- Characterization of the Phosphoinositide 3-Kinase-Dependent Transcriptome in Murine Embryonic Stem Cells: Identification of Novel Regulators of Pluripotency
[作者:Storm, MP; Kumpfmueller, B; Thompson, B; Kolde, R; Vilo, J; Hummel, O; Schulz, H; Welham, MJ,期刊:Stem Cells, 页码:764-775 , 文章类型: Article,,卷期:2009年27-4]
- Phosphoinositide 3-kinase (PI3K)-dependent signaling has been implicated in the regulation of embryonic stem (ES) cell fate. To gain further insight into the mechanisms regulated by PI3Ks in murine ES cells, we have perf...
- Derivation of Primordial Germ Cells from Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved by Coculture with Human Fetal Gonadal Cells
[作者:Park, TS; Galic, Z; Conway, AE; Lindgren, A; van Handel, BJ; Magnusson, M; Richter, L; Teitell, MA; Mikkola, HKA; Lowry, WE; Plath, K; Clark, AT,期刊:Stem Cells, 页码:783-795 , 文章类型: Article,,卷期:2009年27-4]
- The derivation of germ cells from human embryonic stem cells (hESCs) or human induced pluripotent stem (hIPS) cells represents a desirable experimental model and potential strategy for treating infertility. In the curren...
- Sall4 Is Essential for Stabilization, But Not for Pluripotency, of Embryonic Stem Cells by Repressing Aberrant Trophectoderm Gene Expression
[作者:Yuri, S; Fujimura, S; Nimura, K; Takeda, N; Toyooka, Y; Fujimura, YI; Aburatani, H; Ura, K; Koseki, H; Niwa, H; Nishinakamura, R,期刊:Stem Cells, 页码:796-805 , 文章类型: Article,,卷期:2009年27-4]
- Sall4 is a mouse homolog of a causative gene of the autosomal dominant disorder Okihiro syndrome. We previously showed that the absence of Sall4 leads to lethality during peri-implantation and that Sall4-null embryonic s...
- Directed Differentiation of Human-Induced Pluripotent Stem Cells Generates Active Motor Neurons
[作者:Karumbayaram, S; Novitch, BG; Patterson, M; Umbach, JA; Richter, L; Lindgren, A; Conway, AE; Clark, AT; Goldman, SA; Plath, K; Wiedau-Pazos, M; Kornblum, HI; Lowry, WE,期刊:Stem Cells, 页码:806-811 , 文章类型: Article,,卷期:2009年27-4]
- The potential for directed differentiation of human-induced pluripotent stem (iPS) cells to functional postmitotic neuronal phenotypes is unknown. Following methods shown to be effective at generating motor neurons from ...
- Molecular Characterization of the Human NANOG Protein
[作者:Chang, DF; Tsai, SC; Wang, XC; Xia, P; Senadheera, D; Lutzko, C,期刊:Stem Cells, 页码:812-821 , 文章类型: Article,,卷期:2009年27-4]
- NANOG is a key transcriptional regulator of pluripotent stem cell (PSC) self-renewal. NANOG occupies promoters that are active and others that are repressed during self-renewal; however, the mechanisms by which NANOG reg...
- DNA Methylation-Associated Repression of Cancer-Germline Genes in Human Embryonic and Adult Stem Cells
[作者:Loriot, A; Reister, S; Parvizi, GK; Lysy, PA; De Smet, C,期刊:Stem Cells, 页码:822-824 , 文章类型: Article,,卷期:2009年27-4]
- Cancer-germline (CG) genes are a particular group of germline-specific genes that rely primarily on DNA methylation for repression in somatic tissues. In a wide variety of tumors, the promoter of these genes is demethyla...
- Human Cord Blood CD133(+) Stem Cells Transplanted to Nod-Scid Mice Provide Conditions for Regeneration of Olfactory Neuroepithelium After Permanent Damage Induced by Dichlobenil
[作者:Franceschini, V; Bettini, S; Pifferi, S; Rosellini, A; Menini, A; Saccardi, R; Ognio, E; Jeffery, R; Poulsom, R; Revoltella, RP,期刊:Stem Cells, 页码:825-835 , 文章类型: Article,,卷期:2009年27-4]
- The herbicide dichlobenil selectively causes necrosis of the dorsomedial part of olfactory neuroepithelium (NE) with permanent damage to the underlying mucosa, whereas the lateral part of the olfactory region and the nas...
