potential source of stem cells, is currently being assessed in the clinic as a candidate tissue for transplant-mediated repair of spinal cord injury. We examined the ability of embryonic ...
- Circulating Osteogenic Precursor Cells in Heterotopic Bone Formation
[作者:Suda, RK; Billings, PC; Egan, KP; Kim, JH; McCarrick-Walmsley, R; Glaser, DL; Porter, DL; Shore, EM; Pignolo, RJ,期刊:Stem Cells, 页码:2209-2219 , 文章类型: Article,,卷期:2009年27-9]
- Cells with osteogenic potential can be found in a variety of tissues. Here we show that circulating osteogenic precursor (COP) cells, a bone marrow-derived type I collagen(+)/CD45(+) subpopulation of mononuclear adherent...
- High Aldehyde Dehydrogenase Activity: A Novel Functional Marker of Murine Prostate Stem/Progenitor Cells
[作者:Burger, PE; Gupta, R; Xiong, X; Ontiveros, CS; Salm, SN; Moscatelli, D; Wilson, EL,期刊:Stem Cells, 页码:2220-2228 , 文章类型: Article,,卷期:2009年27-9]
- We have shown previously that prostatic stem/progenitor cells can be purified from isolated prostate ducts, based on their high expression of the Sca-1 surface antigen. We now report that high levels of aldehyde dehydrog...
- Implanted Adult Human Dental Pulp Stem Cells Induce Endogenous Axon Guidance
[作者:Arthur, A; Shi, ST; Zannettino, ACW; Fujii, N; Gronthos, S; Koblar, SA,期刊:Stem Cells, 页码:2229-2237 , 文章类型: Article,,卷期:2009年27-9]
- The human central nervous system has limited capacity for regeneration. Stem cell-based therapies may overcome this through cellular mechanisms of neural replacement and/or through molecular mechanisms, whereby secreted ...
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