- SOX15 and SOX7 Differentially Regulate the Myogenic Program in P19 Cells
[作者:Savage, J; Conley, AJ; Blais, A; Skerjanc, IS,期刊:Stem Cells, 页码:1231-1243 , 文章类型: Article,,卷期:2009年27-6]
- In this study, we have identified novel roles for Sox15 and Sox7 as regulators of muscle precursor cell fate in P19 cells. To examine the role of Sox15 and Sox7 during skeletal myogenesis, we isolated populations of P19 ...
- Ly-1 Antibody Reactive Clone Is an Important Nucleolar Protein for Control of Self-Renewal and Differentiation in Embryonic Stem Cells
[作者:Li, H; Wang, BB; Yang, A; Lu, R; Wang, WC; Zhou, Y; Shi, GL; Kwon, SW; Zhao, YM; Jin, Y,期刊:Stem Cells, 页码:1244-1254 , 文章类型: Article,,卷期:2009年27-6]
- Embryonic stem cells (ESCs) possess the capacity to self-renew and differentiate into all cell types of an organism. It is essential to understand how these properties are controlled for the potential usage of their deri...
- Epigenetic Reprogramming by Somatic Cell Nuclear Transfer in Primates
[作者:Sparman, M; Dighe, V; Sritanaudomchai, H; Ma, H; Ramsey, C; Pedersen, D; Clepper, L; Nighot, P; Wolf, D; Hennebold, J; Mitalipov, S,期刊:Stem Cells, 页码:1255-1264 , 文章类型: Article,,卷期:2009年27-6]
- We recently demonstrated that somatic cells from adult primates could be reprogrammed into a pluripotent state by somatic cell nuclear transfer. However, the low efficiency with donor cells from one monkey necessitated t...
- Alternative Translation of OCT4 by an Internal Ribosome Entry Site and its Novel Function in Stress Response
[作者:Wang, X; Zhao, YN; Xiao, ZF; Chen, B; Wei, ZL; Wang, B; Zhang, J; Han, J; Gao, Y; Li, LS; Zhao, HX; Zhao, WX; Lin, H; Dai, JW,期刊:Stem Cells, 页码:1265-1275 , 文章类型: Article,,卷期:2009年27-6]
- OCT4 is a pivotal transcription factor in maintaining the pluripotency and self-renewal capacities of embryonic stem (ES) cells. Human OCT4 can generate two isoforms by alternative splicing, termed OCT4A and OCT4B. OCT4A...
- Stepwise Differentiation of Human Embryonic Stem Cells Promotes Tendon Regeneration by Secreting Fetal Tendon Matrix and Differentiation Factors
[作者:Chen, X; Song, XH; Yin, Z; Zou, XH; Wang, LL; Hu, H; Cao, T; Zheng, MH; Ouyang, HW,期刊:Stem Cells, 页码:1276-1287 , 文章类型: Article,,卷期:2009年27-6]
- Human embryonic stem cells (hESCs) are ideal seed cells for tissue regeneration, but no research has yet been reported concerning their potential for tendon regeneration. This study investigated the strategy and efficacy...
- Insights into Mesenchymal Stem Cell Aging: Involvement of Antioxidant Defense and Actin Cytoskeleton
[作者:Kasper, G; Mao, L; Geissler, S; Draycheva, A; Trippens, J; Kuhnisch, J; Tschirschmann, M; Kaspar, K; Perka, C; Duda, GN; Klose, J,期刊:Stem Cells, 页码:1288-1297 , 文章类型: Article,,卷期:2009年27-6]
- Progenitor cells such as mesenchymal stem cells (MSCs) have elicited great hopes for therapeutic augmentation of physiological regeneration processes, e. g., for bone fracture healing. However, regeneration potential dec...
- Fibroblast Growth Factor-2 Overexpression in Transplanted Neural Progenitors Promotes Perivascular Cluster Formation with a Neurogenic Potential
[作者:Jenny, B; Kanemitsu, M; Tsupykov, O; Potter, G; Salmon, P; Zgraggen, E; Gascon, E; Skibo, G; Dayer, AG; Kiss, JZ,期刊:Stem Cells, 页码:1309-1317 , 文章类型: Article,,卷期:2009年27-6]
- Stem/progenitor cell-based therapies hold promises for repairing the damaged nervous system. However, the efficiency of these approaches for neuronal replacement remains very limited. A major challenge is to develop pre-...