- Concurrent Blockade of alpha 4-Integrin and CXCR4 in Hematopoietic Stem/Progenitor Cell Mobilization
[作者:Bonig, H; Watts, KL; Chang, KH; Kiem, HP; Papayannopoulou, T,期刊:Stem Cells, 页码:836-837 , 文章类型: Article,,卷期:2009年27-4]
- The important contributions of the alpha 4 integrin VLA-4 and the CXCR4/SDF-1 axis in mobilization have been demonstrated and thereby, these pathways can be suggested as rational targets for clinical stem cell mobilizati...
- Blood-Brain Barrier Promotes Differentiation of Human Fetal Neural Precursor Cells
[作者:Chintawar, S; Cayrol, R; Antel, J; Pandolfo, M; Prat, A,期刊:Stem Cells, 页码:838-846 , 文章类型: Article,,卷期:2009年27-4]
- In the stem cell niche, neural stem cells (NSCs) are in close contact with the specialized blood-brain barrier (BBB) endothelial cells (ECs) that modulate their proliferation and differentiation behavior. NSCs are also a...
- Engineering of Dominant Active Basic Helix-Loop-Helix Proteins That Are Resistant to Negative Regulation by Postnatal Central Nervous System Antineurogenic Cues
[作者:Geoffroy, CG; Critchley, JA; Castro, DS; Ramelli, S; Barraclough, C; Descombes, P; Guillemot, F; Raineteau, O,期刊:Stem Cells, 页码:847-856 , 文章类型: Article,,卷期:2009年27-4]
- Neural precursor cells (NPCs) are present in most regions of the adult central nervous system (CNS). Using NPCs in a therapeutical perspective, that is, to regenerate CNS tissue after injury or in neurodegenerative disea...
- Stem Cell Property of Postmigratory Cranial Neural Crest Cells and Their Utility in Alveolar Bone Regeneration and Tooth Development
[作者:Chung, IH; Yamaza, T; Zhao, H; Choung, PH; Shi, S; Chai, Y,期刊:Stem Cells, 页码:866-877 , 文章类型: Article,,卷期:2009年27-4]
- The vertebrate neural crest is a multipotent cell population that gives rise to a variety of different cell types. We have discovered that postmigratory cranial neural crest cells (CNCCs) maintain mesenchymal stem cell c...
- Intra-articular Injected Synovial Stem Cells Differentiate into Meniscal Cells Directly and Promote Meniscal Regeneration Without Mobilization to Distant Organs in Rat Massive Meniscal Defect
[作者:Horie, M; Sekiya, I; Muneta, T; Ichinose, S; Matsumoto, K; Saito, H; Murakami, T; Kobayashi, E,期刊:Stem Cells, 页码:878-887 , 文章类型: Article,,卷期:2009年27-4]
- Osteoarthritis in the knees, which can be caused by meniscal defect, constitutes an increasingly common medical problem. Repair for massive meniscal defect remains a challenge owing to a lack of cell kinetics for the men...
- Unexpected Multipotency of Melanoblasts Isolated from Murine Skin
[作者:Motohashi, T; Yamanaka, K; Chiba, K; Aoki, H; Kunisada, T,期刊:Stem Cells, 页码:888-897 , 文章类型: Article,,卷期:2009年27-4]
- Melanoblasts, precursor of melanocytes, are generated from the neural crest and differentiate into melanocytes during their migration throughout the entire body. The melanoblasts are thought to be progenitor cells that d...
- Characterization of DLK1(+) Cells Emerging During Skeletal Muscle Remodeling in Response to Myositis, Myopathies, and Acute Injury
[作者:Andersen, DC; Petersson, SJ; Jorgensen, LH; Bollen, P; Jensen, PB; Teisner, B; Schroeder, HD; Jensen, CH,期刊:Stem Cells, 页码:898-908 , 文章类型: Article,,卷期:2009年27-4]
- Delta like 1 (DLK1) has been proposed to act as a regulator of cell fate determination and is linked to the development of various tissues including skeletal muscle. Herein we further investigated DLK1 expression during ...
|