- Tunable synthetic phenotypic diversification on Waddington's landscape through autonomous signaling
[作者:Sekine, R; Yamamura, M; Ayukawa, S; Ishimatsu, K; Akama, S; Takinoue, M; Hagiya, M; Kiga, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17969-17973 , 文章类型: Article,,卷期:2011年108-44]
- Phenotypic diversification of cells is crucial for developmental and regenerative processes in multicellular organisms. The diversification concept is described as the motion of marbles rolling down Waddington's landscap...
- Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin
[作者:Grison, A; Mantovani, F; Comel, A; Agostoni, E; Gustincich, S; Persichetti, F; Del Sal, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17979-17984 , 文章类型: Article,,卷期:2011年108-44]
- Huntington disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the gene coding for huntingtin protein. Several mechanisms have been proposed by which mutant huntingtin (mHtt) may trigger stri...
- Myosin II isoform switching mediates invasiveness after TGF-beta-induced epithelial-mesenchymal transition
[作者:Beach, JR; Hussey, GS; Miller, TE; Chaudhury, A; Patel, P; Monslow, J; Zheng, Q; Keri, RA; Reizes, O; Bresnick, AR; Howe, PH; Egelhoff, TT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17991-17996 , 文章类型: Article,,卷期:2011年108-44]
- Despite functional significance of nonmuscle myosin II in cell migration and invasion, its role in epithelial-mesenchymal transition (EMT) or TGF-beta signaling is unknown. Analysis of normal mammary gland expression rev...
- Homogenization patterns of the world's freshwater fish faunas
[作者:Villeger, S; Blanchet, S; Beauchard, O; Oberdorff, T; Brosse, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18003-18008 , 文章类型: Article,,卷期:2011年108-44]
- The world is currently undergoing an unprecedented decline in biodiversity, which is mainly attributable to human activities. For instance, nonnative species introduction, combined with the extirpation of native species,...
- Genetically distinct coelacanth population off the northern Tanzanian coast
[作者:Nikaido, M; Sasaki, T; Emerson, JJ; Aibara, M; Mzighani, SI; Budeba, YL; Ngatunga, BP; Iwata, M; Abe, Y; Lie, WH; Okada, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18009-18013 , 文章类型: Article,,卷期:2011年108-44]
- Since the sensational discovery of a living coelacanth off the east coast of South Africa, the geographic distribution of viable coelacanth populations has been a subject of debate. In the past, the coelacanths off the A...
- Capsular polysaccharide vaccine for Group B Neisseria meningitidis, Escherichia coli K1, and Pasteurella haemolytica A2
[作者:Robbins, JB; Schneerson, R; Xie, GL; Ake-Hanson, L; Miller, MA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17871-17875 , 文章类型: Article,,卷期:2011年108-44]
- We reviewed the literature that is the basis for our proposal that (2 -> 8)-alpha-Neu5Ac conjugates will be safe and effective vaccines for Group B meningococci (GBMs), Escherichia coli K1, and Pasteurella haemolytica A2...
- Physical limits of cells and proteomes
[作者:Dill, KA; Ghosh, K; Schmit, JD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17876-17882 , 文章类型: Article,,卷期:2011年108-44]
- What are the physical limits to cell behavior? Often, the physical limitations can be dominated by the proteome, the cell's complement of proteins. We combine known protein sizes, stabilities, and rates of folding and di...
- Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase
[作者:Snyder, PW; Mecinovic, J; Moustakas, DT; Thomas, SW; Harder, M; Mack, ET; Lockett, MR; Heroux, A; Sherman, W; Whitesides, GM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17889-17894 , 文章类型: Article,,卷期:2011年108-44]
- The hydrophobic effect-a rationalization of the insolubility of nonpolar molecules in water-is centrally important to biomolecular recognition. Despite extensive research devoted to the hydrophobic effect, its molecular ...
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