- Identification of a Stroma-Mediated Wnt/beta-Catenin Signal Promoting Self-Renewal of Hematopoietic Stem Cells in the Stem Cell Niche
[作者:Kim, JA; Kang, YJ; Park, G; Kim, M; Park, YO; Kim, H; Leem, SH; Chu, IS; Lee, JS; Jho, EH; Oh, IH,期刊:Stem Cells, 页码:1318-1329 , 文章类型: Article,,卷期:2009年27-6]
- With contrasting observations on the effects of beta-catenin on hematopoietic stem cells (HSCs), the precise role of Wnt/beta-catenin signals on HSC regulation remains unclear. Here, we show a distinct mode of Wnt/beta-c...
- Activin A Is Essential for Neurogenesis Following Neurodegeneration
[作者:Abdipranoto-Cowley, A; Park, JS; Croucher, D; Daniel, J; Henshall, S; Galbraith, S; Mervin, K; Vissel, B,期刊:Stem Cells, 页码:1330-1346 , 文章类型: Article,,卷期:2009年27-6]
- It has long been proposed that excitotoxicity contributes to nerve cell death in neurodegenerative diseases. Activin A, a member of the transforming growth factor-beta superfamily, is expressed by neurons following excit...
- cAMP Response Element Binding Protein Is Required for Mouse Neural Progenitor Cell Survival and Expansion
[作者:Dworkin, S; Malaterre, J; Hollande, F; Darcy, PK; Ramsay, RG; Mantamadiotis, T,期刊:Stem Cells, 页码:1347-1357 , 文章类型: Article,,卷期:2009年27-6]
- Development of the mammalian brain relies on the coordinated expansion of neural cells in a relatively short time, spanning for a period of only a few days in mice. The molecular networks regulating neural cell birth and...
- Integrin-Linked Kinase Is Required in Hypoxic Mesenchymal Stem Cells for Strengthening Cell Adhesion to Ischemic Myocardium
[作者:Song, SW; Chang, W; Song, BW; Song, H; Lim, S; Kim, HJ; Cha, MJ; Choi, E; Im, SH; Chang, BC; Chung, N; Jang, Y; Hwang, KC,期刊:Stem Cells, 页码:1358-1365 , 文章类型: Article,,卷期:2009年27-6]
- Mesenchymal stem cells (MSCs) therapy has limitations due to the poor viability of MSCs after cell transplantation. Integrin-mediated adhesion is a prerequisite for cell survival. As a novel anti-death strategy to improv...
- Matrix Metalloproteinase 1 Is Necessary for the Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells Toward Human Glioma
[作者:Ho, IAW; Chan, KYW; Ng, WH; Guo, CM; Hui, KM; Cheang, P; Lam, PYP,期刊:Stem Cells, 页码:1366-1375 , 文章类型: Article,,卷期:2009年27-6]
- Human mesenchymal stem cells (MSCs) have increasingly been used as cellular vectors for the delivery of therapeutic genes to tumors. However, the precise mechanism of mobilization remains poorly defined. In this study, M...
- Epithelial Cells Derived from Human Embryonic Stem Cells Display P16(INK4A) Senescence, Hypermotility, and Differentiation Properties Shared by Many P63(+) Somatic Cell Types
[作者:Dabelsteen, S; Hercule, P; Barron, P; Rice, M; Dorsainville, G; Rheinwald, JG,期刊:Stem Cells, 页码:1388-1399 , 文章类型: Article,,卷期:2009年27-6]
- Human embryonic stem (hES) cells can generate cells expressing p63, K14, and involucrin, which have been proposed to be keratinocytes. Although these hES-derived, keratinocyte-like (hESderK) cells form epithelioid coloni...
- Phenotypic and Functional Changes Induced in Hematopoietic Stem/Progenitor Cells After Gamma-Ray Radiation Exposure
[作者:Simonnet, AJ; Nehme, J; Vaigot, P; Barroca, V; Leboulch, P; Tronik-Le Roux, D,期刊:Stem Cells, 页码:1400-1409 , 文章类型: Article,,卷期:2009年27-6]
- Ionizing radiation (IR) exposure causes rapid and acute bone marrow (BM) suppression that is reversible for non-lethal doses. Evidence is accumulating that IR can also provoke long-lasting residual hematopoietic injury. ...
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